Abec is a synthetic carbocyclic nucleoside associated with inhibitory activity against HIVand contains ingredients like Abacavir Abec is contains for the treatment of HIV-type I infection, it is used with other anti-retroviral medicines to control the infections. It is active against HIV viruses which effectively prevent it from progressing to AIDS. Abec is a prescription drug used under the guidance of medical practioners.
Abec tablet in concomitant use with other antiretroviral agentsare indicated for the treatment of HIV type I infection patients.
Mechanism of action
Abacavir which belongs to carbocyclic synthetic nucleoside analogue. Abacavir is changed by cellular enzymes to the active metabolite, carbovir triphosphate (CBV-TP), an analogue of deoxyguanosine-5′-triphosphate (dGTP). CBV-TP prohibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its fused into viral DNA.
Abec after oral administration, abacavir and is highly absorbed and its bioavailability occurs at 83% respectively
Abacavir has human plasma protein bounding nearly 50%
Abacavir metabolized by alcohol dehydrogenase and glucuronyl transferase.
The abacavir half-life of is 1.54±0.63 hours
Abec dosage and administration
The prescribed dose of Abec tablet is one tablet of Abacavir 600mg for adult to be taken orally as a single dose, either 300mg twice Daily or 600mg once daily in combination with other anti-retroviral medicines with or without food. In pediatric dose: depends on body weight dosage is calculated The patients weights of
- 14 to < 20 administer 1 tablet of 300mg given as morning half tablet 150mg and evening half tablet 150mg
- ≥ 20 to < 25 administered one and half tablets given as morning half tablet of 150mg and evening 1 tablet of 300mg
- ≥ 25 administer 2 tablets of 600mg given as morning 1 tablet of 300mg and evening 1 tablet of 300mg
Some common side effects
Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety
Serious side effects
Fatal hypersensitivity reactions Lactic acidosis and severe hepatomegaly with steatosis Exacerbations of hepatitis B Hepatic decompensated in patients co-infected with HIV-I and hepatitis C Immune reconstitution syndrome Fat redistribution Myocardial infraction
Caution with if patients having:
Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B Fat redistribution, myocardial infarction, hepatic impairment