Abamune

Abamune is a synthetic carbocyclic nucleoside associated with inhibitory activity against HIVand contains ingredients like Abacavir Abamune is contains for the treatment of HIV-type I infection, it is used with other anti-retroviral medicines to control the infections. It is active against HIV viruses which effectively prevent it from progressing to AIDS. Abamune is a prescription drug used under the guidance of medical practioners.

Abacavir

Abamune

300mg

Cipla





Abamune indication

Abamune tablet in concomitant use with other antiretroviral agentsare indicated for the treatment of HIV type I infection patients.

Mechanism of action

Abacavir which belongs to carbocyclic synthetic nucleoside analogue. Abacavir is changed by cellular enzymes to the active metabolite, carbovir triphosphate (CBV-TP), an analogue of deoxyguanosine-5′-triphosphate (dGTP). CBV-TP prohibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its fused into viral DNA.




PHARMACOKINETIC

Abamune after oral administration, abacavir and is highly absorbed and its bioavailability occurs at 83% respectively

Abacavir has human plasma protein bounding nearly 50%

Abacavir metabolized by alcohol dehydrogenase and glucuronyl transferase.

The abacavir half-life of is 1.54±0.63 hours



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Abamune
Brand Abamune
Ingredients Abacavir
Strength 300mg
Manufactured Cipla
Rating


Abamune dosage and administration

The prescribed dose of Abamune tablet is one tablet of Abacavir 600mg for adult to be taken orally as a single dose, either 300mg twice Daily or 600mg once daily in combination with other anti-retroviral medicines with or without food. In pediatric dose: depends on body weight dosage is calculated The patients weights of

  • 14 to < 20 administer 1 tablet of 300mg given as morning half tablet 150mg and evening half tablet 150mg
  • ≥ 20 to < 25 administered one and half tablets given as morning half tablet of 150mg and evening 1 tablet of 300mg
  • ≥ 25 administer 2 tablets of 600mg given as morning 1 tablet of 300mg and evening 1 tablet of 300mg

Some common side effects

Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety

Serious side effects

Fatal hypersensitivity reactions Lactic acidosis and severe hepatomegaly with steatosis Exacerbations of hepatitis B Hepatic decompensated in patients co-infected with HIV-I and hepatitis C Immune reconstitution syndrome Fat redistribution Myocardial infraction

Abamune precautions

Caution with if patients having:
Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B Fat redistribution, myocardial infarction, hepatic impairment

Abamune drug interaction

  • Zalcitabine, it is not concomitant with Abamune because the effect of lamivudine which is present in the drug and Zalcitabine are inhibits each other.
  • HLA-B*5701 allele not co administered with abacavir due to anaphylactic reactions occurs
  • If taking getting methadone maintenance therapy, with abacavir 600mg twice daily leads to increase the methadone clearance
  • Ethanol blocks the ability of the kidney to eliminate the drug abacavir



Abamune contraindications

Abamune tablets are contraindicated in the patients having Hypersensitivity reaction to components present in the product Severe hepatic impairment



Pregnancy category C: Abamune will affect serious harm to the unborn babies The use of Abamune in pregnant women may use with caution

Breastfeeding mothers should not take Abamune , it excreted in human milk Nursing mothers not give milk to the babies; it might have chance of postnatal transmission.

The storage condition at 20°C to 25°C keep it in dry place Protect away from moisture, heat, and light.

If patient missed a dose, then take the tablet immediately. The particular missed dose should be skipped and continue the next dose schedule. Do not take extra dose Consult with doctor about missed dose

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