ALECENSA 150mg is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).



240 capsules


Alecensa 150mg belongs to second generation oral drug which selectively prohibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is part used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Prohibitions of ALK prevents phosphorylation and following downstream activation of STAT3 and AKT resulting in reduced tumour cell viability.

Mechanism of action

Alectinib belongs tyrosine kinase inhibitor whichaims ALK and RET. In nonclinical studies, Alectinibprohibits ALK phosphorylation and ALK-mediated activation of the downstream signalling proteins STAT3 and AKT, and reduced tumor cell viability in multiple cell lines harbouring ALK fusions, amplifications, or activating mutations.


Peak plasma concentration 4 hours and bioavailability of Alecensa 37%

Alectinib bound to human plasma proteins 99%

Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.

In oral administration, radioactivity 98% was excreted in feces. 84% dose was excreted in the feces unchanged Alectinib.
Half-life is 33 hours


Ingredients Alectinib
Strength 150mg
Pack 240 capsules

Non- Small Cell Lung Cancer :
The recommended dose is 600mg PO BID until disease progression or unacceptable Renal impairment patients dose is 450mg orally twice daily Alecensa is administrated with food

Side effects

• Muscle pain
• Bradycardia
• Tiredness
• Constipation
• Anemia
• Hepatotoxicity
• Feeling tired
• Feeling less hungry than usual
• Dark urine
• Itchy skin
• Nausea or vomiting
• Abdominal Pain on the right side
• Bleeding or bruising more easily than normal.
Lung Problems:
• Trouble breathing
• Shortness of breath
• Cough
• Fever


Due to Alecensa administration, Symptomatic bradycardia may have observed; control heart rate and blood pressure regularly
Alecensa may causes Severe myalgia and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;
Embryo-fetal toxicity: Based on data from animal studies and its mechanism of action, Alecensa can cause fetal harm when administered to pregnant women.
Renal impairment occurred during Alecensa treatment; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.


  • No pharmacokinetic interactions with Alecensa 150mg needed dosage adjustment have been observed.



Based on studies of animal and mechanism of action, Alecensa 150mg will cause fetal harm when given to pregnant women Advice the female not to become pregnant while on treatment with Alecensa

During treatment with Alecensa, advise the women not to breastfed to infants

Store at below 25°C Store the drug in original container

If the patient vomits after taking a dose of ALECENSA or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.

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