APALUTAMIDE 60MG

Erleada is indicated for the treatment in patients having nonmetastatic castration-resistant prostate cancer (NM-CRPC)

Apalutamide

60mg

120 tablets




Description

Apalutamide is a generic form of brand name Erleada 60mg and it is a prescription medicine used under the guidance of medical practioners.
Erleada 60mg is required to treat prostate cancer which has not spread to other parts of the body and no longer responds to a medical or surgical treatment whichreduces testosterone.
It is unknown if ERLEADA is safe or persuasive in children.

Mechanism of action

Apalutamide is anAndrogen receptor (AR) inhibitor whichlinked directly to the ligand-binding domain of the AR andprevents AR nuclear translocation along with inhibits DNA binding, and hinder AR-mediated transcription Administration caused reduced tumor cell replication and have higher apoptosis, leading to lowered tumor volume in mouse xenograft models of prostate cancer.



Pharmacokinetic

Duration to peak plasma concentration is 2hr and peak plasma concentration is 6mcg/mL and 5.9mcg/mL and steady-state achieved is 4 weeks

Human plasma protein binding of Apalutamide is 96% and N-desmethyl Apalutamide

Primarily the drug metabolized by CYP2C8 for the formation of N-desmethyl Apalutamide

Apalutamide excreted via urine 65% and feces 24% Half-life is 3 days.



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apalutamide-60mg

Ingredients Apalutamide
Strength 60mg
Pack 120 tablets
Rating

Erleada recommended dose for adult is 240mg administrated four tablets containing 60mg given orally once daily.
The whole tablet should be swallow
Erleada tablet can be consume with or without food
Along with Apalutamide the patients should also receive a gonadotropin-releasing hormone(GnRH) associated concurrently or should have had a bilateral orchiectomy
While patients have ≥ grade 3 toxicity or intolerable side effect then dosage modification should have needed
Wait dosing until symptoms improve to ≤Grade 1 or original grade, after that proceed at the same dose or a decreased dose (180 mg or 120 mg), if warranted

Side effects

Erleada has caused some side effect but most people will not affect all the side effect listed :
The drugs Common side effects which occurring in greater than 30% are;
Fatigue, Low RBC and WBC, Cholesterol and triglycerides increased, Blood sugar level increased, Potassium levels increased, Less common side effects occurring in 10-29%, Increased blood pressure, Diarrhea, Nausea, Peripheral edema , Hot flashes, Skin rash, Dizziness/falling, Thyroid dysfunction , Muscle weakness, Joint pain, Lack of appetite, Falls, Fractures, Weight loss.

Precautions

While using Erleada 60mg tablets will causes falls and fractures, patients should evaluate for risk and monitor and manage patients at risk for fractures along with established treatment guidelines.
Erleada 60mg may causes seizures then permanently discontinue if seizure occurs during treatment. Hence advise patients about developing risk due to seizure, it may lead to sudden loss of memory while engaging in activities.

DRUG – DRUG INTERACTION

  • Erleada concomitant use with strong CYP2C8 or CYP3A4 inhibitor is determined to have high the steady state exposure of the active molecule.
  • Erleada concomitant use with primarily metabolized by CYP3A4, CYP2C19 or CYP2C9 can reported in reduce exposure to these medications

Contraindications

Erleada is contraindicated in pregnant women because it will lead risk to fetal and probably loss of pregnancy




The drug is not indicated for females and there is no data regarding using during pregnancy, based on its pharmacological action, Erleada will cause harm to fetal and probably loss of pregnancy

Erleada is not indicated for female patients

Store the drug at 20°C to 25°C.
Store in the original container.
Protect from light and moisture.

If dose is missed, then take the dose as soon as possible before reach of next dose time or skip the missed dose and follow the normal schedule. Do not have extra dose which leads to over dosage Consult the doctor about missed dose and overdose


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