Erleada is indicated for the treatment in patients having nonmetastatic castration-resistant prostate cancer (NM-CRPC)
Apalutamide is a generic form of brand name Erleada 60mg and it is a prescription medicine used under the guidance of medical practioners.
Erleada 60mg is required to treat prostate cancer which has not spread to other parts of the body and no longer responds to a medical or surgical treatment whichreduces testosterone.
It is unknown if ERLEADA is safe or persuasive in children.
Mechanism of action
Apalutamide is anAndrogen receptor (AR) inhibitor whichlinked directly to the ligand-binding domain of the AR andprevents AR nuclear translocation along with inhibits DNA binding, and hinder AR-mediated transcription
Administration caused reduced tumor cell replication and have higher apoptosis, leading to lowered tumor volume in mouse xenograft models of prostate cancer.
Duration to peak plasma concentration is 2hr and peak plasma concentration is 6mcg/mL and 5.9mcg/mL and steady-state achieved is 4 weeks
Human plasma protein binding of Apalutamide is 96% and N-desmethyl Apalutamide
Primarily the drug metabolized by CYP2C8 for the formation of N-desmethyl Apalutamide
Apalutamide excreted via urine 65% and feces 24% Half-life is 3 days.
Erleada recommended dose for adult is 240mg administrated four tablets containing 60mg given orally once daily.
The whole tablet should be swallow
Erleada tablet can be consume with or without food
Along with Apalutamide the patients should also receive a gonadotropin-releasing hormone(GnRH) associated concurrently or should have had a bilateral orchiectomy
While patients have ≥ grade 3 toxicity or intolerable side effect then dosage modification should have needed
Wait dosing until symptoms improve to ≤Grade 1 or original grade, after that proceed at the same dose or a decreased dose (180 mg or 120 mg), if warranted
Erleada has caused some side effect but most people will not affect all the side effect listed :
The drugs Common side effects which occurring in greater than 30% are;
Fatigue, Low RBC and WBC, Cholesterol and triglycerides increased, Blood sugar level increased, Potassium levels increased, Less common side effects occurring in 10-29%, Increased blood pressure, Diarrhea, Nausea, Peripheral edema , Hot flashes, Skin rash, Dizziness/falling, Thyroid dysfunction , Muscle weakness, Joint pain, Lack of appetite, Falls, Fractures, Weight loss.
While using Erleada 60mg tablets will causes falls and fractures, patients should evaluate for risk and monitor and manage patients at risk for fractures along with established treatment guidelines.
Erleada 60mg may causes seizures then permanently discontinue if seizure occurs during treatment. Hence advise patients about developing risk due to seizure, it may lead to sudden loss of memory while engaging in activities.