Atavir contains a prime ingredient known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir exhibiting by prohibits the protease enzyme activity. Itworks by reducing the amount of HIV virus in blood by interfering with maturation of cells. Atavir is not taken alone; it may combine with other anti-retroviral medicines like Ritonavir.
Atavir (Atazanavir), an anti-retroviral medication used to treat HIV type I infection.
Atavir helps to reduce the amount of HIV virus in blood.
It reduces the chance of getting AIDS
Mechanism of action
Atavir is a protease inhibitor, this enzyme involved in cleavage of viral polyprotein
Atavir is effective against HIV type I infection, it inhibits the cleavage of Gag-Pol polyprotein.
This inhibition occurs by Atazanavir active form of Atavir , bounds to protease enzyme and stops the action produced by that particular enzyme So, the inhibition of cleavage leads to formation of immature cells.
The peak plasma concentration of the drug Atazanavir is occurred within 2.5 hours
Atavir (atazanavir) is highly bound to human plasma protein at nearly 86% If Atavir taken with food, it may increase the bioavailability and reduce pharmacokinetic variability
Atavir is largely metabolized in liver. The two major biotransformation pathways in Atavir is; Mono-oxygenation Di-oxygenation
The elimination occurs through feces and urine. The terminal half-life of the drug in infected patients is approximately 6 hours.
Atavir is combined with other anti-retroviral medicine like, Ritonavir The recommended dose is 300mg should be taken orally as a single dose with 100mg ritonavir If patient is not able to tolerate Ritonavir, 400mg of Atavir should be taken once a day with food Atavir combined with efavirenz: 400mg PO with 100mg ritonavir qDay
Recommended dose: 300mg orally as a single dose Combination with H2 receptor antagonist and tenofovir: 400mg PO with 100mg ritonavir qDay
Mild: 400mg PO qDay Moderate: 300mg PO qDay Severe: not recommended
Final stage of renal disease hemodialysis: 300mg PO with 100mg ritonavir qDay
6-18 years (treatment naïve and treatment experienced)
<15kg: Atavir is not recommended
15kg to <35kg: 200mg PO with 100mg ritonavir qDay
≥35kg: 300mg PO with 100mg ritonavir qDay
≥13 years (patient non-tolerated to ritonavir)
≥40kg: 400mg PO qDay
Atavir Side effects
>10%: Total bilirubin level elevated, Fever, Rash, Increased cholesterol, Nausea, CPK increased, Cough, Diarrhea, Neutrophils counts depleted, Jaundice, Headache, Peripheral neuropathy, Insomnia, Myalgia, Abdominal pain, Depression, Dizziness, Vomiting, Prolonged PR interval, Diabetes mellitus, Edema, QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia
Atavir should not use with proton pump inhibitor in treatment experienced patients Tablet Atavir should be discontinue if patient getting severe rash or other anaphylactic reactions Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels