Atavir contains a prime ingredient known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir exhibiting by prohibits the protease enzyme activity. Itworks by reducing the amount of HIV virus in blood by interfering with maturation of cells. Atavir is not taken alone; it may combine with other anti-retroviral medicines like Ritonavir.





Atavir Indication

Atavir (Atazanavir), an anti-retroviral medication used to treat HIV type I infection.

Atavir helps to reduce the amount of HIV virus in blood.

It reduces the chance of getting AIDS

Mechanism of action

Atavir is a protease inhibitor, this enzyme involved in cleavage of viral polyprotein Atavir is effective against HIV type I infection, it inhibits the cleavage of Gag-Pol polyprotein.

This inhibition occurs by Atazanavir active form of Atavir , bounds to protease enzyme and stops the action produced by that particular enzyme So, the inhibition of cleavage leads to formation of immature cells.


The peak plasma concentration of the drug Atazanavir is occurred within 2.5 hours

Atavir (atazanavir) is highly bound to human plasma protein at nearly 86% If Atavir taken with food, it may increase the bioavailability and reduce pharmacokinetic variability

Atavir is largely metabolized in liver. The two major biotransformation pathways in Atavir is; Mono-oxygenation Di-oxygenation

The elimination occurs through feces and urine. The terminal half-life of the drug in infected patients is approximately 6 hours.

Brand Atavir
Ingredients Atazanavir
Strength 300mg
Manufactured Cipla

In adults

HIV-1 infection

Treatment naive

Atavir is combined with other anti-retroviral medicine like, Ritonavir The recommended dose is 300mg should be taken orally as a single dose with 100mg ritonavir If patient is not able to tolerate Ritonavir, 400mg of Atavir should be taken once a day with food Atavir combined with efavirenz: 400mg PO with 100mg ritonavir qDay

Treatment experienced

Recommended dose: 300mg orally as a single dose Combination with H2 receptor antagonist and tenofovir: 400mg PO with 100mg ritonavir qDay

Hepatic impairment

Mild: 400mg PO qDay Moderate: 300mg PO qDay Severe: not recommended

Renal impairment

Final stage of renal disease hemodialysis: 300mg PO with 100mg ritonavir qDay

In pediatric

6-18 years (treatment naïve and treatment experienced)
<15kg: Atavir is not recommended
15kg to <35kg: 200mg PO with 100mg ritonavir qDay
≥35kg: 300mg PO with 100mg ritonavir qDay
≥13 years (patient non-tolerated to ritonavir)
≥40kg: 400mg PO qDay

Atavir Side effects

>10%: Total bilirubin level elevated, Fever, Rash, Increased cholesterol, Nausea, CPK increased, Cough, Diarrhea, Neutrophils counts depleted, Jaundice, Headache, Peripheral neuropathy, Insomnia, Myalgia, Abdominal pain, Depression, Dizziness, Vomiting, Prolonged PR interval, Diabetes mellitus, Edema, QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia

Atavir Precautions

Atavir should not use with proton pump inhibitor in treatment experienced patients Tablet Atavir should be discontinue if patient getting severe rash or other anaphylactic reactions Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels

Atavir Drug interaction

Some list of medicines get interacts with Atavir ; Alfuzosin, astemizole, carbamazepine, Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, lovastatin, pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc

Atavir Contraindication

Patients are contraindicated to the ingredients present in the Atavir tablet Anaphylactic reaction occurs Atavir is contraindicated in the conditions; Chronic hepatitis B, C Diabetes, Lactic acidosis, Hemophilia, Gallstones, Kidney impairment, High amount of bilirubin

Pregnancy category: B Treatment experienced pregnant women during II or III trimester: co administration of Atavir with H2 receptor antagonist or tenofovir, a dose of 400mg with 100mg ritonavir as a single use
Maternal adverse effects:
Lactic acidosis, symptomatic hyperlactatemia, Hyperbilirubinemia
Fetal/Neonatal adverse effects:
Severe Hyperbilirubinemia Not breastfeed to infants to prevent transmission of HIV-1 infection

Atavir should be stored at room temperature, 68°F to 77°F (20°C to 25°C). keep away the container from moisture, heat and light.

Atavir tablet is a prescription medicine; if patient fail to administer the dose, advise them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule

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