Atazor R

Atazor R belongs to anti-viral medication which is includes atazanavir & ritonavir as an active moiety. Ritonavir is also a protease enzyme inhibitor, which is a peptidomimetic agent for both HIV-1 & HIV-2 type infections. Atazor R tablets are fixed dose combination, which is categorized as protease inhibitor. Atazanavir is a chemically classified as azapeptide, which is containing bis-aryl substituent on hydrazine moiety exhibits anti-retroviral activity against wild type & mutant forms of HIV protease.

Atazanavir & Ritonavir

Atazor R

300mg & 100mg

Emcure






Atazor R indication

Atazor R tablet includes active molecules are classified as protease inhibitor, which is contain in the treatment of HIV-1 infections.

Mechanism of Atazor R

Ritonavir:
HIV protease enzymes which is includes in division of auxiliary and multiplicative proteins that may deliver from significant HIV qualities, similar to choke and pol. This action of protein ought to be diminished because of repressing the protease chemical by ritonavir, a functioning substance of Ritomune tablets. Gal: cover the proteins confused in center and nucleocapsid. Pol: cover the turnaround transcriptase, ribonuclease H, integrase and protease. The division of lady buddy polyprotein ought to be counteracted by ritonavir which prompts generation of youthful and non-irresistible viral particles.

Atazanavir:
Atazanavir specifically restrains the infection particular preparing of viral Gag and Gag-Pol polyproteins in HIV-1 contaminated cells by official to the dynamic site of HIV-1 protease, hence keeping the arrangement of develop virions. Atazanavir isn't dynamic against HIV-2.



Pharmacokinetic

Atazanavir is administering with food will leads to increase the bioavailability and decreases the pharmacokinetics variability.The mean oral bioavailability of atazanavir is 60 to 68%. The absorption of atazanavir is occurs very quickly; with Tmax value is 2.5 hours. After administration of ritonavir, the maximum plasma concentration is reaches within 2 hours & 4 hours in both fasted & non fasted condition.

Ritonavir is highly binds to human plasma protein by 98 to 99%. Atazanavir is binds to serum proteins by 86%.

Ritonavir has major metabolite such as Isopropylthiazole oxidation. The major isoenzyme used for the metabolism of ritonavir is CYP3A. Atazanavir is highly metabolized, in liver. The biotransformation of atazanavir majorly occurs by undergoing Monooxygenation & Dioxygenation.

The elimination process of ritonavir is majorly via feces & urine. The mean terminal half life period of ritonavir is 3 to 5 hours. The mean terminal half life period of atazanavir is relatively 7 hours.




Blueberrypharma.com-img1

Atazor R
Brand Atazor R
Ingredients Atazanavir & Ritonavir
Strength 300mg & 100mg
Manufactured Emcure
Rating

Dosage and administration of Atazor R

Atazanavir should not used alone; it should be combined with ritonavir which is majorly prescribed for therapy experienced adult patients with preceding virologic failure. The higher dose of ritonavir will cause reducing the safety profile of atazanavir.

Before starting the treatment with atazanavir

Patients who are going to receiving the atazanavir should be performed with renal function test periodically for both prior and during the therapy. Serum creatinine, creatinine clearance, urine analysis should be checked frequently. Hepatic function test is also performed before starting & during the treatment.

In adults

The prescribed dose of Atazor R is one tablet should be administered as a single dose by combining with any of the following drugs like;Tenofovir, H2 receptor antagonist: Proton pump inhibitors

In therapy experienced patients (adults)

The recommended dose is one tablet of Atazor R should be administered as a single dose.

Combination therapy

H2 receptor antagonist: The gastric regulator drug should not be exceeding a dose equal to famotidine 20mg as two times a day. Atazor R tablets should be concurrently administered with & or at least 10 hours after the dose of H2 receptor antagonist. If patient taking H2 receptor antagonist, Atazor R tablets should be taken with food. If patients administered tenofovir & H2 receptor antagonist concurrently, then Atazor R tablets should not be recommend. In therapy experienced patients who are getting Atazor R tablets, proton pump inhibitor should not be recommended. Atazor R tablets should not be administered with efavirenz, because of reducing atazanavir exposure.

In pregnant women

The recommended dose of Atazor R is; In both new commenced or already treated patients: The prescribed dose is one Atazor R tablet should be administered as a single dose. In case of combination of H2RA or tenofovir DF, the recommended dose is 400mg of atazanavir & 100mg of ritonavir should be recommended as a single dose. In therapy experienced pregnant patients during 2nd or 3rd trimester, atazanavir should not be suggested. In severe condition, Atazor R tablets should not be used. Atazor R tablets should be administered with food. Atazor R tablets are fixed dose combination; it should not be breaking, chew or crush.

The major adverse effects of Atazor R tablets are

Cardiac conduction abnormalities Rash Increased bilirubin levels Chronic kidney disease Nephrolithiasis Cholelithiasis

The common side effects

Increased AST, ALT, Increased lipase, Increased creatine kinase, Neutropenia, Increased glucose, Increased triglycerides, Decreased platelets

Post marketing reports

Edema, Pancreatitis, Liver function abnormalities, Diabetes mellitus, Arthralgia, Alopecia, Maculopapular rash, Angioedema, Pruritus

Some adverse effects may occur during therapy using with Atazor R tablets

Cardiac conduction abnormalities
This is due to prolonged elevation of PR intervals by atazanavir. Monitor with ECG frequently for reducing the adverse effects.

Kidney disease
During the Atazor R treatment patient should be monitored with renal function test.

Nephrolithiasis & cholelithiasis
To overcome the problem, patient must be provided with additional management. Temporary postponement or discontinuation of therapy is occurring. Adverse effects may occur due to drug interactions, like; Atazor R with drugs are metabolized by CYP3A or CYP3A causes increased concentration of these drugs.

Skin reactions
Rash is the one of the most important effect occurred on skin. Atazanavir should be stopped during rashes present.

Hemophilia
Severe bleeding occurs, discontinue the protease inhibitor therapy.

Increased bilirubin
Symptomatic elevation of bilirubin occurs by prohibits the UDP glucuronosyl transferase. Dose reduction is not possible, once the level of bilirubin is elevates stop the treatment.

Diabetes mellitus
Check the blood glucose level periodically Patient must be prescribed with dose adjustment insulin or oral hypoglycemic agents. Diabetes ketoacidosis should be occurred after discontinue the treatment.

Immune reconstitution syndrome
Stop the Atazor R therapy. Redistribution of fat occurred in the body leads to cause obesity. To overcome the problem in severe condition, discontinue the treatment.

Drug- drug interaction

  • Co administration of Atazor R tablets with drugs formerly metabolized by CYP3A or UGT1A1, results as elevation of plasma concentration of these drugs because atazanavir is an inhibitor of CYP3A & UGT1A1.
  • Atazor R administered with substrate of CYP2C8, interaction is not identified. Atazanavir is a weak inhibitor of CYP2C8.
  • Atazor R with CYP3A4 inducers causes decreasing the plasma concentration of atazanavir and leads to loss of effect of atazanavir.
  • The solubility of atazanavir is depends on pH levels, if co administration of Atazor R with gastric regulator drugs leads to cause decreased plasma concentration of atazanavir. Atazor R with Didanosine buffered tablets, causes decreasing the effect of concentration of atazanavir.
  • Atazor R tablets with Didanosine EC results as decrease in concentration of Didanosine. Tenofovir DF leads to alter the AUC & Cmin value of atazanavir, in adults the recommended odse of 300mg atazanavir, with 100mg of ritonavir should be given with tenofovir DF 300mg ledas to cause increasing concentration of tenofovir.
  • Atazor R tablet should not be combined with efavirenz, leads to decrease the concentration of atazanavir.
  • Atazor R with boceprevir, this combination causes reducing the effect of concentration of component in Atazor R.
  • Gastric regulator drugs should not be simultaneously administered with Atazor R tablets.

contraindications


Atazor R should be contraindicated for:
Patients suffered with hypersensitivity reaction, because patients are contraindicated to the component present in the Atazor R . Atazor R is contraindicated to strong CYP3A inducers; it may causes loss of effectiveness of atazanavir.

Some drugs are contraindicated to Atazor R like:
Rifampin: decreases the concentration of atazanavir Irinotecan: atazanavir inhibits the UGT1A1, which is responsible for metabolism of Irinotecan.



Pregnancy category: B Atazanavir should be used in limited number of pregnant women. Atazor R tablets should be used with caution only after knowing the risk factor associated with the treatment. Breast feeding should not be allowed while the patient undergoing HIV-1 infection therapy.

Atazor R tablet container should be kept in cool & dry place.

Missed dose of Atazor R should be avoided. In case of missed dose, patient must be consult with physician and follow the instructions. Maintain the regular dosing schedule.

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.