Atazor contains a prime ingredient known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir exhibiting by prohibits the protease enzyme activity. Itworks by reducing the amount of HIV virus in blood by interfering with maturation of cells. Atazor is not taken alone; it may combine with other anti-retroviral medicines like Ritonavir.





Atazor Indication

Atazor (Atazanavir), an anti-retroviral medication used to treat HIV type I infection.

Atazor helps to reduce the amount of HIV virus in blood.

It reduces the chance of getting AIDS

Mechanism of action

Atazor is a protease inhibitor, this enzyme involved in cleavage of viral polyprotein Atazor is effective against HIV type I infection, it inhibits the cleavage of Gag-Pol polyprotein.

This inhibition occurs by Atazanavir active form of Atazor , bounds to protease enzyme and stops the action produced by that particular enzyme So, the inhibition of cleavage leads to formation of immature cells.


The peak plasma concentration of the drug Atazanavir is occurred within 2.5 hours

Atazor (atazanavir) is highly bound to human plasma protein at nearly 86% If Atazor taken with food, it may increase the bioavailability and reduce pharmacokinetic variability

Atazor is largely metabolized in liver. The two major biotransformation pathways in Atazor is; Mono-oxygenation Di-oxygenation

The elimination occurs through feces and urine. The terminal half-life of the drug in infected patients is approximately 6 hours.

Brand Atazor
Ingredients Atazanavir
Strength 300mg
Manufactured Emcure

In adults

HIV-1 infection

Treatment naive

Atazor is combined with other anti-retroviral medicine like, Ritonavir The recommended dose is 300mg should be taken orally as a single dose with 100mg ritonavir If patient is not able to tolerate Ritonavir, 400mg of Atazor should be taken once a day with food Atazor combined with efavirenz: 400mg PO with 100mg ritonavir qDay

Treatment experienced

Recommended dose: 300mg orally as a single dose Combination with H2 receptor antagonist and tenofovir: 400mg PO with 100mg ritonavir qDay

Hepatic impairment

Mild: 400mg PO qDay Moderate: 300mg PO qDay Severe: not recommended

Renal impairment

Final stage of renal disease hemodialysis: 300mg PO with 100mg ritonavir qDay

In pediatric

6-18 years (treatment naïve and treatment experienced)
<15kg: Atazor is not recommended
15kg to <35kg: 200mg PO with 100mg ritonavir qDay
≥35kg: 300mg PO with 100mg ritonavir qDay
≥13 years (patient non-tolerated to ritonavir)
≥40kg: 400mg PO qDay

Atazor Side effects

>10%: Total bilirubin level elevated, Fever, Rash, Increased cholesterol, Nausea, CPK increased, Cough, Diarrhea, Neutrophils counts depleted, Jaundice, Headache, Peripheral neuropathy, Insomnia, Myalgia, Abdominal pain, Depression, Dizziness, Vomiting, Prolonged PR interval, Diabetes mellitus, Edema, QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia

Atazor Precautions

Atazor should not use with proton pump inhibitor in treatment experienced patients Tablet Atazor should be discontinue if patient getting severe rash or other anaphylactic reactions Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels

Atazor Drug interaction

Some list of medicines get interacts with Atazor ; Alfuzosin, astemizole, carbamazepine, Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, lovastatin, pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc

Atazor Contraindication

Patients are contraindicated to the ingredients present in the Atazor tablet Anaphylactic reaction occurs Atazor is contraindicated in the conditions; Chronic hepatitis B, C Diabetes, Lactic acidosis, Hemophilia, Gallstones, Kidney impairment, High amount of bilirubin

Pregnancy category: B Treatment experienced pregnant women during II or III trimester: co administration of Atazor with H2 receptor antagonist or tenofovir, a dose of 400mg with 100mg ritonavir as a single use
Maternal adverse effects:
Lactic acidosis, symptomatic hyperlactatemia, Hyperbilirubinemia
Fetal/Neonatal adverse effects:
Severe Hyperbilirubinemia Not breastfeed to infants to prevent transmission of HIV-1 infection

Atazor should be stored at room temperature, 68°F to 77°F (20°C to 25°C). keep away the container from moisture, heat and light.

Atazor tablet is a prescription medicine; if patient fail to administer the dose, advise them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule

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