Azee 250mg is used to treat a wide variety of bacterial infections. It is a macrolide-type antibioticand which fights against bacteria and its belongs to the class of Azalide It works by stopping the growth of bacteria. This regimensdo not used for viral infections (such as common cold, flu). Unwanted use or misuse of any antibiotic can lead to its reduced effectiveness.
AZEE USED FOR
Azee 250mg tablets can be indicated for the treatment of the following infections, when caused by microorganisms sensitive to azithromycin - acute bacterial sinusitis (adequately diagnosed)
Acute bacterial otitis media (adequately diagnosed), pharyngitis, tonsillitis, acute exacerbation of chronic bronchitis (adequately diagnosed), mild to moderately severe community acquired pneumonia, skin and soft tissue infections, uncomplicated Chlamydia trachomatis urethritis and cervicitis
Mechanism of action
Azithromycin works by connecting to the 23S rRNA of the 50S ribosomal subunit of susceptible micro organisms preventing bacterial protein synthesis and impeding the assembly of the 50S ribosomal subunit.
Fastly absorbed from the GI tract. Decreased by food (capsule formulation). bioavailability: Approx 34-52%. Duration of high plasma concentration: Oral tab: 2-3 hr
Volume of distribution: 31-33 L/kg. Plasma protein binding (based on concentration): 7-51% (oral and IV).
Metabolism occur in Hepatic through demethylation.
Through bile (as unchanged drug and inactive metabolites); urine (approx 6% of oral dose). Terminal elimination half-life: 68 hr.
In effortless Chlamydia trachomatis urethritis and cervicitis, the dose is 1000 mg as a single oral dose.
For all other uses of the dose is 1500 mg, to be administered as 500 mg per day for three consecutive days. As andifferential of the same total dose (1500 mg) can also be administered over a period of five days with 500 mg on the first day and 250 mg on the second to the fifth day.
For pharyngitis or tonsillitis:
500mg on day 1 taken as single dose followed by 250mg on 2nd day through 5th day
In children for infections (6months age – older):
based on body weight is dose and must be determined by your doctor. 10 to 30mg/kg of body weight once daily, taken as a single dose. Based on the type of infection, continue with doses of 5 to 10 mg/kg of body weight once daily for several days. Infants < 6 months: discuss with doctor
For pharyngitis or tonsillitis: based on body weight:
12mg/kg of body weight once daily for 5 days. < 2yrs children’s: discuss with doctor for dose.
Method of administration
Azee Tablets should be given as a single daily dose. The tablets may be taken with food.
If dose administer higher than prescribed dose will cause nausea, diarrhea, vomiting. If it occurs, then provide general symptomatic and supportive measures are indicated as needed
Some serious side effects are caused by Azee 250mg
Watery or bloody diarrhea Pain in head associated with chest discomfort and severe vertigo, fainting, fast heartbeats Hepatic problems – upper stomach pain, decreased appetite, dark urine, clay-colored stools, jaundice Serious dermatological reaction – fever, pharyngitis, blisters in face or tongue, burning of eyes, red or purple skin rashes.
Common side effects of Azee 250mg as follows
Diarrhae, Nausea, vomiting, stomach pain, Pain in head. If these symptoms occur call doctor immediately
WARNING & PRECAUTIONS Of Azee
- While use of antibacterial agents will cause mild diarrhea to fatal colitis and it alters the normal colon flora results overgrowth of C.difficile. These will produce toxin A and Toxin B leads to development of CDAD and hence increases morbidity and mortality. Before using Azee 250mg inform the doctor.
- If an allergic reaction occurs including angioedema, anaphylaxis and dermatologic reactions, the drug should be discontinuing, and convenient treatment must have carried out. Consult with doctor for the symptoms arise.
- If symptoms of abnormal liver function, cholestatic jaundice, liver necrosis have occurred then stop the azithromycin and inform the doctor.