Azithral 250mg

Azithral 250mg is used to treat a wide variety of bacterial infections. It is a macrolide-type antibioticand which fights against bacteria and its belongs to the class of Azalide It works by stopping the growth of bacteria. This regimensdo not used for viral infections (such as common cold, flu). Unwanted use or misuse of any antibiotic can lead to its reduced effectiveness.

Azithromycin

Azithral

250mg

Alembic




Azithral USED FOR

Azithral 250mg tablets can be indicated for the treatment of the following infections, when caused by microorganisms sensitive to azithromycin - acute bacterial sinusitis (adequately diagnosed)

Acute bacterial otitis media (adequately diagnosed), pharyngitis, tonsillitis, acute exacerbation of chronic bronchitis (adequately diagnosed), mild to moderately severe community acquired pneumonia, skin and soft tissue infections, uncomplicated Chlamydia trachomatis urethritis and cervicitis

Mechanism of action

Azithromycin works by connecting to the 23S rRNA of the 50S ribosomal subunit of susceptible micro organisms preventing bacterial protein synthesis and impeding the assembly of the 50S ribosomal subunit.



Pharmacokinetics

Fastly absorbed from the GI tract. Decreased by food (capsule formulation). bioavailability: Approx 34-52%. Duration of high plasma concentration: Oral tab: 2-3 hr

Volume of distribution: 31-33 L/kg. Plasma protein binding (based on concentration): 7-51% (oral and IV).

Metabolism occur in Hepatic through demethylation.

Through bile (as unchanged drug and inactive metabolites); urine (approx 6% of oral dose). Terminal elimination half-life: 68 hr.


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Azithral 250mg
Brand Azithral
Ingredients Azithromycin
Strength 250mg
Manufactured Alembic
Rating

Adults

In effortless Chlamydia trachomatis urethritis and cervicitis, the dose is 1000 mg as a single oral dose. For all other uses of the dose is 1500 mg, to be administered as 500 mg per day for three consecutive days. As andifferential of the same total dose (1500 mg) can also be administered over a period of five days with 500 mg on the first day and 250 mg on the second to the fifth day.

For pharyngitis or tonsillitis:
500mg on day 1 taken as single dose followed by 250mg on 2nd day through 5th day

In children for infections (6months age – older):
based on body weight is dose and must be determined by your doctor. 10 to 30mg/kg of body weight once daily, taken as a single dose. Based on the type of infection, continue with doses of 5 to 10 mg/kg of body weight once daily for several days. Infants < 6 months: discuss with doctor

For pharyngitis or tonsillitis: based on body weight:
12mg/kg of body weight once daily for 5 days. < 2yrs children’s: discuss with doctor for dose.

Method of administration
Azithral Tablets should be given as a single daily dose. The tablets may be taken with food.

OVERDOSE

If dose administer higher than prescribed dose will cause nausea, diarrhea, vomiting. If it occurs, then provide general symptomatic and supportive measures are indicated as needed

Some serious side effects are caused by Azithral 250mg

Watery or bloody diarrhea Pain in head associated with chest discomfort and severe vertigo, fainting, fast heartbeats Hepatic problems – upper stomach pain, decreased appetite, dark urine, clay-colored stools, jaundice Serious dermatological reaction – fever, pharyngitis, blisters in face or tongue, burning of eyes, red or purple skin rashes.

Common side effects of Azithral 250mg as follows

Diarrhae, Nausea, vomiting, stomach pain, Pain in head. If these symptoms occur call doctor immediately

WARNING & PRECAUTIONS Of Azithral

  • While use of antibacterial agents will cause mild diarrhea to fatal colitis and it alters the normal colon flora results overgrowth of C.difficile. These will produce toxin A and Toxin B leads to development of CDAD and hence increases morbidity and mortality. Before using Azithral 250mg inform the doctor.
  • If an allergic reaction occurs including angioedema, anaphylaxis and dermatologic reactions, the drug should be discontinuing, and convenient treatment must have carried out. Consult with doctor for the symptoms arise.
  • If symptoms of abnormal liver function, cholestatic jaundice, liver necrosis have occurred then stop the azithromycin and inform the doctor.

DRUG INTERACTION OF Xtandi CAPSULE

  • Concomitant use of Azithral 250mg with Nelfinavir will increases azithromycin serum concentrations.

  • Interaction ofAzithral 250mg with Warfarin causes Prothrombin times should be carefully monitored while patients gettingcontinues azithromycin and oral anticoagulants
  • Azithral 250mg combination with Macrolides leads to Serum concentration of macrolides may increase when combined with Azithromycin

CONTRAINDICATIONS

The patients using Azithral 250mg is contraindicated with hypersensitivity to azithromycin and its components. Azithral 250mg using patients are contraindicated with history of liver discomfort analog to before use of azithromycin



Category B: there are no studies demonstrated for fetal risk in animal reproduction and no controlled studies have been shown in pregnant women or animal reproduction in 1st trimester and later trimester there is no evidence of a risk.

A small amount of drug is excreted in breast milk. Use with caution while using in breast feeding mother. Please consult the doctor for further details.

Stored below 30°C Keep away from the children Don’t store outdated medicine Discuss with pharmacist for the disposal of unused drugs

Take the missed dose immediately before next dose reaches or skip the missed dose and follows the routine schedule. Don’t make up with extra dose. Please consult with the doctor.

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