Bdenza capsules belongs to nonsteroidal antiandrogen drug which is indicated for use in conjunction with castration to treat metastatic castration-resistant prostate cancer (mCRPC). Bdenza capsule is in the form of liquid – filled soft gelatin capsules administer via oral route. Each capsule consists of 40mg enzalutamide in the form of solution in caprylocaproyl polyoxylglycerides.






Bdenza 40mg capsule is an anticancer medication which used for the treatment of patients with metastatic castration resistant prostate cancer.

(i.e. surgical treatments that lower testosterone/ prostate cancer that is resistant to medical).


Prostate cells are normally called as androgen receptors. Androgens join with these receptors to promote the growth of these cells. Anti-androgens inhibit the ability of the receptors to bind with the androgens which then reduces the ability of the prostate cancer cells to grow. Bdenza capsules also interfere with the androgens from working within the prostate cancer cells.

Bdenza is a class of medication belongs to antiandrogen. Antiandrogens are substances which stops the effects of testosterone. Prostate Cancer which depends on the male hormone testosterone or growth of its related androgens. If the number of androgens is decreased it is possible to slow down or shrink the cancer.


Rapid absorbs from GI tract. Time to peak plasma concentration is 1 hour (range 0.5 to 3 hours).

Human serum protein concentration is 97% to 98% and for active metabolite is 95% to plasma protein. Volume of distribution is 100L.

Metabolized primarily in hepatic through CYP2C8 and CYP3A4

Excreted via urine 71%, and feces 14% Half-life elimination is 5.8 days and N- desmethyl enzalutamide is 7.8 to 8.6 days.

Brand Bdenza
Ingredients Enzalutamide
Strength 40mg
Manufactured BDR


Bdenza dose recommended for the patient is 160mg which have been administer as four capsules of Bdenza 40mg. Bdenza 40mg is given orally and once in a day Bdenza 40mg can be taken with or without regard to food Swallow the whole capsule Do not dissolve, chew or open the capsules.

Over dosage

In overdose condition treatment with Bdenza 40mg solid be stop and provide supportive measures care and monitor the vital signs. Multiple dose If administer ≤ 240mg no seizures is reported but when taking 360mg,480mg, and 600mg daily then 3 seizures were absorbed. If overdose occur, the patient will have high risk of seizures.

More common

Back pain; bloating of the face, arms, hands, lower legs or feet; bloody urine; blurred vision; breathing difficulty; dizziness; loss of bowel control; nervousness.

Less common

anxiety; confusion or excitement; nightmares; span problems; itching skin; pale-colored urine.

Rare side effects



While receiving Bdenza drug the risk of seizure will develop in patients and by sudden loss of consciousness will leads harm to themselves. Inform the doctor If you have any symptoms of seizures.

If you had any neurological disorder like headache, lethargy, confusion and other visual with or without hypertension. Inform the doctor and he will discontinue the drug.


  • Bdenza Capsule interact with moderate to strong inducer of CYP3A4, CYP2C9 and CYP2C19 will cause High potential relevant drug interaction.
  • Bdenza capsule interact with inhibitors and inducers of CYP2C8 and CYP3A4 will cause Circulating concentration of enzalutamide.
  • Bdenza capsules interact with aromatase inhibitor sanastrozole reduce their effectiveness.


Bdenza is contraindicated in women during pregnancy it may cause fetal harm to death.

Bdenza capsule is unsafe to use during pregnancy because the drug may cause harm to the fetal and possibility loss of pregnancy. The drug Bdenza is not recommended for use in females. In lower dose itself when administrating to pregnant mice during organogenesis caused adverse reaction to the fetal than dose recommended in human dose.

No information regarding the presence of Bdenza in human milk, so using of this drug is unsafe for the breastfed infant

Store the drug at 20°C to 25°C. Keep the drug in dry place Keep the container closed tightly

If you missed a dose take it as soon as possible, before next dose time, then swap missed dose and continue regular schedule. Do not have 2 doses at a time. Take advice from the doctor.

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