BEVACIREL 400MG

Bevacirel is a brand name of Bevacizumab, categorized as monoclonal anti-body & anti-angiogenesis
Bevacirel is a combined human monoclonal antibody IgG1, that predicament to and prohibits the biological activity of human vascular endothelial growth factor (VEGF) .

Bevacizumab

Bevacirel

400mg

Reliance life science




INDICATION

Bevacirel is used in the treatment of;
Metastatic colon or rectal cancer:
In combination with 5-fluorouracil chemotherapy administered intravenously, first or second line drug of choice
Non-squamous, non-small cell lung cancer:
Concurrent use with carboplatin and paclitaxel as first line therapy
Glioblastoma:
Used in the treatment of recurrent Glioblastoma in adults
Metastatic renal cell cancer:
Concurrent use with interferon alfa
Metastatic cervical cancer:
Concurrent use with paclitaxel & cisplatin or paclitaxel & topotecan
Epithelial ovarian, fallopian tube or peritoneal cancer:
In concomitant use with paclitaxel, pegylated liposomal doxorubicin or topotecan

Mechanism of action

Bevacirel comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells
This interaction prevents endothelial cell multiplication and new blood vessel production occurs
Thus in counts discontinuation of metastatic tumor cells growth happens



ADME Properties

The pharmacokinetic form of Bevacirel is assayed by measuring total serum Bevacizumab concentration.

The volume of distribution is 2.9 (22%) L

The terminal half life period of Bevacizumab is 20days (11 to 50days)

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drug
Brand Bevacirel
Ingredients Bevacizumab
Strength 400mg/16ml
Manufactured Reliance life science
Rating

Key point:
Bevacirel do not administered before at least 28 days following surgery and the wound is completely cured
Metastatic colorectal carcinoma:
The prescribed dosage of Bevacirel by concomitant with 5-fluorouracil based chemotherapy
5mg/kg of Bevacirel for every 2 weeks IV in concomitant with bolus IFL
10mg/kg of Bevacirel for every 2 weeks IV in combination with FOLFOX4
5mg/kg IV Bevacirel for every 2 weeks or 7.5 mg/kg Bevacirel as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy
Non-small cell lung cancer:
The recommended dosage of Bevacirel is 15mg/kg IV for every 3 weeks by combining with carboplatin and paclitaxel
Glioblastoma:
10mg/kg of Bevacirel administered IV for every 2 weeks
Metastatic renal cell cancer:
The prescribed dosage of Bevacirel is 10mg/kg IV for every 2 weeks by concurrent use with interferon alfa
Metastatic cervical cancer:
The prescribed dosage of Bevacirel; 15mg/kg of Bevacirel given intravenously for every 3 weeks by combining with paclitaxel and cisplatin or with paclitaxel and topotecan
Epithelial ovarian, fallopian tube or peritoneal cancer:
Platinum opposing:
The recommended dosage of Bevacirel; 10mg/kg of Bevacirel for every 2 weeks by concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan
Or The recommended dosage of Bevacirel; 15mg/kg of Bevacirel given through IV for every 3 weeks by combining with topotecan Platinum responsive
The recommended dosage of Bevacirel; 15mg/kg given IV for 3 weeks in concomitant with carboplatin and paclitaxel for 6 to 8 cycles
The recommended dosage of Bevacirel; 15mg/kg of Bevacirel given IV for 3 weeks by combining with gemcitabine & carboplatin for 6 to 10 cycles
Preparation & administration:
Bevacirel is intravenous solution
At initial infusion: given IV infusion over 90 minutes
Following infusions: give second infusion over 60 minutes, if tolerated
Administer all following infusion over 30minutes
Bevacirel IV infusion is prepared in aseptic condition
Bevacirel 400mg containing 16ml solution whereas 100mg containing 4ml
Bevacirel dilute into 100ml of 0.9% NS
Do not dilute with dextrose solution
Discard the remaining portion which is left in a vial.

Gastrointestinal perforation and fistulae
Surgery and wound healing complication
Hemorrhage
Arterial thromboembolic events
Venous thromboembolic events
Hypertension
Posterior reversible encephalopathy syndrome
Renal injury & Proteinuria
Infusion reactions
Ovarian failure
Congestive heart failure
Neutropenia, mucosal inflammation, infection, neuropathy, Epistaxis, erythrodysaesthesia.

Caution with use in the conditions like;
While using Bevacirel these are some complications occurred during therapy, care should be taken
Hypertension
Posterior reversible encephalopathy syndrome
Gastrointestinal perforations
Wound healing complications
Hemorrhage
Arterial thromboembolic events
Venous thromboembolic events
Embryo fetal toxicity occurs.

DRUG – DRUG INTERACTION

  • While administering Bevacirel with paclitaxel & carboplatin, causes decrease in exposure of paclitaxel after four cycles of therapy
  • While getting patients with paclitaxel & carboplatin leads to increase the paclitaxel exposure at day 6

Contraindications

No contraindication occurred



Pregnancy category: D
Bevacirel should not be used in pregnancy condition.

Breast feeding is also not recommended

Bevacirel vial should be stored at 2 to 8°C (36 to 46°F)
Single use vial.

If patient fail to take the dose or missed the cycle means must consult with oncologist and follow the regular dosing schedule.
Do not take overdose

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