Cometriq 20mg is indicated for the treatment of metastatic medullary thyroid cancer and for the treatment of patients having advanced renal cell carcinoma (RCC) who have getting before anti-angiogenic therapy.



30 tablets


Cometriq 20mg belongs to targeted therapy drug used to cure medullary thyroid cancer and kidney cancer that has spread

Cometriq 20mg label includes a black box warning of gastrointestinal perforations, fistulas, and haemorrhage.

Cometriq 20mg is a prescription drug which is used under the supervision of doctors

Mechanism of action

Cabozantinib belongs to a type of targeted therapy drug known as tyrosine kinase inhibitor. It action by inhibiting the signals inner cancer cells which made them grow and divide. This may help to block or reduced the growth of the cancer. It can also prohibit new blood vessels growing in the cancer. Cancer cells require to make new blood vessels, so they can develop and spread.


Peak plasma concentration is observed in 2-5 hours

Human plasma protein bounding of Cometriq is ≥ 99.7%

Mostly metabolized by CYP3A4 and minorly by CYP2C9

Eliminated mostly via feces 54 % and in urine 27% and half-life is 55 hours


Ingredients Cabozantinib
Strength 20mg
Pack 30 tablets

Avoid substitute Cometriq tablets with Cabozantinib capsules.
The prescribed dose of Cometriq is 140mg (one 80mg and three 20mg).
Administration Cometriq is without food.
Advise the patients not to eat for at least 2 hours before and 1 hour after taking cometriq. Follow the treatment until patient no longer experiences clinical benefit or experiences unacceptable toxicity.
Swallow Cometriq tablets whole. Do not crush Cometriq tablets.

Side effects

• Haemorrhage
• GI perforations and fistulas
• Thrombotic events
• Hypertension and hypertensive crisis
• Diarrhea
• Palmar-plantar erythrodysesthesia
• Reversible posterior leukoencephalopathy syndrome


Check the patients for symptoms of perforations and fistulas, contain abscess. stop Cometriq 20mg in patients who experience a perforation or a fistula.
Avoid administer Cometriq 20mg to patients with a present history of haemorrhage or haemoptysis.
Stop the Cometriq 20mg in patients who develop an acute myocardial infarction, cerebral infarction, or any other clinically significant arterial thromboembolic complication.
Stop the Cometriq 20mg for patient if have severe hypertension that cannot be controlled with anti-hypertensive therapy.
Inform pregnant women about potential risk to a foetus. Advise females of reproductive possible to use efficient contraception during treatment with Cometriq 20mg and for 4 months after the last dose


  • While interaction with strong CYP3A4 inhibitor will increase the single dose plasma Cometriq 20mg exposure by 38%.
  • While interaction with strong CYP3A4 inducers will decreased the single dose plasma Cometriq 20mg exposure by 77%
  • Combination with MRP2 inhibitors may increase the exposure to Cometriq 20mg


Cometriq 20mg is contraindicated patients having hypersensitivity reaction to the active substance or its excipients.

Based on studies of animal and mechanism of action, Cometriq 20mg will cause fetal harm when given to pregnant women
Advice the female not to become pregnant while on treatment with Cometriq 20mg

During treatment with Cometriq 20mg, advise the women not to breastfed to infants

Store the drug at below 25°C Keep away from the children resistances

If the patient vomits after taking a dose of Cometriq 20mg or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose. Do not take the missed dose within 12 hours of next dose.

Quick Contact

Prescription upload

PRESCRIPTION , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines. will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website. requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from

At , a Caregiver can order prescription medicines on your behalf.