CABOZANTINIB 40MG

Cabometyx 40mg is indicated for the treatment of metastatic medullary thyroid cancer and for the treatment of patients having advanced renal cell carcinoma (RCC) who have getting before anti-angiogenic therapy.

Cabozantinib

40mg

30 tablets




DESCRIPTION

Cabometyx 40mg belongs to targeted therapy drug used to cure medullary thyroid cancer and kidney cancer that has spread
Cabometyx 40mg label includes a black box warning of gastrointestinal perforations, fistulas, and haemorrhage.
Cabometyx 40mg is a prescription drug which is used under the supervision of doctors

Mechanism of action

Cabozantinib belongs to a type of targeted therapy drug known as tyrosine kinase inhibitor. It action by inhibiting the signals inner cancer cells which made them grow and divide. This may help to block or reduced the growth of the cancer. It can also prohibit new blood vessels growing in the cancer. Cancer cells require to make new blood vessels, so they can develop and spread.



Pharmacokinetic

Peak plasma concentration is observed in 2-5 hours

Human plasma protein bounding of Cabometyx is ≥ 99.7%

Mostly metabolized by CYP3A4 and minorly by CYP2C9

Eliminated mostly via feces 54 % and in urine 27% and half-life is 55 hours



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cabozantinib-40mg

Ingredients Cabozantinib
Strength 40mg
Pack 30 tablets
Rating

Avoid substitute Cabometyx tablets with Cabozantinib capsules.
The prescribed dose of Cabometyx is 60 mg.
Administration Cabometyx is without food.
Advise the patients not to eat for at least 2 hours before and 1 hour after taking cabometyx. Follow the treatment until patient no longer experiences clinical benefit or experiences unacceptable toxicity.
Swallow Cabometyx tablets whole. Do not crush Cabometyx tablets.

Side effects

• Haemorrhage
• GI perforations and fistulas
• Thrombotic events
• Hypertension and hypertensive crisis
• Diarrhea
• Palmar-plantar erythrodysesthesia
• Reversible posterior leukoencephalopathy syndrome

Precautions

Check the patients for symptoms of perforations and fistulas, contain abscess. stop Cabometyx 40mg in patients who experience a perforation or a fistula.
Avoid administerCabometyx 20mg to patients with a present history of haemorrhage or haemoptysis.
Stop theCabometyx 20mg in patients who develop an acute myocardial infarction, cerebral infarction, or any other clinically significant arterial thromboembolic complication.
Stop the Cabometyx 40mg for patient if have severe hypertension that cannot be controlled with anti-hypertensive therapy.
Inform pregnant women about potential risk to a foetus. Advise females of reproductive possible to use efficient contraception during treatment with Cabometyx 40mg and for 4 months after the last dose

DRUG – DRUG INTERACTION

  • While interaction with strong CYP3A4 inhibitor will increase the single dose plasma Cabometyx 40mg exposure by 38%.
  • While interaction with strong CYP3A4 inducers will decreased the single dose plasma Cabometyx 40mg exposure by 77%
  • Combination with MRP2 inhibitors may increase the exposure to Cabometyx 20mg

Contraindications

Cabometyx 40mg is contraindicated patients having hypersensitivity reaction to the active substance or its excipients.




Based on studies of animal and mechanism of action, Cabometyx 40mg will cause fetal harm when given to pregnant women
Advice the female not to become pregnant while on treatment with Cabometyx 40mg

During treatment with Cabometyx 40mg, advise the women not to breastfed to infants

Store the drug at below 25°C Keep away from the children resistances

If the patient vomits after taking a dose of Cabometyx 40mg or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose. Do not take the missed dose within 12 hours of next dose.


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