Capnat

Capnat - (fluoropyrimidine carbamate) with anti-tumor activity Capnat is a prodrug of 5’-deoxy-5-fluorouridine (5’-DFUR) which is changed to 5 fluoro uracil. Capnat is generally administered orally. Capnat is also have anti-metabolite activity

Capecitabine

Capnat

500mg

Natco





Capnat indication

Colorectal cancer Adjuvant treatment in Duke’s colon cancer First line therapy in colon-rectal cancer metastasis Breast cancer In metastatic breast cancer: used in combination with docetaxel after failure of anthracycline containing chemotherapy

Mechanism of action

Capecitabine is a prodrug, it is metabolizing to 5-FU. In both non-cancer and cancer cells, 5-FU is metabolized in to 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) These two metabolites cause injury to the tumor cells by two major ways FdUMP and the folate cofactor (N5-10-methylenetetrahydrofolate), which binds to thymidylate synthase (TS) to form covalently bound ternary complex.

This binding prohibits the production of thymidylate from 2’-deaxyuridylate Thymidylate an important messenger of thymidylate triphosphate. It is essential for DNA synthesis; therefore, insufficiency of this compound leads to inhibit cell division Nuclear transcriptional enzymes can falsely inserted FUTP alternative to uridine triphosphate during RNA synthesis. This metabolic failure can hinder with RNA conversion and protein synthesis via assembly of counterfeit RNA




PHARMACOKINETIC

Capecitabine reaches the peak plasma level at about 1.5 hours Food decreased both the rate and duration of absorption of Capnat with mean Cmax and AUC0-∞ reduced by 60% and 35% respectively

The human plasma protein bound to Capecitabine is occurs in less than 60%

Capecitabine is largely metabolized to 5-FU enzymatically. In liver, 60 kDa carboxylesterase hydrolyses to 5’-deoxy-5-fluorocytidine. Cytidine deaminase is an enzyme which converts 5’-DFCR to 5’-DFUR. Thymidine phosphorylase is also an enzyme which involved in the conversion of 5’-DFUR to 5-FU active drug

The route of elimination of Capecitabine is occurred through urine 95.5% The mean terminal half-life period of Capecitabine is 0.75 hour





Blueberrypharma.com-img1

Capnat 500mg
Brand Capnat
Ingredients Capecitabine
Strength 500mg
Manufactured Natco
Rating


Monotherapy

First line therapy of patients with advanced colorectal cancer

The usual dose of Capnat is 1250mg/m2 should be taken orally as twice daily (morning and evening dose 2500mg/m2); therapy continue for 2 weeks followed by 1-week rest period given as 3 weeks cycle

Adjuvant therapy for Duke’s colon cancer

The usual dose of Capnat is 1250mg/m2 orally as twice daily (morning and evening dose 2500mg/m2); for 2 weeks followed by 1 week given as 3 weeks for total 8 cycles (24 weeks)

Breast cancer

Monotherapy: Recommended dose: 1250mg/m2 should be taken as orally for twice daily In combination with docetaxel; 1250mg/m2 of Capnat with 75mg/m2 of docetaxel for 3 weeks Capnat should be administered within 30 minutes after a meal

In pediatric

The safety and efficacy of the Capnat tablets in pediatric patients has not been established

10%:

Diarrhea, nausea, anemia, Lymphopenia, head and foot syndrome, edema, fatigue, fever, headache, pain, paresthesia, alopecia, dermatitis, abdominal pain, anorexia, loss of appetite, constipation, dyspepsia, stomatitis, vomiting, neutropenia, thrombocytopenia, dyspnea, bilirubin decreased, eye irritation

1-10%:

Chest pain, dermatitis, Pruritus, rash, dizziness, headache, weakness, dehydration, dry mouth, dyspepsia, taste disturbance, back pain Post marketing reports: Toxic leukoencephalopathy

Coagulopathy

concomitant with warfarin, anti-coagulant response should be monitored

Diarrhea

patients with severe diarrhea should be monitored

Cardio toxicity

while taking Capnat , cardio toxicity occurs like; myocardial infarction, angina, dyshythmias, cardiac arrest sudden death, Cardiomyopathy Dihydropyrimidine dehydrogenase deficiency, Dehydration and renal failure, Embryo fetal toxicity, Mucocutaneous and dermatologic toxicity, Hyperbilirubinemia, Hematological problems, Care should be taken while using in geriatric patients, Hepatic insufficiency


Drug- drug interaction



  • Anticoagulant: Capnat concomitant with warfarin and phenprocoumon, bleeding occurs. These events occurred within several days and even a month also
  • Phenytoin: combination of phenytoin and Capnat , toxicity related to elevation of phenytoin levels
  • Leucovorin: the toxicity and concentration of 5-FU increased by Leucovorin. In elderly patients, phenytoin and Leucovorin is administered weekly which may cause; diarrhea, dehydration, enterocolitis which may causes death.
  • CYP2C9 substrate: other than warfarin, there is no drug interaction occurs while concomitant with CYP2C9 substrates
  • Drug-food interaction: In case of administering Capnat with food, it leads to reduce the rate and duration of absorption of Capnat. Capnat tablets should be administered within 30 minutes after food




Contraindications

Capnat is contraindicated to renal impairment patients

Capnat is contraindicated in patients with hypersensitivity to Capnat or other components




Pregnancy category: D Capnat may cause harm to the fetus Generally, Capnat should not be recommended in pregnancy or women who are become pregnant Breast feeding is not recommended

Capnat should be stored at 20°C to 25°C (68°F to 77°F)

If patient fail to take the dose of Capnat , must consult with medical oncologist and follow the suggestions Do not self-medicate. The missed dose must be skipped and follow the regular dosing schedule Do not double the dose

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.