Caprelsa 300mg

Caprelsa 300mg is indicated for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

Vandetanib

Caprelsa

300mg

Genzyme Corp




Description

Vandetanib is a generic form of brand name Caprelsa 300mg which is a prescription medication required to treat patients with medullary thyroid cancer (MTC) which cannot be taken out by surgery or that has spread to other parts of the body, and in which the tumor are developing or causing symptoms. This type of medullary thyroid cancer is usually called advanced medullary thyroid cancer (aMTC).
In which the drug takes a long time to get eradicate of Caprelsa 100mgfrom your body and you may be at risk for adverse reaction related to Caprelsa 100mgafter you have stopped your treatment.

Mechanism of action

Caprelsa 300mg is a type which belongs to kinase inhibitor. A kinase is a kind of enzyme which can indicate other molecules in a cell, contain a cancer cell, to form active. Caprelsa 300mg prohibits the cell communication and may inhibits tumor growth. It's also important to note that regular cells can be affected by your treatment with Caprelsa 100mg, which could cause in side effects.



Pharmacokinetic

Time to peak plasma concentration is 6 hr (range 4-10 hr) and steady state is 3 months

Bounding of plasma protein is 90% and volume of distribution is 7450L

Caprelsa 300mg is metabolized by CYP3A4

The drug elimination through feces 44% and via urine collection period of 21 day after single dose.



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drug
Brand Caprelsa
Ingredients Vandetanib
Strength 300mg
Manufactured Genzyme Corp
Rating

The recommended dose of Caprelsa is 300mg administrated orally once daily until disease progression or unacceptable toxicity occurs
Avoid crushing of tablets, disperse the tablet in 2 ounces of water by stirring 10 minutes approximately. Be careful, do not use other liquids for dispersion and swallow the medicine soon after dispersion, if any remaining residue with 4 additional ounces of water and swallow.
Th dispersion liquid can be administrated via nasogastric or gastrostomy tubes.

Side effects

Headache, Fatigue, Low blood sugar, Abdominal pain, Poor appetite, Low white blood cell count, Kidney problems, Dry skin, Vomiting, Weakness, Irregular heart beat, Insomnia (difficulty sleeping), Photosensitivity (sensitivity to sunlight), Bleeding, Anemia, Liver tests increased (bilirubin), Itching, Heartburn, Cough, Upper respiratory infection, Depression, Weight loss, Diarrhea, Rash, Elevated Liver Enzymes (ALT), Low calcium levels, Acne, High blood pressure, Nausea.

Precautions

Effective CYP3A4 inducers decreased exposure to Vandetanib by up to 40%; however, no clinically significant effect on exposure to Vandetanib was observed in the presence of the potent CYP3A4 inhibitors.
Fatal skin reactions, containing Stevens-Johnson syndrome and serious toxic epidermal necrolysis resulted; systemic treatment such as corticosteroids may be needed; permanently stop therapy for severe skin reactions.
Interstitial lung disease (ILD), causes in death has been reported; interfere withVandetanib and examine unexplained Dyspnea, cough, and fever; applicable measures should be taken for ILD
Ischemic cerebrovascular events, haemorrhage, heart failure, diarrhea, hypothyroidism, hypertension, and reversible posterior leukoencephalopathy syndrome, have been observed
Can cause risk of fetal when administered to pregnant women; Do not get pregnancy while gettingVandetanib and for 4 months following treatment

DRUG – DRUG INTERACTION

  • While combination with a strong CYP3A4 inducer will decreased Vandetanib plasma concentration. Hence avoid concomitant use of known strong CYP3A4 inducers during Caprelsa 300mg treatment.
  • When administrating Caprelsa 300mg with drugs that are transported by OCT2 will increased plasma concentration of metformin.
  • When administering Caprelsa 300mg with digoxin will increased plasma concentration of digoxin.
  • Avoid combination use of Caprelsa 300mg with agents which may prolong the QT interval.

Contraindications

Hypersentivity
Pregnancy - the drug cause risk to fetal




Caprelsa 300mg is embryotoxic and fetotoxic, due to pharmacological action treatment will causes harm to fetal when administered to a pregnant woman

Advise females not to breastfeed during treatment and for 4 months after final dose.

Caprelsa 300mg tablets should be stored at 25°C.
Protect the drug from light.

If dose is missed, then take the dose as soon as possible before reach of next dose time or skip the missed dose and follow the normal schedule. Do not have extra dose which leads to over dosage. Avoid taking missed dose within 12 hours of the next dose. Consult the doctor about missed dose and overdose


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