Celofos 2gm

Ifosfamide is generic form of brand name Celofos Celofos 2gm belongs to type of anti-cancer drug. This medication is classified as an "alkylating agent.
Celofos is a prescription drug which is used under the supervision of medical oncologist

Ifosfamide

Celofos

2gm

Celon Laboratories Ltd




INDICATION

Celofos 2gm is indicated for the treatment of following conditions;
• Relapsed testicular cancer and germ cell tumors
• Sarcomas (soft-tissue, osteogenic sarcoma, Ewing's sarcoma)
• Non-Hodgkin's lymphoma
• Hodgkin's disease
• Non-small cell and small cell lung cancer
• Bladder cancer
• Head and neck cancer
• Cervix cancer

MECHANISM

The proper mechanism of Ifosfamide has not been described butoccur to be like other alkylating agents. Ifosfamide needed biotransformation in the Hepatic by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of Ifosfamide alkylate or mix with many intracellular molecular structures, containing nucleic acids. The cytotoxic activities are mainly via the alkylation of DNA, done by affix the N-7 position of guanine to its reactive electrophilic groups. The inter and intra strand cross-links formation in the DNA causes in cell death.



Pharmacokinetic

Time to peak plasma of Celofos is 20-30 minutes and the bioavailability are 90-100%

volume of distribution is 33L

Celofos is extensively metabolized and has metabolites of 3-dechloroethylifosfamide, 2- dechloroethylifosfamide and carboxyifosfamide

Celofos is excreted at high dose of 5000mg/m2 in urine 70-86% and at low dose 1600-2400 about 12-16%.
Half- life for high dose of 3800-5000mg/m2is 15hr and 7hr for low dose of 1800-2400 mg/m2




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drug
Brand Ifosfamide
Ingredients Celofos
Strength 2gm
Manufactured Celon Laboratories Ltd
Rating

DOSAGE AND ADMINISTRATION

For testicular cancer :
Usual adult dose is 1.2 g/m2, diluted to 50mg/mL IV over 30 minutes once a day with mesna administrated via IV, Oral, or continuous IV infusion given just before and 4 and 8 hours after each dose and aggressive hydration 2 to 4 L/day. Celofos is commonly administrated for 5days.
Repeated every 3 to 4 weeks
For cervical cancer :
The recommended dose in combination with other cancer drugs as a part of the BIP regimen is 5000mg/m2 over 24 hours on day 2 Cycle repeated every 21 days
The recommended dose in combination with other cancer drugs as a part of the BIC regimen is 2000mg/m2IV on day 1 through 3 Cycle repeated every 21 days
Paediatric dose for Malignant disease :
The recommended dose is 1200 to 1800mg/m2IV for 3 to 5 days every 21 to 28 days
Or administrated has 5000mg/m2 over 24 hours infusion or 3g/m2/ day for 2 days

SIDE EFFECTS

Common side effects of Celofos 2gm :
• Alopecia
• Malaise
• Dysphagia
• Low WBC count
• Low platelet count
• Loss of hair
• Menopause
• Fertility loss
• Vomiting and nausea
• Hypotension
Less common side effects of Celofos 2gm :
• Central neurotoxicity

PRECAUTIONS

While treatment with Celofos 2gm may occur Bone marrow suppression
With Celofos 2gm causes Haemorrhagic cystitis reported
Stop treatment if it occurs Confusion and coma due to CNS toxicity have been associated with therapy.
Dose-related serious myelosuppression occurred

DRUG – DRUG INTERACTION

  • When Celofos 2gm combination with CYP3A4 inducers may increase the metabolism of Ifosfamide to its active alkylating metabolites

  • When Celofos 2gm combination with CYP3A4 inhibitors may decrease the metabolism of Ifosfamide to its active alkylating metabolites perhaps reducing the effectiveness of Ifosfamide treatment

Contraindications


Celofos 2gm is contraindicated as follows;
Known hypersensitivity
Urinary outflow obstruction



Celofos 2gm will have pregnancy category
Advice the pregnant women about potential hazard to the fetus and using during pregnancy time is contraindicated

Avoid breastfeed during the treatment with Celofos 2gm because potential hazard to the fetus may occur

Store the Celofos 2gm 2°C to 8°C.

If the patient fails to take a dose of drug or missed to take a dose, then should not take an extra dose, but to take the next dose at the regular time, leave the missed dose.

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