Crizalk 200mg is used for the therapy of patients with metastatic non-small cell lung cancer.



60 capsules


Crizalk 200mg belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction.
Crizalk 200mg inhibits the anaplastic lymphoma kinase (ALK) and the c-MET/hepatocyte growth factor receptor. This action disturbs certain pathways in the cell, which can inhibit the growth of tumor cells.
Crizalk 200mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene.

Mechanism of action

More specifically, crizotinib inhibits anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON).
Deformity in the ALK gene result by mutations or translocations may causes expression of oncogenic fusion proteins. Certain patients with NSCLC, they have the EML4-ALK gene.
Crizotinib prohibits ALK tyrosine kinase which basically results in reducedmultiplication of cells which carry the genetic mutation and tumour survivability.


Peak plasma concentration is 4 to 6 hours and bioavailability were 43%.

Volume of distribution is 1772L and plasma protein bounding is 91%

Crizalk metabolised by CYP3A4 and CYP3A5

Crizalk is excreted via feces 63% and 22% via urine and half -life is 42 hours


Ingredients Crizotinib
Strength 200mg
Pack 60 capsules

Select patients for the treatment with Crizalk based on ALK or ROS1 presences in tumor specimens.
The recommended dosage of Crizalk is 250mg orally twice in a day
Administer the Crizalk dose with or without food, until disease progression. Dosage modification :
Crizalk 200 mg taken orally twice daily for First dose reduction
Crizalk250 mg taken orally once daily for Second dose reduction
Permanently discontinue if unable to tolerate Crizalk250 mg taken orally once daily.

Crizotinib Side effects

• Infection increased
• Breathlessness
• Eyesight changes
• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• bradycardia


Before using Crizalk in some condition, consult with doctor.
Interstitial lung disease/pneumonitis
QT interval prolongation
Severe visual loss
Embryo-fetal toxicity.


  • Combination with strong or moderate CYP3A4 inhibitors will increase Crizalk plasma concentration
  • Crizalk interaction with strong CYP3A inducers will decrease crizalk plasma concentration
  • Interaction with CYP3A substrates will increase plasma concentration of CYP3A substrates
  • Do not use combination with bradycardia causing drugs



Based on studies of animal and mechanism of action, Crizalk 200mg will cause fetal harm when given to pregnant women
Advice the female not to become pregnant while on treatment with Crizalk 200mg

During treatment with Crizalk 200mg, advise the women not to breastfed to infants

Stored at 20°C - 25°C.

If the patient vomits after taking a dose of cabometyx 20mg or missed to take a dose, then should not to take an extra crizotinib dose, but to take the next at the regular time, skip the missed dose.

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