Daunoplus 20mg

Daunoplus is a very toxic anthracycline aminoglycoside anticancer isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Daunoplus is a prescription drug provided under the guidance of medical oncologist

Daunorubicin

Daunoplus

20mg

Vhb Life sciences Inc




INDICATION

Daunoplus is indicated for the treatment of following condition;
• Myelogenous leukemia
• Lymphoblastic Leukemia
• Promyelocytic leukemia

MECHANISM

Daunorubicin belongs to classification known as an antineoplastic antibiotic. It stops an enzyme called topoisomerase 2, so the cancer cell's DNA gets twisted up and the cell can't divide into 2 new cells.



Pharmacokinetic

The drug Daunoplus has protein bound about 50-60% and volume of distribution is 20-39.2L/kg

Daunoplus is metabolized in hepatic and the metabolites is Daunorubicinol

Drug excreted via feces 40% and urine 25%
Half-life is 14-20 hr for parent drug, 24-48 for Daunorubicinol




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drug
Brand Daunoplus
Ingredients Daunorubicin
Strength 20mg
Manufactured Vhb Life sciences Inc
Rating

DOSAGE AND ADMINISTRATION

Acute Nonlymphocytic Leukemia :
The recommended dose in combination with cytarabine 100mg/m2/day IV for 7 days first course, for 5 days consequent course.
Then, if patient is <60 years old: 45mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
if patient is >60 years old: 30mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
Monitor the patients cardiac, renal, hepatic function
Acute Lymphocytic Leukemia :
The recommended dose is 45mg/m2 IVP days1,2,3
Monitor the patients cardiac, renal, hepatic function

SIDE EFFECTS

Common side effects :
Pain in medication was given site
Urine may appear red-brown or orange
Reduced blood counts
Nausea or vomiting
Mouth sores
Loss of hair on the scalp
Less common side effect :
Diarrhea
Problems with fertility
Radiation recall
Discoloration of nails beds

PRECAUTIONS

When using the drug Daunoplus the risk of serious cardiotoxicity (involving CHF) & myelosuppression
The Daunoplus should use with Caution in hepatic/renal impairment patients
The drug causes cardiotoxic effects in children may be more sensitive than adults
Avoid pregnancy
Secondary leukaemia’s resulted when used in concomitant use with radiation or chemotherapy

DRUG – DRUG INTERACTION

  • The effects of adenovirus types 4 and 7 live decreases by using Daunoplus and pharmacodynamic antagonism. Avoid usage of drug

  • When interaction with eliglustat will leads increase levels of Daunoplus by P- glycoprotein efflux transporter. Avoid the drug

  • When Daunoplus interaction with tofacitinib will either increases toxicity of the other by immunosuppressive effects.

Contraindications


Hypersensitivity



Pregnancy category is D
The drug causes fetal harm when administrating pregnant women

Avoid the breastfeeding during treatment with

Store the unopened vials at 2°C to 8°C.
Store the prepared solution at 20°C to 25°C.
Protect the drug from light and moisture
Retain in carton until time of use

If the patients forgot to take a dose, then have the dose as soon as you remember before next dose timing or else skip the missed dose and follow normal schedule.
Consult the doctor

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