Daunocin is a very toxic anthracycline aminoglycoside anticancer isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Daunocin is a prescription drug provided under the guidance of medical oncologist



1ml injection in a vial


Daunocin is indicated for the treatment of following condition;
• Myelogenous leukemia
• Lymphoblastic Leukemia
• Promyelocytic leukemia


Daunorubicin belongs to classification known as an antineoplastic antibiotic. It stops an enzyme called topoisomerase 2, so the cancer cell's DNA gets twisted up and the cell can't divide into 2 new cells.


The drug Daunocin has protein bound about 50-60% and volume of distribution is 20-39.2L/kg

Drug Daunocin has protein bound about 50-60% and volume of distribution is 20-39.2L/kg

Drug excreted via feces 40% and urine 25%
Half-life is 14-20 hr for parent drug, 24-48 for Daunorubicinol



Ingredients Daunorubicin
Strength 20mg
Pack 1ml injection in a vial


Acute Nonlymphocytic Leukemia :
The recommended dose in combination with cytarabine 100mg/m2/day IV for 7 days first course, for 5 days consequent course.
Then, if patient is <60 years old: 45mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
if patient is >60 years old: 30mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
Monitor the patients cardiac, renal, hepatic function
Acute Lymphocytic Leukemia :
The recommended dose is 45mg/m2 IVP days1,2,3
Monitor the patients cardiac, renal, hepatic function


Common side effects :
Pain in medication was given site
Urine may appear red-brown or orange
Reduced blood counts
Nausea or vomiting
Mouth sores
Loss of hair on the scalp
Less common side effect :
Problems with fertility
Radiation recall
Discoloration of nails beds


When using the drug Daunocin the risk of serious cardiotoxicity (involving CHF) & myelosuppression
The Daunocin should use with Caution in hepatic/renal impairment patients
The drug causes cardiotoxic effects in children may be more sensitive than adults
Avoid pregnancy
Secondary leukaemia’s resulted when used in concomitant use with radiation or chemotherapy


  • The effects of adenovirus types 4 and 7 live decreases by using Daunocin and pharmacodynamic antagonism. Avoid usage of drug

  • When interaction with eliglustat will leads increase levels of Daunocin by P- glycoprotein efflux transporter. Avoid the drug

  • When Daunocin interaction with tofacitinib will either increases toxicity of the other by immunosuppressive effects.



Pregnancy category is D
The drug causes fetal harm when administrating pregnant women

Avoid the breastfeeding during treatment with

Store the unopened vials at 2°C to 8°C.
Store the prepared solution at 20°C to 25°C.
Protect the drug from light and moisture
Retain in carton until time of use

If the patients forgot to take a dose, then have the dose as soon as you remember before next dose timing or else skip the missed dose and follow normal schedule.
Consult the doctor


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