Empetus tablets are anti-retroviral medication which containing an active moiety known as Ritonavir. Empetus is classified as HIV protease inhibitor drug, which is peptidomimetic agent containing both HIV-1 & HIV-2 protease inhibitor activity. Empetus is also a CYP3A inhibitor. Empetus is exhibits anti-retroviral activity by interceding with reproductive cycles of HIV.





Usage of Empetus 100mg

Empetus tablets are primarily indicated for treatment of HIV-1 infection by combining with other anti-retroviral medications.

Mechanism of Empetus 100mg

Empetus is a peptidomimetic prohibitor of the HIV-1 protease. Prevention of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which causes production of non-infectious immature HIV particles.


The maximum plasma concentration time of ritonavir after the dose administration, causes within 2 hours & 4 hours relatively in both fasted &non fasted state. Food will decrease the bioavailability slightly.

Volume of distribution is 20 to 40L Nearly 98 to 99% of drug ritonavir is binds to human plasma protein.

Isopropylthiazole oxidation is the major metabolite of ritonavir and it is similar in action of ritonavir. CYP3A is a major isoenzymes involved in the metabolism of ritonavir.

The excretion of ritonavir should be occurs through urine & feces as an unchanged form The ritonavir half life period is 3 to 5 hours


Brand Empetus
Ingredients Ritonavir
Strength 100Mg
Manufactured Emcure

Administration and Dosage regimens of Empetus 100mg

The prescribed doses of Empetus for adults are:
600mg should be administered orally as two times a day. Empetus tablets should be initiated by not less than 300mg as two times a day followed by increased dose at 2 to 3 days by 100mg as twice daily. The maximum dose is 600mg and it should not be exceeded.

For pediatric:
Empetus should be used by combining with other antiretroviral drugs. The prescribed dose of Empetus is 350 to 400mg/m2 as two times a day for pediatric patients with age of older than 1 month. The dose should not be exceeded to 600mg The initial dose of Empetus is 250mg/m2 two times day and increased at 2 to 3 days interal by 50mg/m2 as two times a day. Depending on body surface area, the dose should be calculated. Dose reduction is required when Empetus is combined with atazanavir, darunavir, fosamprenavir, saquinavir& tipranavir.

Over dosage

No special antidote is required for over dosage If occurs then Provide patients supportive measure to the patient with over dosage of Ritonavir. Monitor the manifestation associated to over dosage condition of Empetus . Ritonavir is intensively metabolized and largely binds to human plasma protein so hemodialysis process is not valuable for over dosage of ritonavir.

Empetus 100mg caused side effects

Edema, Gout, Increased cholesterol, Increased triglycerides Liver toxicity, Pancreatitis, Allergic reactions, Blurred vision, Abdominal pain, Hypersensitivity reactions, Lipodystrophy, Arthralgia, Myopathy, Dyspepsia, Flatulence, GI hemorrhage, Gastro esophageal reflux disease, Nausea, Vomiting, Fatigue, Increased bilirubin, Hepatitis, Myalgia, Acne, Pruritus, Rash, Flushing, Hypertension, Hematocrit, Decreased hemoglobulin, Neutropenia, Dehydration, Cushing’s syndrome, Cardiac problems, Epidermal necrolysis

Safety measures

Serious adverse reactions may occur due to drug interactions like Empetus with CYP3A inducers or inhibitors will causes Hepatic toxicity, Pancreatitis, Allergic reactions, PR interval extension, Lipid disorders, Diabetes mellitus, Immune reconstitution syndrome, Fat redistribution, Hemophilia, Cross resistance

These are all some serious effects occurred during the therapy with Empetus , to over come the problems patients must be: Provide with supportive measures Counsel about the adverse effect before starting the treatment In severe condition, stop the treatment. Maintain the lab value Patient should be frequently monitoring with the signs & symptoms associated to effects.

Drug- drug interaction

Combination of drugs which are metabolized by CYP3A causes increasing the plasma concentration of these agents. Concomitant use of Empetus with HIV-1 protease inhibitors causes increasing effect of concentration of these drugs. Empetus co administration with integrase inhibitors, causes decreasing the effect of concentration of these drugs.

Combination with analgesic causes increasing concentration of analgesics. Empetus concomitant use with anti-cancer or anti-arrhythmic drugs causes increasing the effect of concentration of these drugs. Interaction of Empetus with warfarin causes either decreasing or increasing the concentration of warfarin. Empetus interaction with anti-convulsant, anti-depressants causes increasing in concentration of these drugs.

Pregnancy category C Empetus should not be used in pregnancy & lactating period. Generally, HIV infected women should not undergo breast feeding, for avoiding the spreadness of disease to baby.

Empetus tablet container should be stored on below 30°C Protect the container away from heat, moisture & light.

In case of missed dose, patient should be consult with medical practitioner and follow the instruction given by physician. The regular dosing schedule should be retained. The missed dose leads to over dosage condition.


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