Enzamide

Enzamide capsules belongs to nonsteroidal antiandrogen drug which is indicated for use in conjunction with castration to treat metastatic castration-resistant prostate cancer (mCRPC). Enzamide capsule is in the form of liquid – filled soft gelatin capsules administer via oral route. Each capsule consists of 40mg enzalutamide in the form of solution in caprylocaproyl polyoxylglycerides.

Enzalutamide

Enzamide

40mg

Intas




WHAT Enzamide CAPSULE IS USED FOR

Enzamide 40mg capsule is an anticancer medication which used for the treatment of patients with metastatic castration resistant prostate cancer.

(i.e. surgical treatments that lower testosterone/ prostate cancer that is resistant to medical).

PHARMACOLOGY OF Enzamide CAPSULE

Prostate cells are normally called as androgen receptors. Androgens join with these receptors to promote the growth of these cells. Anti-androgens inhibit the ability of the receptors to bind with the androgens which then reduces the ability of the prostate cancer cells to grow. Enzamide capsules also interfere with the androgens from working within the prostate cancer cells.

Enzamide is a class of medication belongs to antiandrogen. Antiandrogens are substances which stops the effects of testosterone. Prostate Cancer which depends on the male hormone testosterone or growth of its related androgens. If the number of androgens is decreased it is possible to slow down or shrink the cancer.



ADME PROPERTIES

Rapid absorbs from GI tract. Time to peak plasma concentration is 1 hour (range 0.5 to 3 hours).

Human serum protein concentration is 97% to 98% and for active metabolite is 95% to plasma protein. Volume of distribution is 100L.

Metabolized primarily in hepatic through CYP2C8 and CYP3A4

Excreted via urine 71%, and feces 14% Half-life elimination is 5.8 days and N- desmethyl enzalutamide is 7.8 to 8.6 days.




Blueberrypharma.com-img1

Medicine
Brand Enzamide
Ingredients Enzalutamide
Strength 40mg
Manufactured Intas
Rating

HOW Enzamide CAPSULE IS GIVEN

Enzamide dose recommended for the patient is 160mg which have been administer as four capsules of Enzamide 40mg. Enzamide 40mg is given orally and once in a day Enzamide 40mg can be taken with or without regard to food Swallow the whole capsule Do not dissolve, chew or open the capsules.

Over dosage

In overdose condition treatment with Enzamide 40mg solid be stop and provide supportive measures care and monitor the vital signs. Multiple dose If administer ≤ 240mg no seizures is reported but when taking 360mg,480mg, and 600mg daily then 3 seizures were absorbed. If overdose occur, the patient will have high risk of seizures.

More common

Back pain; bloating of the face, arms, hands, lower legs or feet; bloody urine; blurred vision; breathing difficulty; dizziness; loss of bowel control; nervousness.

Less common

anxiety; confusion or excitement; nightmares; span problems; itching skin; pale-colored urine.

Rare side effects

seizures

PRECAUTION AND WARNING

While receiving Enzamide drug the risk of seizure will develop in patients and by sudden loss of consciousness will leads harm to themselves. Inform the doctor If you have any symptoms of seizures.

If you had any neurological disorder like headache, lethargy, confusion and other visual with or without hypertension. Inform the doctor and he will discontinue the drug.

DRUG INTERACTION OF Enzamide CAPSULE

  • Enzamide Capsule interact with moderate to strong inducer of CYP3A4, CYP2C9 and CYP2C19 will cause High potential relevant drug interaction.
  • Enzamide capsule interact with inhibitors and inducers of CYP2C8 and CYP3A4 will cause Circulating concentration of enzalutamide.
  • Enzamide capsules interact with aromatase inhibitor sanastrozole reduce their effectiveness.

Contraindications


Enzamide is contraindicated in women during pregnancy it may cause fetal harm to death.



Enzamide capsule is unsafe to use during pregnancy because the drug may cause harm to the fetal and possibility loss of pregnancy. The drug Enzamide is not recommended for use in females. In lower dose itself when administrating to pregnant mice during organogenesis caused adverse reaction to the fetal than dose recommended in human dose.

No information regarding the presence of Enzamide in human milk, so using of this drug is unsafe for the breastfed infant

Store the drug at 20°C to 25°C. Keep the drug in dry place Keep the container closed tightly

If you missed a dose take it as soon as possible, before next dose time, then swap missed dose and continue regular schedule. Do not have 2 doses at a time. Take advice from the doctor.


Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.