Erlonat 100mg

Erlonat 100mg (Erlotinib), it is a hydrochloride salt of quinazoline derivative with anti-tumor activity. Erlonat 100mg exhibits its activity by binding to intracellular catalytic region of EGFR (epidermal growth factor receptor) tyrosine kinase Therefore signal transduction will be inhibited and leads to cell death

Erlotinib

Erlonat

100mg

Natco




Erlonat indicated for

Erlonat 100mg is primarily used for the treatment of; Advance or metastatic non small cell lung cancer

Pancreatic cancer by combining with gemcitabine. The mechanism of clinical action of erlotinib is not fully characterized, Erlotinib dose can be maximized upto 150mg.

How erlonat done its work

Erlonat 100mg involved in cell lysis by inhibiting the signal transduction of cancer cells through epidermal growth factor receptors, which are present on the surface of the cancer cells and also in normal cells.

Varoius erlotinib side effects as such as Hair weight, skin, Dermatitis, Diarrhea, Neuropathy, Anorexia, nail disorders, Conjunctivitis, Infection, disorders, pain, Loss of weight, Fatigue, Renal disorders, Bone pain, nausea, Anxiety, Cough, Vomiting, hepatic disorders, Abdominal pain, Paronychia, Keratoconjuctivities sicca, Pruritus, Dry Acne, Stomatits, Alopecia, ocular disorders.




Pharmacokinetic action of Erlonat

60% of drug absorbed after oral administration; the peak plasma concentration of the drug occurs within 4 hours The bioavailability of the drug 60% but increased by food to 100%

Nearly 93% of drug bound to the human plasma protein

Most of the drug metabolized in liver with the help of cytochrome isoenzymes like CYP3A4 to lesser extent CYP1A4

The elimination routes are feces and urine The half life is around 36 hours




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drug
Brand Erlonat
Ingredients Erlotinib
Strength 100mg
Manufactured Natco
Rating

Erlonat dosage and administration

The usual dose for adults in metastatic non small cell lung cancer; 150mg should be taken orally on an empty stomach as a single dose

Duration

At least 1 hour before or 2 hours after food The usual dose for adults in pancreatic cancer; 100mg should be taken orally as a single dose on empty stomach In this condition, Erlonat 100mg concomitant with gemcitabine

Limitations

Avoid concomitant with proton pump inhibitors Erlonat 100mg should be administered 10 hours after the H2 receptor antagonist and at least 2 hours before the next dose of H2 receptor antagonist

Cardiovascular

chest pain, peripheral edema

Central nervous system

fatigue, headache, dizziness, insomnia, paresthesia

Dermatologic

skin rash, Pruritus, paronychia, alopecia, acne, vulgaris

GIT

diarrhea, anorexia, nausea, loss of appetite, vomiting, stomatitis, abdominal pain

Genitourinary

urinary tract infection

Hematologic

anemia

Muscle

weakness, back pain, arthralgia, musculoskeletal pain

Ophthalmic

conjunctivitis, keratoconjuctivitis sicca

Pulmonary

cough, dyspnea

Miscellaneous

fever

Erlonat precaution in case of

Interstitial lung disease, Renal failure, Hepatotoxicity, Gastrointestinal perforation, Bullous and exfoliative skin disorders, Cerebrovascular accident, Ocular disorders, Hemorrhage, Embryo fetal toxicity


DRUG INTERACTION

Avoid these concomitants (combinations)

  • Aprepitant: increase the serum concentration of CYP3A4 substrates
  • Bosentan: depletes the serum concentration of CYP3A4 substrates
  • Ceritinib: increase the serum concentration of CYP3A4 substrates
  • Ciprofloxacin: elevate the serum concentration of Erlotinib
  • Conivaptan: increase the serum concentration of CYP3A4 substrates
  • CYP3A4 inducers (moderate or strong) decrease the serum concentration of Erlotinib and CYP3A4 inhibitors (moderate and strong) decrease the metabolism and increase the serum concentration respectively
  • Dabrafenib, dasatinib, deferasirox, Enzalutamide, proton pump inhibitors, H2 receptor antagonist etc




Erlonat Contraindicated to


Pregnancy and women who become pregnant

Breast feeding Hypersensitivity reaction



The pregnancy category of Tablet Erlonat 100mg comes under “D” Erlonat should not be recommended in pregnancy and lactation period. Erlonat 100mg cause harm to the unborn babies

The storage condition of Erlonat 100mg tablets container should be kept at 25°C (77°F); excursion between 15°C to 30°C Container should be keep away from moisture, heat and light

In case of missed dose, the patient should be advice by taking missed tablet within the period of next dose; otherwise the dose will be skipped and follow the regular dosing schedule Do not double the dose

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