Indivan

Indivan capsule is an inhibitor of human immunodeficiency protease. Indivan belongs to group of antiviral drugs that stops HIV from multiplication in our body Indivan is not required for HIV and Aids and it is prescription drug provided under the guidance of medical practioners.

Indinavir

Indivan

400mg

Cipla




Indications of Indivan

Indivan mainly used with combination of other antiretroviral to treat HIV infection. The drug uses are based on two clinical trials specifically for 1-year duration which defined as

1. Decrease in the risk of AIDS-defining illness or death
2. A prolonged excretion of HIV RNA.

Mechanism of action

An enzyme HIV-1 protease is required for the proteolytic gap of the viral polyprotein precursors integrate to the individual functional proteins form in HIV-1 infectious. Indinavir add to the protease active site and inhibits the activity of the enzyme. This barrierprohibitscleavage of the viral polyproteins causing in the formation of immature non-infectious viral particles.



Pharmacokinetic

Readily absorbed, duration of maximum plasma protein is 0.8±0.3 hrs.

Bounding of human plasma protein of Indivan is 60%

In hepatic is metabolized

< 20% of indinavir is eliminated in the urine unchanged. Half life of Indivan is 1.8 (±0.4) hours.



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Indivan
Brand Indivan
Ingredients Indinavir
Strength 400mg
Manufactured Cipla
Rating

How the drug administrated and dosage

The recommended dosage for adult is Indivan is 800mg administer as two 400mg capsules given orally every 8 hours in concomitant use with other antiretrovirals to treat HIV infections.

Indivan 800mg plus Ritonavir 100mg to 200mg twice a day The patients taking Indivan must be take intervals of 8 hours Indivan should give without food with water 1 hour before or 2 hours after meal.

It can be also taken with other liquids such as skim milk,juice,coffee or tea or with a light meal The patients ensure adequate hydration its prescribed adults drinks at least 1.5 liters of liquids during 24 hours

More common

Blood in urine, Just below ribs severe back pain

Less common

Abdominal pain, Chills, Loss of appetite, Dizziness, Fever, Headache, Unpleasant breath odor, Vomiting of blood

Rare cases

Confusion, Dehydration, Dry or itchy skin, Fruity mouth odor, Increased hunger, Increased urination, Pale skin, Troubled breathing with exertion, Unusual bleeding or bruising, Unusual tiredness or weakness, Vomiting, Weight loss

Warning and safety measures

Acute hemolytic anemia includes cases result in death. Hence stop the course of Indivan capsules The patient having hepatitis has been treated with Indivan will leads to hepatic failure and death.

Nephrolithiasis events cumulative frequency increase with increasing exposure of Indivan hence risk over time remains the same The pharmacological action and long-term consequence of these events are currently unknown. A causal relationship has not been established.

Drug- drug interaction

  • Interaction with drugs that induce CYP3A4 activity will increases the clearance of indinavir, reports in lowering of plasma concentrations of indinavir
  • Concomitant use of indinavir with drugs metabolized by CYP3A4 wills increases plasma concentration of the other drugs.

contraindications

Indivan contraindicated inInhibition of CYP3A4 and Hypersensitivity to any of its components



Pregnancy category is C There have no adequate and well controlled studies in pregnant women. It should be used when possible benefit clarifies the potential risk of the fetus.

The drug is unknown whether excreted in human milk, breast feeding mothers to be advice to stop if they receive Indivan

Stored in temperature at 15-30°C. Thecontainers should tightlyclosed. Dispense only in original container.

If patients missed a dose, then have the drug while you remember before next dose timing or skip the missed dose and follow regular schedule Please consult with the doctor

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