Intacept 25mg

Intacept 25mg is comes under the class of tumor necrosis factor prohibitor (TNF). Intacept 25mg is an anti-rheumatoid arthritis medicine, which produce its activity by depleting the TNF TNF is a protein which is originated from immune system protects the body from infections, in this condition immune system outgrowth repletion of TNF which will affect the normal healthy cells





Intacept 25mg involved in the treatment of

  • Ankylosing spondylitis
  • Rheumatoid arthritis
  • Juvenile idiopathic arthritis

Intacept 25mg is classified as

  • Disease modifying Anti-rheumatoid drug
  • Immunosuppressant
  • Tumor necrosis factor inhibitor

Indication of Intacept 25mg

The primary indication of Intacept 25mg is involved in the treatment of rheumatoid arthritis. Etanercept is either used alone or it may have combined with other medications like immunosuppressant methotrexate used to treat such conditions like rheumatoid, psoriatic, juvenile idiopathic & ankylosing spondylitis

How Intacept 25mg works in a body

Intacept works by prohibiting tumor necrosis factor, which is usually emerging cytokine requirement for inflammatory response, occurs in rheumatoid arthritis, juvenile idiopathic arthritis, AS etc.

Rheumatoid arthritis causes accumulation of tumor necrosis factor in synovial fluid causes joint destruction in RA, JIA, AS, PA, and PsO. Intacept inhibiting the binding of tumor necrosis factor with cell surface receptors like p55 & p75 and prohibition of activity occurs causes TNF biologically inactive

After administration of 25mg of Intacept subcutaneously, the peak plasma time occurs in 69 ± 34 hours. The absorption of Intacept occurs very slowly after administrating through subcutaneously. The outbreak of action occurs within 2 to 3 weeks, whereas in RA 1 to 2 weeks In RA the full effect of Intacept occurs in 3 months Clearance value of Intacept in both adults and pediatrics occurs as:

  • 46ml/hr/m2 in pediatric patients
  • 160 ± 80ml/hour in adults

The mean terminal half-life period of Intacept is Children with age ≥4 years & adults in JIA: 70 to 94.8 hours with the range of 31.2 to 104.8 hours. Adults with RA: 102 ± 30 hours

Intacept 25mg
Brand Intacept
Ingredients Etanercept
Strength 25mg
Manufactured Intas

Dosage and administration of Intacept 25mg

Intacept is administered as weekly dose. Intacept 50mg/1.0ml RA: rheumatoid arthritis; AS: Ankylosing spondylitis; PsA: psoriasis arthritis

In adults

Patients with rheumatoid arthritis, Ankylosing spondylitis& psoriasis arthritis: The recommended dosage of Intacept is 50mg once a week In patients with psoriasis arthritis: Initial dose: The recommended dosage of Intacept is 50mg should be taken as two times a week for 3 months Continuation therapy: The recommended dosage is 50mg given as once a week In these three conditions, methotrexate, salicylates, NSAIDS, or analgesics may be used with Intacept

In pediatrics

Juvenile idiopathic arthritis is one of the major condition that occur in the patients with age of 2years and older Based on the body weight, Intacept dosage can be calculated; 63kg or more: The recommended dosage is 50mg given weekly as a single dose Less than 63kg: The prescribed dosage is 0.8mg/kg weekly

Preparation of the Intacept 50mg

Intacept is prefilled syringes, containing 50mg vial/1.0ml. Intacept is a single use prefilled syringe, before administration it should be allowed to keep in a room temperature Do not take out the needle cover hence permits the syringe to reach room temperature To check the solution whether it is clear or not The content of the prefilled syringe should be checked before administration, if the content is between the two-purple fill level indicator lines, then the syringe should not use for administration

Intacept producing side effects

Viral, bacterial or fungal infections may occur Injection site pain, swelling, redness, Immunogenicity, Auto antibodies, Upper respiratory tract infections, Rash, Diarrhea, Pruritus, Pyrexia, Urticaria, Hypersensitivity reactions, Varicella infections in pediatric patient, Aseptic meningitis in pediatric patients with JIA

Post marketing experience:
Pancytopenia, Anemia, Leucopenia, Neutropenia, Thrombocytopenia, Lymphadenopathy, Aplastic anemia, Inflammatory bowel syndrome, Congestive heart failure, Elevation of transaminase, Angioedema, Chest pain, Autoimmune hepatitis, Lupus like syndrome, Interstitial lung disease

Intacept 25mg warning and safety measures

Intacept 25mg causes severe adverse effects; caution should be taken during the therapy

Serious infections:
In Intacept 25mg therapy, there is a chance of increase in exposure of severe infections caused by virus, bacteria and fungus. Concomitant use of Intacept 25mg with other Immuno suppressant agents like corticosteroids or methotrexate causes serious infection.

Patients should be counsel about the risk and exposure of adverse effects before starting the therapy; Whether patient may have suspected with tuberculosis or not Any fungal infections occur History of opportunistic infection

Various effects;
Neurological problems Malignancy like Lymphoma, leukemia, non-melanoma skin cancer In pediatric patients, chance to get lymphoma Severe congestive heart failure occurs Hepatitis B viral reactivation occurs Anaphylactic reactions occur Immunization, live vaccines are not used Autoimmunity, lupus like symptoms occur for this condition discontinue the treatment immediately

Immuno suppression Use of Intacept 25mg is not recommended in the patients who receiving Immuno suppressive agents for Wegener’s granulomatosis patients. Concurrent use of Intacept 25mg with anakinra or abatacept should be avoided to reduce the adverse effects of these drugs. Intacept 25mg injection is used cautiously in the patients having severe alcoholic hepatitis.

Intacept 25mg has interacts with some other drugs

In psoriasis arthritis patients who are receiving Intacept is efficient to rise effective B-cell immune responses to pneumococcal polysaccharide vaccine, but titers in accumulate moderately lower patients when compared to patients not getting vaccines Patients acquired Intacept should concurrently receive vaccines exception for live vaccines. Patients with serious hazard to varicella virus should discontinue Intacept therapy for that time

Immune modulating biologic products:
In active rheumatoid arthritis patients, Intacept & anakinra therapy should be followed for 24 weeks with concomitant use, as results patients may get serious effects compared to Etanercept used alone Common effects like bacterial pneumonia, cellulitis, pulmonary fibrosis, pneumonia due to respiratory failure Concomitant use of abatacept with Etanercept causes serious ill effects

Concurrent use of cyclophosphamide with Intacept should be avoided

While concomitant sulfasalazine with Etanercept causes depletion in neutrophils count

TGA pregnancy category: D US FDA pregnancy category: B The birth defects are higher in women who are receiving Intacept 25mg while compared to unexposed women In fetal and neonatal, the effect of Intacept 25mg is not known, but worse and welfare of Intacept 25mg is studied before administering live or live attenuated vaccines to infants

Breast feeding should not be recommended

Intacept 25mg injection 50mg & 25mg should be stored at 2°C to 8°C Protect from light Kept in cool and dry place

If patient fail to take the dose of Intacept 25mg , must consult with medical practitioner and administered the missed dose if possible. On the other way the missed dose should be avoid and follow the regular schedule.

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