Irinotraz 40mg is a chemotherapy medicine which inhibits the growth and spread of cancer cells in the body.
Irinotraz 40mg is required to treat cancers of the colon and rectum. It is commonly administering with other chemotherapy medicines in a combination chemotherapy.
Irinotraz 40mg is a prescription drugs which is used under supervision by medical physician



1ml in a vial


Irinotraz 40mg is mainly used for the treatment in patients with metastatic colon or rectal cancer.


Irinotecan is a cancer drug needed to treat many various types of cancer.
Irinotecan mechanism by inhibiting an enzyme, called topoisomerase I. Cells require this enzyme to multiply and grow. Irinotecan stops this enzyme, so the cancer cells can't replicate.


Peak Plasma Concentration of Irinotraz 40mg is 1660 ng/mL; SN-38 26.3 ng/mL

Irinotraz 40mg has Protein Bound: 30-68%; SN-38 95% and Vd: 110-234 L/m²

Irinotraz 40mg is mainly metabolized in hepatic, to SN-38; SN-38 is further metabolized by UGT1A1 and metabolites are metabolized to SN-38

Excretion of Irinotraz 40mg through urine, feces
Half-Life of Irinotraz: 6-12 hr; SN-38 10-20 hr


Ingredients Irinotecan
Strength 40mg
Pack 1ml in a vial


Colorectal cancer :
Monotherapy dosage :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 125mg/m2 IV infusion over 90 minutes on days 1,8,15,22, then 2 weeks off then repeat administrated weekly
Dose 2: 350mg/sq. meter IV Infusion over 30-90 minutes q3weeks administrated once every 3 weeks.
Combination therapy :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 180mg/m2 IV infusion over 30-90 minutes once on days 1,15, and 29, then followed by infusion with leucovorin and 5- fluorouracil; next cycle begins on day 43
Dose 2: 125mg/sq. meter on days 1,8,15 and 22 IV Infusion over 90 minutes then followed by bolus doses of leucovorin and 5-fluorouracil


Common side effects of Irinotraz 40mg :
Increased risk of getting an infection
Breathlessness and looking pale
Decrease appetite
Feeling sick
Hair loss
Mouth ulcers
Tummy pain.
Serious side effects of Irinotraz 40mg :
Liver changes
High blood pressure
Swelling around the drip site
Skin rash
Blood clots


When treatment will cause Hyperbilirubinemia, elderly, receiving radiation therapy, abdominal/pelvic radiation history
Not for use in concomitant with a regimen of 5-FU/LV administered for 4-5 consecutive days every 4 weeks outside of a clinical study
While on Irinotraz treatment interstitial pulmonary disease (IPD)-like events, contains fatalities, have been resulted (in combination and as monotherapy) for treatment of colorectal cancer and other advanced solid tumors
Risk of both early and late forms of diarrhea will occurs on treatment with Irinotraz


  • When Irinotraz 40mg interaction with 5-fluorouracil and leucovorin (LV), the disposition of irinotecan was not substantially altered.

  • Irinotraz 40mg Combination with strong CYP34A inducers do not administer unless there are no therapeutic alternatives

  • When Irinotraz 40mg combination with strong CYP34A inhibitors may increase systemic exposure to irinotecan or SN-38


Irinotraz 40mg contraindicated in patients with known hypersensitivity to the drug or its excipients

Pregnancy category is D
The drug Irinotraz 40mg may causes risk to fetus when administered to pregnant women. Advice the women about the potential hazard to the fetus

The drug Irinotraz 40mg has no data on the excretion into human milk. Advice the breastfeed mother potential risk to the infants. So, discontinue nursing when getting treatment with Irinotraz

Irinotraz 40mg is Store at 20°C to 25°C.
Protect from light
Keep in its original vial until the time of use

If dose is missed, then take the dose immediately before reach of next dose time or leave the missed dose and follow the normal schedule. Avoid have extra dose which leads to over dosage
Consult the doctor about missed dose and overdose

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