Irinotraz 40mg

Irinotraz 40mg is a chemotherapy medicine which inhibits the growth and spread of cancer cells in the body.
Irinotraz 40mg is required to treat cancers of the colon and rectum. It is commonly administering with other chemotherapy medicines in a combination chemotherapy.
Irinotraz 40mg is a prescription drugs which is used under supervision by medical physician

Irinotecan

Irinotraz

40mg

Alkem Laboratories Ltd




INDICATION

Irinotraz 40mg is mainly used for the treatment in patients with metastatic colon or rectal cancer.

MECHANISM

Irinotecan is a cancer drug needed to treat many various types of cancer.
Irinotecan mechanism by inhibiting an enzyme, called topoisomerase I. Cells require this enzyme to multiply and grow. Irinotecan stops this enzyme, so the cancer cells can't replicate.



Pharmacokinetic

Peak Plasma Concentration of Irinotraz 40mg is 1660 ng/mL; SN-38 26.3 ng/mL

Irinotraz 40mg has Protein Bound: 30-68%; SN-38 95% and Vd: 110-234 L/m²

Irinotraz 40mg is mainly metabolized in hepatic, to SN-38; SN-38 is further metabolized by UGT1A1 and metabolites are metabolized to SN-38

Excretion of Irinotraz 40mg through urine, feces
Half-Life of Irinotraz: 6-12 hr; SN-38 10-20 hr




Blueberrypharma.com-img1

drug
Brand Irinotraz
Ingredients Irinotecan
Strength 40mg
Manufactured Alkem Laboratories Ltd
Rating

DOSAGE AND ADMINISTRATION

Colorectal cancer :
Monotherapy dosage :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 125mg/m2 IV infusion over 90 minutes on days 1,8,15,22, then 2 weeks off then repeat administrated weekly
Dose 2: 350mg/sq. meter IV Infusion over 30-90 minutes q3weeks administrated once every 3 weeks.
Combination therapy :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 180mg/m2 IV infusion over 30-90 minutes once on days 1,15, and 29, then followed by infusion with leucovorin and 5- fluorouracil; next cycle begins on day 43
Dose 2: 125mg/sq. meter on days 1,8,15 and 22 IV Infusion over 90 minutes then followed by bolus doses of leucovorin and 5-fluorouracil

SIDE EFFECTS

Common side effects of Irinotraz 40mg :
Diarrhoea
Increased risk of getting an infection
Breathlessness and looking pale
Bruising
Tiredness
Decrease appetite
Feeling sick
Hair loss
Mouth ulcers
Tummy pain.
Serious side effects of Irinotraz 40mg :
Constipation
Liver changes
High blood pressure
Swelling around the drip site
Skin rash
Dizziness
Blood clots

PRECAUTIONS

When treatment will cause Hyperbilirubinemia, elderly, receiving radiation therapy, abdominal/pelvic radiation history
Not for use in concomitant with a regimen of 5-FU/LV administered for 4-5 consecutive days every 4 weeks outside of a clinical study
While on Irinotraz treatment interstitial pulmonary disease (IPD)-like events, contains fatalities, have been resulted (in combination and as monotherapy) for treatment of colorectal cancer and other advanced solid tumors
Risk of both early and late forms of diarrhea will occurs on treatment with Irinotraz

DRUG – DRUG INTERACTION

  • When Irinotraz 40mg interaction with 5-fluorouracil and leucovorin (LV), the disposition of irinotecan was not substantially altered.

  • Irinotraz 40mg Combination with strong CYP34A inducers do not administer unless there are no therapeutic alternatives

  • When Irinotraz 40mg combination with strong CYP34A inhibitors may increase systemic exposure to irinotecan or SN-38

Contraindications


Irinotraz 40mg contraindicated in patients with known hypersensitivity to the drug or its excipients



Pregnancy category is D
The drug Irinotraz 40mg may causes risk to fetus when administered to pregnant women. Advice the women about the potential hazard to the fetus

The drug Irinotraz 40mg has no data on the excretion into human milk. Advice the breastfeed mother potential risk to the infants. So, discontinue nursing when getting treatment with Irinotraz

Irinotraz 40mg is Store at 20°C to 25°C.
Protect from light
Keep in its original vial until the time of use

If dose is missed, then take the dose immediately before reach of next dose time or leave the missed dose and follow the normal schedule. Avoid have extra dose which leads to over dosage
Consult the doctor about missed dose and overdose

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.