Kisqali 200mg

Kisqali 200mg is indicated in combination with letrozole which an aromatase inhibitor for the treatment for women with breast cancer.

Ribociclib

Kisqali

200mg

Novartis




Description

Kisqali 200mg belongs to selective cyclin-dependent kinase inhibitor, a class of drugs which help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can allow cancer cells to develop and divide too fastly. Aiming CDK4/6 with improve precision may play a role in providing that cancer cells do not continue to multiply uncontrollably.

Mechanism of action

Ribociclib is a type of drug which can be needed along with an aromatase inhibitor to cure women with advanced hormone receptor-positive breast cancer. Ribociclib belongs to small molecule cyclin-dependent kinase (CDK) inhibitor. The drug stops proteins in the cell called cyclin-dependent kinase (CDK) 4 and CDK 6. In hormone positive breast cancer cells, inhibiting these proteins helps to block the cells from segregate to make new cells. It helps inhibit the cells from moving from G1 to S cell cycle phase in the division process. This reduce cancer growth. The Co administration of Ribociclib and an aromatase inhibitor (e.g. letrozole) is more active compared with each agent alone.



Pharmacokinetic

Time to maximum plasma concentration is 1-4 hr and steady state achieved is 8 days

Human plasma protein bound is 70%

Mainly metabolised by hepatic through CYP3A4 in humans.

Kisqali is eliminated through feces 69% and urine 23% Half -life is 32.6 hours



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drug
Brand Kisqali
Ingredients Ribociclib
Strength 200mg
Manufactured Novartis
Rating

The prescribed dose of Kisqali is 600mg (three 200mg film coated tablets) administrated orally once daily for 21 consecutive days followed by 7 days off therapy resulting in a complete cycle of 28 days The drug Kisqali can be administrated with or without food. Overdose: overdose with Kisqali in human has experienced very limited. In case occurs provide general symptomatic and supportive measures.

Side effects

• Decreased in blood counts
• Nausea and vomiting
• Increased liver enzymes
• Fatigue
• Diarrhea
• Hair loss
• Decreased kidney function
• Lack of appetite
• Rash
• Fever
• Itching
• Insomnia
• Urinary tract infection.

Precautions

Kisqali has been exposed to prolong the QT interval in a concentration-dependent manner. Based on the observed QT prolongation during therapy, Kisqali may needed dose interruption, reduction, or discontinuation. Avoid the combination use with tamoxifen due to increased QT prolongation. In patients with advanced or metastatic breast cancer will increases in transaminases were resulted; perform liver function test before starting treatment with Kisqali; based on severity of the transaminase elevations, Kisqali may require dose interference, reduction or stopping.

DRUG – DRUG INTERACTION

  • Kisqali 200mg co administration with strong CYP3A4 inhibitor will increased Ribociclib exposure in healthy subjects but this combination cannot be avoided, so reduce the dose of Kisqali to 400mg once daily
  • Kisqali 200mg co administration with strong CYP3A4 inducers will decreased Ribociclib exposure in healthy subjects by 89%
  • Concomitant use of midazolam with multiple doses of Kisqali will increased the midazolam exposure by 3.8-fold in healthy subjects.

Contraindications

None.




There are no studies with the use of Kisqali 200mg in pregnant women to inform drug-associated risks. Hence avoid becoming pregnancy during Kisqali 200mg treatment

Erleada is not indicated for female patients

The drug Kisqali is store at 20°C to 25°C.

If dose is missed the have the dose immediately before next dose timing reaches or skip the missed dose and continue the regular schedule. Consult doctors regarding missed dose.


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