Lenalid 15mg

Lenalid 15mg contains Lenalidomide as an active substance which belongs to thalidomide analogue. Lenalid 15mg contains some pharmacological activities like immuno modulatory, anti-neoplastic, & anti-angiogenesis. Lenalid 15mg is a prescription medicine; used under the supervision of medical oncologist. Lenalid 15mg is used by combining with dexamethasone.

Lenalidomide

Lenalid

15mg

Natco




Lenalid indication

The most common indications of Lenalid 15mg are; Multiple myeloma: Lenalid 15mg should be used in combination with dexamethasone.

Myelodysplastic syndrome: Lenalid 15mg is used to treat this condition Mantle cell lymphoma: Lenalid 15mg is used for this condition, if patients are not responding to the Bortezomib treatment.

Lenalid mechanism

Lenalid includes in the restraint of tumor rot factor alpha arrangement, which support the T-cells and causes lessening serum levels of cytokines vascular endothelial development factor and fundamental fibroblast development factor.

Lenalid is additionally engaged with the preclusion of angiogenesis. Lenalidomide is additionally empowered G1 cell cycle capture and apoptosis of ruinous cells.


Lenalid 15mg
Brand Lenalid
Ingredients Lenalidomide
Strength 15mg
Manufactured Natco
Rating

Lenalid dosage & administration

The usual prescribed dose of Lenalidomide in myelodysplastic syndromes is 10mg should be given as once a day.

For renal damaged patients;
In Patients with CrCl>60ml/min should not require dosage adjustment of Lenalidomide.
In Patients with CrCl 30 to 60ml/min, 15mg of Lenalidomideshould be given orally as once a day.
In Patient with CrCl <30ml/min, 2.15mg of Lenalidomideshould be administered orally as a once a day.

Dosage variation

Thrombocytopenia

Drops to <50000/mcL, therapy should be interrupted. Back to > or equal to 50000/mcL, continue the Lenalidomideof 15mg/day.

Neutropenia

Drops to <500/mcL, therapy should be postponed. Back to > or equal to 500/mcL, treatment should be continue to 15mg/day.

Multiple myeloma

In this condition, Lenalidomideis concomitant with dexamethasone. The usual dose of Lenalidomideis 215mg should be administered as once daily on day 1 to 21. The dose of dexamethasone; 40mg of dexamethasone should be followed on day 1 to 4, 9 to 12 & 17 to 20 of each 28 day cycles. Patient with >75 years, 20mg of dexamethasone should be recommended on day 1, 8, 15, & 22.

Mantle cell lymphoma

The advised dose of Lenalidomidefor this condition is 215mg should be administered orally as once daily.

For renal damaged patients
Patient with CrCl 30 to 60ml/min, 10mg of Lenalidomideshould be administered as once daily.
Patient with CrCl<30ml/min, 115mg of Lenalidomideshould be used for q48hr.

Pediatrics
The potency & effectiveness of Lenalidomide has not been evaluated in pediatric patients with age of <18 years.

Lenalid 15mg side effects

Second primary malignancies, Liver toxicity, Hypersensitivity reactions, Tumor lysis syndrome, Tumor flare reactions, Thyroid disorders, Fetal toxicity, Hematological toxicity, Elevation of mortality rate

Common side effects

Fatigue, Asthenia, Pyrexia, Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Muscle weakness, pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout

Lenalid 15mg warning

The most common life threatening condition like: Embryo fetal damage, Hypersensitivity reactions, Venous & arterial thromboembolism, Blood clotting effects, Hematological disorders, For all these conditions, some supportive measures should be used and provide safety measures.

DRUG INTERACTION

  • Lenalid 15mg interaction with digoxin, causes increased concentration of digoxin causes increased risk of adverse effects related to digoxin.
  • Lenalid 15mg interaction with Erythropoietic agents, leads to produced increased risk of thrombosis. Counsel the patients before starting this combination treatment.
  • Lenalid 15mg interaction with warfarin, causes increased exposure of bleeding disorders. Monitor the INR value & prothrombin time.

Contraindications


Lenalid 15mg should be contraindicated to pregnancy period. Hypersensitivity reactions are produced due to patients are contraindicated to the Lenalid 15mg component.



Lenalid 15mg uses in


Pregnancy category X Lenalid 15mg causes fetal damage leads to death Breast feeding should not be allowed

Lenalid 15mg capsules should be stored at 20°C to 25°C Protect the container from light Keep away from moisture & heat.

The missed dose of Lenalid 15mg should be avoided. If missed dose occurs, then patients should be consulting with medical oncologist Maintain the regular dosing schedule. Over dosage of Lenalid 15mg leads to neutropenia & thrombocytopenia as most common adverse effects. Provide general supportive therapy. Monitor the blood cells counts frequently during the treatment.


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