Lenalid 5mg contains Lenalidomide as an active substance which belongs to thalidomide analogue. Lenalid 5mg contains some pharmacological activities like immuno modulatory, anti-neoplastic, & anti-angiogenesis. Lenalid 5mg is a prescription medicine; used under the supervision of medical oncologist. Lenalid 5mg is used by combining with dexamethasone.
The most common indications of Lenalid 5mg are;
Multiple myeloma: Lenalid 5mg should be used in combination with dexamethasone.
Myelodysplastic syndrome: Lenalid 5mg is used to treat this condition Mantle cell lymphoma: Lenalid 5mg is used for this condition, if patients are not responding to the Bortezomib treatment.
Lenalid includes in the restraint of tumor rot factor alpha arrangement, which support the T-cells and causes lessening serum levels of cytokines vascular endothelial development factor and fundamental fibroblast development factor.
Lenalid is additionally engaged with the preclusion of angiogenesis. Lenalidomide is additionally empowered G1 cell cycle capture and apoptosis of ruinous cells.
Lenalid dosage & administration
The usual prescribed dose of Lenalidomide in myelodysplastic syndromes is 10mg should be given as once a day.
For renal damaged patients;
In Patients with CrCl>60ml/min should not require dosage adjustment of Lenalidomide.
In Patients with CrCl 30 to 60ml/min, 5mg of Lenalidomideshould be given orally as once a day.
In Patient with CrCl <30ml/min, 2.5mg of Lenalidomideshould be administered orally as a once a day.
Drops to <50000/mcL, therapy should be interrupted. Back to > or equal to 50000/mcL, continue the Lenalidomideof 5mg/day.
Drops to <500/mcL, therapy should be postponed. Back to > or equal to 500/mcL, treatment should be continue to 5mg/day.
In this condition, Lenalidomideis concomitant with dexamethasone. The usual dose of Lenalidomideis 25mg should be administered as once daily on day 1 to 21. The dose of dexamethasone; 40mg of dexamethasone should be followed on day 1 to 4, 9 to 12 & 17 to 20 of each 28 day cycles. Patient with >75 years, 20mg of dexamethasone should be recommended on day 1, 8, 15, & 22.
Mantle cell lymphoma
The advised dose of Lenalidomidefor this condition is 25mg should be administered orally as once daily.
For renal damaged patients
Patient with CrCl 30 to 60ml/min, 10mg of Lenalidomideshould be administered as once daily.
Patient with CrCl<30ml/min, 15mg of Lenalidomideshould be used for q48hr.
The potency & effectiveness of Lenalidomide has not been evaluated in pediatric patients with age of <18 years.
Lenalid 5mg side effects
Second primary malignancies, Liver toxicity, Hypersensitivity reactions, Tumor lysis syndrome, Tumor flare reactions, Thyroid disorders, Fetal toxicity, Hematological toxicity, Elevation of mortality rate
Common side effects
Fatigue, Asthenia, Pyrexia, Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Muscle weakness, pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout
Lenalid 5mg warning
The most common life threatening condition like: Embryo fetal damage, Hypersensitivity reactions, Venous & arterial thromboembolism, Blood clotting effects, Hematological disorders, For all these conditions, some supportive measures should be used and provide safety measures.