LENANGIO 10MG

Lenangio 10mg contains Lenalidomide as an active substance which belongs to thalidomide analogue. Lenangio 10mg contains some pharmacological activities like immuno modulatory, anti-neoplastic, & anti-angiogenesis. Lenangio 10mg is a prescription medicine; used under the supervision of medical oncologist. Lenangio 10mg is used by combining with dexamethasone.

Lenalidomide

Lenangio

10mg

Dr. Reddy’s




Lenangio indication

The most common indications of Lenangio 10mg are;
Multiple myeloma: Lenangio 10mg should be used in combination with dexamethasone.
Myelodysplastic syndrome: Lenangio 10mg is used to treat this condition
Mantle cell lymphoma: Lenangio 10mg is used for this condition, if patients are not responding to the Bortezomib treatment.

Lenangio mechanism

Lenangio includes in the restraint of tumor rot factor alpha arrangement, which support the T-cells and causes lessening serum levels of cytokines vascular endothelial development factor and fundamental fibroblast development factor.
Lenangio is additionally engaged with the preclusion of angiogenesis.
Lenalidomide is additionally empowered G1 cell cycle capture and apoptosis of ruinous cells.


drug
Brand Lenangio
Ingredients Lenalidomide
Strength 10mg
Manufactured Dr. Reddy’s Laboratories
Rating

Lenangio Dosage & administration

The usual prescribed dose of Lenalidomide in myelodysplastic syndromes is 10mg should be given as once a day. For renal damaged patients; In Patients with CrCl >60ml/min should not require dosage adjustment of Lenalidomide.
In Patients with CrCl 30 to 60ml/min, 5mg of Lenalidomide should be given orally as once a day.
In Patient with CrCl <30ml/min, 2.5mg of Lenalidomide should be administered orally as a once a day.

Dosage variation

Thrombocytopenia

Drops to <500/mcL, therapy should be postponed.
Back to > or equal to 500/mcL, treatment should be continuing to 5mg/day.

Neutropenia

Drops to <500/mcL, therapy should be postponed.
Back to > or equal to 500/mcL, treatment should be continuing to 5mg/day.

Multiple myeloma

In this condition, Lenalidomide is concomitant with dexamethasone.
The usual dose of Lenalidomide is 25mg should be administered as once daily on day 1 to 21.
The dose of dexamethasone;
40mg of dexamethasone should be followed on day 1 to 4, 9 to 12 & 17 to 20 of each 28-day cycles.
Patient with >75 years, 20mg of dexamethasone should be recommended on day 1, 8, 15, & 22.

Mantle cell lymphoma

The advised dose of Lenalidomide for this condition is 25mg should be administered orally as once daily.
For renal damaged patients:
Patient with CrCl 30 to 60ml/min, 10mg of Lenalidomide should be administered as once daily.
Patient with CrCl <30ml/min, 15mg of Lenalidomide should be used for q48hr.
Pediatrics:
The potency & effectiveness of Lenalidomide has not been evaluated in pediatric patients with age of <18 years.

Lenangio side effects

Second primary malignancies, Liver toxicity, Hypersensitivity reactions, Tumor lysis syndrome, Tumor flare reactions, Thyroid disorders, Fetal toxicity, Hematological toxicity, Elevation of mortality rate

Common side effects

Fatigue, Asthenia, Pyrexia, Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Muscle weakness, pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout

Lenangio warning

The most common life-threatening condition like : Embryo fetal damage
Hypersensitivity reactions
Venous & arterial thromboembolism
Blood clotting effects
Hematological disorders
For all these conditions, some supportive measures should be used and provide safety measures.

DRUG INTERACTION

  • Lenangio 10mg interaction with digoxin, causes increased concentration of digoxin causes increased risk of adverse effects related to digoxin.
  • Lenangio 10mg interaction with Erythropoietic agents, leads to produced increased risk of thrombosis. Counsel the patients before starting this combination treatment.
  • Lenangio 10mg interaction with warfarin, causes increased exposure of bleeding disorders. Monitor the INR value & prothrombin time.

Contraindications


Lenangio 10mg should be contraindicated to pregnancy period. Hypersensitivity reactions are produced due to patients are contraindicated to the Lenangio 10mg component.



Lenangio 10mg uses in


Pregnancy category X Lenangio 10mg causes fetal damage leads to death. Breast feeding should not be allowed

Lenangio 10mg capsules should be stored at 20°C to 25°C Protect the container from light Keep away from moisture & heat.

The missed dose of Lenangio 10mg should be avoided. If missed dose occurs, then patients should be consulting with medical oncologist Maintain the regular dosing schedule. Over dosage of Lenangio 10mg leads to neutropenia & thrombocytopenia as most common adverse effects. Provide general supportive therapy. Monitor the blood cells counts frequently during the treatment.


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