Lenvatinib 10mg

Lenvatinib 10mg is a type of targeted therapy which aim the specific cancer cells therefore reduces side effects caused by affected cells.
Lenvatinib 10mg is a multi-kinase inhibitor and antineoplastic agents
Lenvatinib 10mg interfering with a protein which promotes cell division by preventing the cancer cell growth.

Lenvatinib

Lenvatinib

10 mg

Eisai Co. Ltd




Indication

Lenvatinib 10mg is a type of targeted therapy which aim the specific cancer cells therefore reduces side effects caused by affected cells.
Lenvatinib 10mg is a multi-kinase inhibitor and antineoplastic agents
Lenvatinib 10mg interfering with a protein which promotes cell division by preventing the cancer cell growth.

Mechanism of action

Lenvatinib is an inhibitor of RTK (receptor tyrosine kinase) that interfere with the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4).
Lenvatinib also blocks other RTKs which have been suspected in pathogenic angiogenesis, growth of tumor, and cancer breakthrough in addition to their normal cellular activity, involves the fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet imitative growth factor receptor alpha (PDGFRα), KIT, and RET.



Pharmacokinetics

duration of peak plasma concentration is 1 to 4 hours post dose. Effect with food is low to the extent Lenvatinib of absorption.

Lenvatinib binding to human plasma proteins is 98% to 99%.

Lenvatinib 10mg is mainly metabolized in CYP3A. Lenvatinib 10mg metabolic pathway is identified as enzymatic and non-enzymatic processes.

Excreted via 64% feces and 25% urine.


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drug
Brand Lenvatinib
Ingredients Lenvatinib
Strength 10mg
Manufactured Eisai Co Ltd
Rating

The prescribed dose of Lenvatinib for the adult patients is 24mg and administer has two 10mg capsules and one 4mg capsule given orally, once daily taken with or without food.
The Lenvatinib tablet should continue until disease progression or until unacceptable toxicity occurs.
Take Lenvatinib tablet at the same time.
Patients with severe renal or hepatic impairment the dose is 14mg administer once daily orally.
OVERDOSE: Lenvatinib is not expected to be dialyzable because of high plasma protein binding and if the dose receiving of Lenvatinib 10mg orally then causes death due to multiorgan dysfunction occurred in the patients.

Common side effects :
Tiredness
Peeling of skin on palms and sole of the feet
Constipation
Loss of appetite
Weight loss
Joint and muscle pain
Insomnia
Serious side effects :
Shortness of breath
Chest pain
Pain in arm, back, neck or jaw
Seizures
Black, tarry or bloody stools
Heavy menstrual bleeding
Coughing up blood
Yellowing of the skin or eyes

Precaution

Hypertension :
Blood pressure may rises while treatment with Lenvatinib 10mg. Your doctor will preferably check your blood pressure during your treatment.
Allergic reaction :
Inform the doctor if you are allergic to Lenvatinib 10mg, any other regimens, or any of the ingredients in Lenvatinib 10mg capsules.
other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may to change the doses of your drugs or guide carefully for adverse reaction.
OT interval Prolongation :
Inform doctor if you have or had seizures, hypertension, a stroke, a heart attack, , especially those due to blood clots, a fistula, a tear in the wall of your GIT, QT interval prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), low levels of Ca,K or Mg in your blood, bleeding problems, or cardiac, renal, or hepatic disease.
Embryofetal Toxicity :
Take into the knowledge that Lenvatinib 10mg may reduce the fertility in men and women. It not means that you or your partner cannot become pregnant. Inform doctor before if you are pregnant or plan to become pregnant. After becoming pregnant, you should use birth control while treatment with Lenvatinib 10mg and for at least 2 weeks after your treatment, become pregnant during Lenvatinib therapy, call your doctor immediately.
Lenvatinib 10mg may harm the fetus.
Inform the doctor if you are breastfeeding or plan to breastfeed. Avoid breastfeed during Lenvatinib 10mg treatment.

DRUG INTERACTION

  • Lenvatinib 10mg Concomitant use with Carboplatin, paclitaxel has no specific pharmacokinetics impact

  • Combination with CYP3A, Pglycoprotein (P-gp) inhibitors and inducers has no dose adjustment for Lenvatinib 10mg.

Missed Dose

If patients fail to administer the dose of drug and should be take within the time and cannot be taken within 12 hours, otherwise the missed dose should be skipped and follow the next dosing schedule. Please consult with the doctor.



When administrated to pregnant, Lenvatinib 10mg drugs can cause harm to the fetal. There are no available human data related to drug associated risk. Advice pregnant women specific risk to fetus.

It’s not known that drug is present in human milk. Excretion in human milk is unknown. Because of the serious side effects in infants from the drug, advice to avoid breast feeding during treatment with Lenvatinib 10mg.

Store at 25°C
Lenvatinib 10mg is supplied in cartoons cards
Keep out of the children hands
Discard the after-expiry date.

In case of missed dose, patients must consult with medical practitioner and follow the instructions given by them.
thereby missed dose should be avoid and follow the regular dosing schedule

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