Leuben 100mg

Leuben belongs to group of parenterally administered alkylating agent needed alone and in concomitant with other antineoplastic agents in the therapy of chronic lymphocytic leukaemia and refractory forms of non-Hodgkin lymphoma.
Leuben is a prescription drug which is used under the guidance of medical supervision

Bendamustine

Leuben

100mg

Hetero




Indication

Leuben 100mg is indicated for the treatment of following condition;
Chronic lymphocytic Leukaemia
Indolent B-cell non-Hodgkin’s lymphoma

Mechanism of action

Bendamustine is type of alkylating agent. These agents are more active in the resting phase of the cell-cycle. There are various types of alkylating agents.
Bendamustine belongs to nitrogen mustard derivative and is active against resting as well as multiplying cells.



Pharmacokinetics

Time to peak plasma: At end of infusion

Protein bound: 94-96%
Volume of distribution: 25L

Metabolized by CYP1A2

Excretion: feces 90%; Urine 1-10%
Half-life: 40min


Blueberrypharma.com-img1

drug
Brand Leuben
Ingredients Bendamustine
Strength 100mg
Manufactured Hetero Pharmaceuticals
Rating

For chronic lymphocytic Leukaemia :
The recommended dose is 100mg/m2 IV infusion on days 1 and 2 of 28-day cycle, repeated for up to 6 cycles
Non-Hodgkin Lymphoma :
The recommended dose is 120mg/m2 IV infusion on days 1 and 2 of 21-day cycle repeated for upto 8 cycles

Side effects caused due to Leuben 100mg :
Decreased blood counts
Infusion reaction
Fever
Nausea
Vomiting
Fatigue
Diarrhae
Rash
Infertility.

Precautions

Discontinue, if patients experience severe infusion reactions
While on treatment will causes Mild-mod renal impairment, mild hepatic impairment
Probably of anaphylactic/infusion reactions: serious in rare cases
Myelosuppression may report; decrease dose; restart treatment based on ANC and platelet count recovery; difficult situation of myelosuppression may lead to death
Check further fever and other signs of infection and treat promptly

DRUG INTERACTION

  • Leuben interaction with CYP1A2 inhibitors will have possible to increase plasma concentration of bendamustine and decrease plasma concentration of active metabolites.

  • Leuben interaction with CYP1A2 inducers will have possible to decrease plasma concentration of bendamustine and increase plasma concentration of active metabolites.

Contraindication

Leuben is contraindicated in patients having known hypersensitivity to bendamustine and its metabolites



Pregnancy category is D
Based on adverse reaction, there is a positive symptom of human fetal risk
Avoid using Leuben during pregnancy

The drug excreted into human milk is unknown and effects in the new born baby are unknown
Hence use is contraindicated

store in refrigerator at 2°C to 8°C
keep in original containers until time of use

If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information.

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.