Leuben 100mg

Leuben belongs to group of parenterally administered alkylating agent needed alone and in concomitant with other antineoplastic agents in the therapy of chronic lymphocytic leukaemia and refractory forms of non-Hodgkin lymphoma.
Leuben is a prescription drug which is used under the guidance of medical supervision






Leuben 100mg is indicated for the treatment of following condition;
Chronic lymphocytic Leukaemia
Indolent B-cell non-Hodgkin’s lymphoma

Mechanism of action

Bendamustine is type of alkylating agent. These agents are more active in the resting phase of the cell-cycle. There are various types of alkylating agents.
Bendamustine belongs to nitrogen mustard derivative and is active against resting as well as multiplying cells.


Time to peak plasma: At end of infusion

Protein bound: 94-96%
Volume of distribution: 25L

Metabolized by CYP1A2

Excretion: feces 90%; Urine 1-10%
Half-life: 40min


Brand Leuben
Ingredients Bendamustine
Strength 100mg
Manufactured Hetero Pharmaceuticals

For chronic lymphocytic Leukaemia :
The recommended dose is 100mg/m2 IV infusion on days 1 and 2 of 28-day cycle, repeated for up to 6 cycles
Non-Hodgkin Lymphoma :
The recommended dose is 120mg/m2 IV infusion on days 1 and 2 of 21-day cycle repeated for upto 8 cycles

Side effects caused due to Leuben 100mg :
Decreased blood counts
Infusion reaction


Discontinue, if patients experience severe infusion reactions
While on treatment will causes Mild-mod renal impairment, mild hepatic impairment
Probably of anaphylactic/infusion reactions: serious in rare cases
Myelosuppression may report; decrease dose; restart treatment based on ANC and platelet count recovery; difficult situation of myelosuppression may lead to death
Check further fever and other signs of infection and treat promptly


  • Leuben interaction with CYP1A2 inhibitors will have possible to increase plasma concentration of bendamustine and decrease plasma concentration of active metabolites.

  • Leuben interaction with CYP1A2 inducers will have possible to decrease plasma concentration of bendamustine and increase plasma concentration of active metabolites.


Leuben is contraindicated in patients having known hypersensitivity to bendamustine and its metabolites

Pregnancy category is D
Based on adverse reaction, there is a positive symptom of human fetal risk
Avoid using Leuben during pregnancy

The drug excreted into human milk is unknown and effects in the new born baby are unknown
Hence use is contraindicated

store in refrigerator at 2°C to 8°C
keep in original containers until time of use

If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information.


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