Myezom 2mg

Myezom 2mg belongs to anti-cancer medicine, which is available in the form of lyophilized powder Myezom 2mg is a first beneficial proteasome inhibitor; proteasome is a cellular structure that breaks the proteins

Bortezomib

Myezom

2mg

Dr. Reddy’s






Indication

Myezom 2mg is majorly used to treat
• Multiple myeloma
• Mantle cell lymphoma

Myezom 2mg mechanism of action

Bortezomib is a kind of cancer treatment drug called a proteasome inhibitor. In cells, Proteasomes are present. They need to break down proteins that the cell doesn't need. Bortezomib stops the proteasomes so the proteins build up inside the cell. The cell then dies. The functioning site of proteasome has Chymotrypsin like, Trypsin like, Post glutamyl peptide hydrolysis activity.

The 26S proteasome enzyme diminish assorted proteins which demanding to cancer cells survival like cyclins, tumor suppressors, BCL-2 & cyclin dependent kinase inhibitors Prohibition of these degenerations, sensitizes cells to apoptosis and cell arrest



Pharmacokinetic

The peak plasma level of Myezom 2mg occurs as 509ng/ml

The human plasma protein binding of Myezom 2mg occurs as nearly 83%

Major metabolic pathway: deboronation to form 2-deboronated metabolites which are inactive as 26S proteasome inhibitors Myezom 2mg is metabolized hepatically with the help of cytochrome P 450 enzymes 3A4, 2C19, & 1A2 by oxidation

The single dose IV: The half-life period occurs at 9 to 15 hours; Multiple 1mg/m2 dosing: 40 to 193 hours Multiple 1.3mg/m2 dosing: 76 to 108 hours




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Myezom 2mg
Brand Myezom
Ingredients Bortezomib
Strength 2mg
Manufactured Dr. Reddy’s
Rating

Myezom 2mg dosage and administration

Generally, Myezom is in lyophilized powder form; which is reconstituted by using 0.9% sodium chloride (NS) Myezom3.5mg should be reconstituted in 3.5ml NS The route of administration is IV bolus Intrathecal not use for administration

In adults

Mantle cell lymphoma

The usual dose of Myezom for untreated mantle cell lymphoma is;
1.3mg/m2 of Myezom administered as IV bolus given as two times weekly by combining with rituximab, cyclophospahmide, doxorubicin and tablet prednisolone for two weeks (day I, IV, VIII & XI) followed by 10 day rest period (day II through 21)

In Relapse stage:
The recommended dose is 1.3mg/m2 administered as IV bolus or subcutaneous two times for two weeks (day I, IV, VIII & XI) followed by 10-day rest period (day II through 21) The treatment continued for above 8 cycles may be taken for once weekly for 4 weeks (day 1, 8, 15 & 22), followed by 13-day rest (days 23 through 35)

Multiple myeloma

In the therapy of previously untreated multiple myeloma: 1.3mg/m2 of dose should be administered as 3 to 5 seconds through IV bolus or subcutaneous by combining with tablet melphalan and prednisolone for nine 6 weeks therapy cycles Cycles 1 over 4, is taken for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) Cycles 5 over 9, is taken once a week (day 1, 8, 22, and 29)

Key points

Partially, 72 hours should be passing between following doses of Myezom

In Relapse stage

The recommended dose of Myezom is 1.3mg/m2 should be administered through IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) followed by a ten-day rest course (day 12 through 21) Treatment schedule increased above 8 cycles may be taken once weekly for 4 weeks (day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)

Important points

Myezom should be used alone or combination with dexamethasone Three-week course is considered as therapy cycle A minimum 72 hours should slip away between constant doses of Myezom

Most common side effects occurred after administration of Myezom 2mg includes

Black tarry stools Bleeding gums Blood in urine Blurred vision Body aches Burning, crawling, itching, numbness, prickling Chest pain Cough producing mucus, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, ear congestion, loss of voice

Less common side effects

Dilated veins, discomfort, increased sensitivity of pain & touch, irregular breathing, heart beats, swelling of peripheral organs, thickening of bronchial secretions Belching, bone pain, difficulty with moving & bowel movements, cold and shivering, loss of appetite, loss of taste, muscle cramps, muscle pain, stomach discomfort. Vomiting, loss of weight

While taking Myezom 2mg some adverse effects occurs care should be taken in the conditions like

Myezom 2mg leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, neuropathic pain Manage postural Hypotension by altering the antihypertensive agents, hydration, and administration of mineralocorticoids or sympathomimetics Cardiac toxicity Pulmonary toxicity like Acute Respiratory Distress Syndrome, pneumonitis, interstitial pneumonia, lung infiltration

Posterior reversible encephalopathy syndrome-stop the Myezom 2mg therapy Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity

Myezom drug interaction

  • Strong CYP3A4 inhibitors: there is a chance of getting Myezom toxicity; so to reduce the dose of Myezom while concomitant with CYP3A4 inhibitors
  • Strong CYP3A4 inducers: decrease the exposure of Myezom
  • Avoid concomitant with St. John’s wort to decrease the exposure of Myezom
  • No clinical effect on Myezom exposure while concomitant with melphalan-prednisone or dexamethasone alone

Myezom 2mg CONTRAINDICATION


Hypersensitivity reaction occurs in patients who are contraindicated to Myezom 2mg , boron, boric acid or glycine.

Myezom 2mg is given through IV bolus or subcutaneous; whereas intrathecal administration is contraindicated to the patients who are receiving Myezom 2mg



Myezom 2mg is not recommended in pregnancy condition, it causes harm to fetus Breast feeding is not recommended

Myezom 2mg vial should be stored at 20°C to 25°C (68°F to 77°F); excursion between 15°C to 30°C (59°F to 86°F) Keep away from light and heat

Myezom 2mg is not a normal medicine used as anti-cancer drug; it is not to be self-medicated If patient fail to take the dose of Myezom 2mg, must consult with medical oncologist and followed the dosing schedules Do not self administered Follow the advice given by physician and do not missed the cycles for course of therapy

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