Myhep all

Myhep all is an anti-hepatitis C viral medicine, containing active components known as Sofosbuvir and Velpatasvir available in the strength of 400mg & 100mg respectively. Velpatasvir is a class of anti-hepatitis C viral drug, called NS5A multiplication complex inhibitors. This may have combined with other anti-viral agent Sofosbuvir which expels its work by stopping the virus which may causes hepatitis C viral infection from spreading inside the body. Myhep all tablet is not a curable; it is only used to control the spreading of disease.

Sofosbuvir & Velpatasvir

Myhep all

400mg & 100mg


Myhep all indication and usage

Myhep all tablets are used only in adult’s patients with long lasting hepatitis C virus caused by genotypes I, II, III, IV, V or VI In two conditions Myhep all tablets are used;

Without cirrhosis or with compensated cirrhosis (child Pugh A or B) With decompensated cirrhosis by combining with ribavirin (child Pugh C)

Myhep all mechanism of action

Both the components in Myhep all tablets are involved in inhibiting nonstructural protein which is essential for viral multiplication. Sofosbuvir is a NS5B inhibitor, whereas Velpatasvir is considered as NS5Ainhibitor Myhep all is a directly acting anti-hepatitis C viral agent.

Sofosbuvir leads to produce pharmacologically active uridine analog triphosphate by intracellular metabolism. Sofosbuvir is inserted into viral HCV DNA by NS5B polymerase and act as a chain terminator. Velpatasvir inhibits NS5A protein which is responsible for viral assembly.

The peak plasma concentration time of Sofosbuvir and Velpatasvir is 0.5 to 1 hour and 3 hours respectively. The effect of food with Myhep all tablet determines as; With moderate meal: Sofosbuvir increases to 60%; increases to 34% With high fat meal: Sofosbuvir increases to 78%; increases to 21% The blood plasma ratio of Sofosbuvir & Velpatasvir is 0.7 & 0.52 to 0.67 respectively

The human plasma protein bound; Sofosbuvir & Velpatasvir is 61 to 65% &>99.5% respectively. The metabolism of Sovihep occurs; Sofosbuvir: cathepsin A, or carboxyl esterase Velpatasvir: CYP2B6, CYP2C8 or CYP3A4

The elimination of Myhep all occurs via; Sofosbuvir: Glomerular filtration, active tubular secretion Velpatasvir: biliary excretion The terminal half-life of Myhep all tablets; Sofosbuvir: 0.5 hours; GS331007: 25 hours & Velpatasvir 15 hours Elimination of Sofosbuvir in urine at 80%; feces at 14% Elimination of Velpatasvir in urine 0.4%; feces at 94%

Brand Myhep all
Ingredients Sofosbuvir & Velpatasvir
Strength 400mg & 100mg
Manufactured Mylan

Before initiation of therapy

Before starting the therapy, patient should be examined by counting hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) for confirmation of HBV infection. The usual recommended dosage of Myhep all tablet is one tablet should be administered as a single dose, by taking with or without food.

In new patients or experienced patients with or without cirrhosis

The prescribed dosage of Myhep all in this condition is one tablet should be taken as a single dose.

In new or already treated patients with decompensated cirrhosis

The prescribed dosage of Myhep all in this condition is one tablet to be taken as a single dose by combining with ribavirin.

The dosage of ribavirin

Based on body weight of the patients, the dosage of ribavirin should be recommended. Less than 75kg: 1000mg of ribavirin should be recommended At least 75kg: 1200mg of ribavirin should be recommended Ribavirin must be administered with food. Dosage adjustment should not be recommended in renal and hepatic impairment patients.

Over dosage

The over dosage of Myhep all tablets; If it occurs manage with supportive measures, and hemodialysis should be recommended for eliminating the components of Myhep all and its metabolite. Sofosbuvir is removed with the coefficient of 53%; Velpatasvir is highly bounds to human plasma protein and it is difficult to eliminate.

Myhep all causes undesirable effects

Headache, Fatigue, Nausea, Asthenia, Insomnia, Anemia, HBV reactivation, Elevation of lipase & amylase levels, Elevation of creatine kinase, Cardiac disorder like bradycardia while concomitant with amiodarone, Angioedema, Skin rashes

Myhep all precautions

Exposure of hepatitis B viral infection occurs in HBV/HCV co infections Serious symptomatic bradycardia while concomitant with amiodarone Risk of depletion of therapeutic effect occurs due to combination of Myhep all with P-gp inducers or CYP3A4 inducers.

Fetal adverse occurs while concomitant with ribavirin For all these conditions, withhold or discontinue the therapy with Myhep all tablets.

Myhep all drug interactions

  • P-gp or BCRP inducers combination with Myhep all causes depletion of plasma concentration of Myhep all leads to decreasing the therapeutic effect of Myhep all.
  • P-gp or BCRP inhibitors concurrent use with Myhep all tablets leads to increase the exposure of these drugs.
  • Variation in INR values occurs, while concomitant with warfarin.
  • Myhep all is concurrently used with gastric regulators, causes decreasing the plasma concentration of Velpatasvir.
  • Myhep all combined with amiodarone cause severe life threatening cardiac effects like bradycardia.
  • Myhep all combined with digoxin, causes increases effect of concentration of digoxin.
  • Myhep all tablets combined with anti-convulsants causes’ decrease in plasma concentration of Myhep all
  • Myhep all tablets with herbal product like st.Johns wort causes decreasing the effect of Velpatasvir.
  • Myhep all tablets combined with HMG CoA reductase inhibitors causes increasing the effedt of concentration of these drugs.

Myhep all contraindicated to

Myhep all is contraindicated to patients who are taking in combination with ribavirin.

Ribavirin is contraindicated to pregnancy condition.

Myhep all uses in specific condition

Pregnancy category of Myhep all : B Pregnancy category of Myhep all & ribavirin: X Ribavirin is not recommended for pregnancy condition. While concomitant with ribavirin, breast feeding should not be suggested.

The potency of Myhep all tablet has not been established in pediatric patients Renal & hepatic impairment patients: The safety of Myhep all tablets has not been established.

Myhep all tablet to be kept at the temperature below 30°C Protect the container away from moisture, heat and light.

If Myhep all dose is forgot to take, must consult with medical practitioner and follow the instruction. On the other hand, the missed dose should be skipped and follow the regular dosing schedule.

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