Nelvir is type of HIV-1 protease inhibitor and includes in group of anti-retroviral drugs. Nelvir needed for inhibition of HIV from reproducing in your body. The drug also required to treat a virus which cause acquired immunodeficiency syndrome. Nelvir is not cure for HIV or AIDS. Nelvir is prescription drug which is used under supervision of medical practioners.





Pharmacological action of Nelvir

Nelvir is used to treat patients affected by HIV-1 infection with combination of other antiretroviral drugs.

Mechanism of Nelvir

Nelfinavir which will join to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into divide the functional proteins necessary for infectious HIV. This will causes to immature formation, noninfectious viral particles.

ADME properties

AUC is highly variable in pediatric patients because increased clearance, problems with compliance and inconsistent food intake with dosing. The time to high plasma concentration is 2 to 4 hours.

Volume of distribution is 2 to 7 L/kg

Mainly metabolized through Hepatic via CYP2C19 and 3A4

The elimination of drug through feces 98% to 99% and as metabolite 78% and unchanged drug as 22% and through urine 1% to 2%.

Brand Nelvir
Ingredients Nelfinavir
Strength 250mg
Manufactured Cipla

Dosage and Administration

For adult the usual dose for HIV infections in patients administered as 1250 mg given orally twice a day or 750mg given orally 3 times a day The drug administer in combination with other antiretroviral agents for treatment of HIV-1 Infection.

For Non occupational Exposure the dose US CDC prescribed as 1250mg two times a day orally or 750mg three times a day orally given for 28 days. For pediatric dose age 2 to less than 13 years prescribed dose is 45 to 55 mg/kg given orally twice a day Or 25 to 35 mg/kg given orally three times a day. Maximum dose is 2500mg/day. Age 13 years or older = 1250mg given orally twice times a day or 750mg taken orally three times a day. The children weighing 16 kg or more administer 250mg for twice-daily

Side effects caused by Nelvir

Side effects by Clinical trials experience- adult and adolescents (13 yrs and older) Hemic/lymphatic system:
anemia, leucopenia and thrombocytopenia

liver function test abnormalities amylase, SGOT, SGPT, hypoglycemia, dehydration

Digestive system:
diarrhea, nausea, flatulence, epigastric pain

Skin /appendages:

Musculoskeletal system:
arthralgia, arthritis, cramps,myalgia

dyspnae, pharyngitis, rhinitis, and sinusitis.

Special sense:
acute iritis and eye disorder.

Postmarketing Expeience

Qtc prolongation, Jaundice, Hypersensitivity reaction, Bilirubinemia, metabolic acidosis.

Drug interaction

  • Concomitant use with antacids, Phenobarbital, carbamazepine, aminoglutethimide, phenytoin, rifampicin, nafcillin, nevirapine, omeprazole will reduce the levels of nevimune
  • Interaction of Nelvir with antifungal agents, cimetidine, Efavirenz wills increases serum levels.
  • Reduced plasma effects while concomitant use with hormonal contraceptives, methadone, theophylline derivatives


If patients have Diabetes mellitus/hyperglycemia. Inform the doctor before taking treatment with Nelvir

increased bleeding level with nelfinavir treatment

Fat distribution:
Risk of serious adverse reaction due to drug interaction

Hepatic impairment:
the drug should not be used

nelfinavir contains phenylalanine which is harmful to patients with phenylketouria. Immune Reconstitution Syndrome

Nelfinavir combination with CYP3A for clearance is contraindicated

Store at 15°C to 30°C Store the container closed tightly Dispense in original container

If you missed dose, have it soon If next dose time reached then avoid missed dose. And follow regular timings Please consult with doctor

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