> Nevivir 200 mg | HIV AIDS | Nevirapine (Hetero) | Buy tablet online | Blueberrypharma


Nevivir belongs to a group of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs) Nevivir is a prescription medicine recognized by the U.S FDA for the prevention of HIV infection in adults and children. Nevivir is always used in combination with other HIV medicines. Nevivir comes in three different forms: immediate-release tablets and oral suspension (a liquid), and extended-release tablets





Nevivir indication

Nevivir is indicated in co administration with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.

Mechanism of Nevivir

Nevivir isa type of non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. Nevivir interpolated directly to reverse transcriptase (RT) and prevents the RNA- dependent and DNA-dependent DNA polymerase action by making a division of the enzyme's catalytic site.

The activities of Nevivir have not refined with template or nucleoside triphosphates.

HIV-2 RT and eukaryotic DNA polymerases such as human DNA polymerases α, ß, γ, or δ are not prohibit by nevirapine.


Bioavailability in human is 93±9% and 91 ± 8% for oral solution and in rate is 89.7%. High plasma concentration is 2 ± 0.4 mcg/ml attained by 4 hours.

human Albumin of Plasma protein binding is 60%

Nevivir extensively bio transformed via cytochrome P450 and metabolized to several hydroxylated metabolites

Total radioactive in urine is 80% was made up of gluvuronide conjugation. The drug eliminated via urine 81.8 ± 11.1% and feces in 10.1 ± 1.5% Half life is 45 hours


Brand Nevivir
Ingredients Nevirapine
Strength 200mg
Manufactured Hetero

For adult recommended dose

In Co administration with other antiretroviral agents the recommended dose for Nevivir is one tablet of 200 mg daily for the first 14 days, followed by one 200 mg tablet twice daily, The 14-day lead-in period with Nevivir 200 mg daily dosing should be strictly followed as the lead-in period has been observed to decrease the incidence of rash.

If rash continueapart from the 14-day lead-in period, do not dose expand to 200 mg twice daily. The 200 mg once-daily dosing drugs should not be continued above 28 days, at which point, an alternative drugs should be desired. For combination administered antiretroviral therapy, Thenormal dosage and monitoring should be followed.

For pediatrics

The recommended oral dose for pediatric patients 15 days and older :150 mg/m 2 given once daily for period of 14 days followed by 150 mg/m 2 administered twice daily thereafter. The entiredose for daily should not exceed 400 mg for any patient.

Common side effects may include

Skin rash; or changes in the s location of body fat (specifically in your arms, legs, face, neck, breasts, and waist).

Serious side effects

Fever, night sweats, Swollen glands, Mouth sores, diarrhea, stomach pain, weight loss; Chest pain (specifically when you breathe), Dry cough, wheezing, feeling short of breath; cold sores, sores on your genital or anal area; Rapid heart rate, Feeling anxious or irritable, Weakness or prickly feeling, Problems with balance or eye movement; Trouble speaking or swallowing, Severe lower back pain, Loss of bladder or bowel control; or Swelling in your neck or throat (enlarged thyroid), Menstrual changes, Impotence, Loss of interest in sex.


Patients are contraindicated with moderate or severe (Child-Pugh Class B or C, respectively) hepatic impairment For indicated as part of occupational and non-occupational post-exposure prophylaxis (PEP) drugs.

Skin reaction

Serious and life-threatening skin reactions, involves fatal cases, have been reported in patients taking Nevivir .

Hepatotoxicity and hepatic impairment

Serious life-threatening in patient, and in some cases fatal hepatotoxicity, containing fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure, have been reported in patients treated with Nevivir .

Fat redistribution

Redistribution/aggregation of body fat involves central obesity, buffalo hump (dorsocervical fat enlargement), peripheral wasting, facial wasting, breast enlargement, and “cushingoid appearance” have been observed in patients receiving antiretroviral therapy

Drug interactions

Consolidation of Nevimunewith efavirenz is not recommended as this combination has been associated with an increase in adverse reactions and no improvement in efficacy.


Immune re-constituents

Immune reconstitution syndrome has been resulted in patients reacted with combination antiretroviral therapy, including Nevivir . During the initial phase of combination antiretroviral treatment, patients whose immune system behave may grow an inflammatory response to indolent or residual opportunistic infections (such as Mycobacterium avium infection, tuberculosis, cytomegalovirus or Pneumocystis jiroveci pneumonia), which may necessitate further evaluation and treatment.

In animal reproduction has no evidence of adverse problem but there is a severe risk in pregnant women solved to nevirapine.There is a pregnancy disclosure registry that monitors pregnancy outcomes in women exposed to Nevivir during pregnancy.

There is no information on the Nevivir effects of on milk production. Due to the possible for HIV-1 transmission (in HIV-negative infants), Introduction viral resistance (in HIV-positive infants), and severe adverse reactions in nursing infants, mothers should not breastfeed if they are gettingNevimune.

Store the drug between 68°F to 77°F (20°C to 25°C). Avoid using ofNevimuneif the original seal over the container opening is broken or missing. Throw away Nevimunethat is no longer needed or expired (out of date). how to safely dispose of unused medicine should Follow FDA guidelines. Keep Nevimuneand all medicines out of reach of children.

If patient missed a dose, patient should be consult with physician and follow the instructions. Follow the regular dosing schedule. Missed dose of drug should be avoided.


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