PAZOPANIB HYDROCHLORIDE 400MG
Votrient 400mg is an anticancer drug which inhibits the growth and spread of cancer cells in the body. Votrient is film-coated tablets, and a type of protein kinase inhibitors.
Votrient 400mg is indicated as a single agent for the treatment of kidney cancer and its advanced stage.
It works by inhibiting the activity of proteins which are interferes with the growth and spread of cancer cells.
Votrient 400mg is also indicated as a single regimen for the treatment of Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body).
The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs
MECHANISM OF ACTION
Votrient 400mg is an protein kinase inhibitor of multiple receptor tyrosine kinases (RTKs) that are elaborate in beginning of signal transduction pathways that start to reproduction of malignant cells and affect processes critical to cell survival and tumor progression.
RTKs involved in the obstruction include receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.
Votrient 400mg inadequately absorbed from the GI tract. Greater absorption with food. Bioavailability of Votrient: 14-39%. Duration of peak plasma concentration: 2-4 hr.
Plasma protein binding: >99%.
Votrient 400mg metabolized in the liver mainly by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Votrient 400mg mainly excreted through faces (approx. 82%, 67% as unchanged drug) and urine (<4%). Elimination half-life: Approx. 31 hr.
DOSAGE AND ADMINISTARTION
Votrient dosage for kidney carcinoma and soft tissue sarcoma will be initially 800mg, the dose adjustment in 200mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day.
Moderate total bilirubin >1.5 to 3 times, Votrient dose of 200mg once daily.
Votrient should be taken on an empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Avoid grapefruit juice or grapefruit juice.
Votrient 400mg Major side effects
Diarrhea, High blood pressure, low WBC; Elevated liver function test, Blood test abnormalities, increased in bilirubin levels.
Common Side effects
Nausea,, loss of appetite, fatigue, blood test abnormalities (low magnesium, low glucose), weakness, stomach ache.
Inform the prior to the treatment of Votrient 400mg tab about
Any other medications, which include in prescription, over the counters,vitamins,herbal remedies.
Do not take immunization or vaccination without doctors’ advice.
Inform your doctor about pregnancy and planning to pregnant. Do not breast feed while treatment with Votrient
Votrient 400mg with strong CYP3A4 enzyme inhibitors (e.g. ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin, atazanavir, indinavir, ritonavir, sqauinavir, nefazodone, lapatinib) will Increase plasma concentration. Votrient increases incidence of ALT elevation with simvastatin. Votrient 400mg with PPI e.g. esomeprazole decreases bioavailability.
Votrient 400mg with Concomitant use of strong of P-gp or BCRP inhibitors (e.g. lapatinib) and inducers may alter the exposure and distribution of pazopanib. Votrient 400mg with rifampin (strong CYP3A4 Enzyme inducers) will decreases the plasma concentration.