Penvir 500mg

Penvir 500mg is a type of classification of antiviral drugs. Penvir 500mg decrease the development and growth of the herpes virus in which body can fight against infection. For herpes has no treatment and Penvir 500mg will not prevents from growth of symptoms in the future.






Penvir 500mg indicated for the treatment or inhibition of herpes infections Penvir 500mg indicated for the treatment of cold sores.

Penvir 500mg indicated for the treatment for shingles.

Penvir 500mg indicated for the treatment of returning herpes simplex infections of the skin and mucus membranes (mouth, anus) in people with (HIV) infection.


Famciclovir readily go through biotransformation to penciclovir, which has preventory activity against HSV types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV).

Thymidine kinase then add phosphorus group to penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This blocks HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus prohibiting herpes viral DNA synthesis and multiplication.


Readily absorbed from the GI tract. The Penvir 500mg has Bioavailability: 77% (penciclovir) Time to peak plasma concentration 1 hr. Food may delay absorption.

Plasma protein binding of Penvir is <20%.

Converted to penciclovir through deacetylation and oxidation.

Penvir is eliminated via urine (73%); faces (27%). Elimination half-life of Penvir: 1.6-3 hr.

Brand Penvir
Ingredients Famciclovir
Strength 500mg
Manufactured Hetero

The recommended dose in Adult for tablet Penvir

Herpes Simplex – Suppression

The prescribed dose for Immunocompetent patientsis 250mg twice a day orally. The prescribed dose for HIV- Infected patients is 500mg twice a day orally.

Herpes Zoster

Dose given 500mg every 8 hours for 7 days orally.

Herpes Simplex Labialis

For Recurrent herpes labialis is1500mg single dose orally.

Herpes Simplex – Mucocutaneous / immunocompetent Host

For 7 to 10 days 250mg administrated 3 times a day given orally. Relapsed episodes are Given 1000mg twice a day for 1 day orally rather 125mg twice a day orally for 5 days.

Herpes Simplex – Mucocutaneous / immunocompromised Host

Relapsed episodes are 500mg twice a day for 7 days.


Penvir was well tolerated, if it occurs provide supportive and symptomatic treatment should be given as appropriately.

Less common side effects of Penvir 500mg

Redness of skin Mood or mental changes Hives or welts Itching skin Bloated, full feeling Excess air or gas in the stomach or intestines

More common side effects of Penvir 500mg

Heavy bleeding Headache Diarrhea Cramps

Incident not known side effects of Penvir 500mg

Dizziness Joint or muscle pain Pinpoint red spots on the skin Yellow eyes or skin Sores, ulcers or white spot in the mouth or on the lips. Black stools Bleeding gums Blistering, peeling of the skin


  • Susceptible to famciclovir, penciclovir cream (Danavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor

  • Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.

  • Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While takingPenvir treatment If you become pregnant, discuss with doctor about the condition.

  • Penvir may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.

Penvir 500mg Interaction with digoxin will slightly increase the digoxin in your blood. Famciclovir Concomitant use with probenecid will raise the level of Famciclovir in your blood and increase side effects.

Category B: In animal reproduction studies have not described a fetal harm but in human studies have no adequate studies carried out in the 1st trimester. Excretion of famciclovir into human milk has no data. On the safety of penciclovir in nursing infants has no data available. The drug should be avoided in breast feeding mother.

Store the tablet in a closed container Keep away from moisture, heat and direct light. Avoid freezing. Ask the pharmacist how to dispose the medicine left out.

if you missed any dose,Immediatelyadminister the medicine as you remember, If next dose time arrives then swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.

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