Pirfenex

Pirfenex Tablet is an effective drug, but it causes some life-threatening conditions.It causes an abnormal chromosomal structure, patient who are getting Tablet Pirfenex; exposing to light in genotoxicity tests.Patient must have knowledge about the potential of the drug Pirfenex which causes carcinogenesis in skin on exposed to light. PirfenexTablet should be prescribed under the supervision of medical practitioner who is familiar with the idiopathic pulmonary fibrosis therapy. PirfenexTablet is anti-fibrotic agent involved in the treatment of idiopathic pulmonary fibrosis (lung disease).

Pirfenidone

Pirfenex

200mg

Cipla






INDICATION OF PIRFENEX

PirfenexTablet is mainly used in the condition of Idiopathic Pulmonary Fibrosis (IPF).

Mechanism of action

Pirfenex , the mechanism of action of the drug is not completely established. Tablet Pirfenex is an effective anti-fibrotic and anti inflammatory agent. Anti-fibrotic activity of Pirfenex is mainly taken into consideration.

Pirfenex , number of cell based therapy takes place. It leads to reduce fibroblast proliferation, prohibits TGF-β accelerated collagen production, and decrease the synthesis of fibrogenic mediators like TGF-β (transforming growth factor).

Pirfenex has activity to reduce production of inflammatory mediators like TNF-α (tumor necrosis factor) and IL-1β (interleukin 1 beta).



Pharmacokinetic

The absorption of drug Pirfenidone is varying among the condition of the patient. In healthy persons, absorption occurs within 20-60mins. If tablet Pirfenex taken with food somewhat decrease the absorption. But in older adults, tablet Pirfenex is co administered with food leads to increase tolerability.

Tablet Pirfenex binds to plasma proteins, majorly with serum albumin. Within 1-3 hours of administration, protein binding was 54-62%.

Drug Pirfenidone is metabolized by liver. Approximately 48% of drug is metabolized via CYP1A2 with other CYP isoenzymes. The major metabolite is 5-carboxy-pirfenidone.

The elimination half life is around 2.4 hours. About 80% of the metabolites cleared in urine within 24 hours. PirfenexTablet after administration, excreted as major metabolite 5-carboxy-pirfenidone (95%), with less than 1% of drug Pirfenidone excreted consistent as well in the urine. Plasma concentration of the tablet Pirfenex (with or without meals), because of food C¬¬max and AUC decreased, Tmaxis significantly delayed.





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Pirfenex
Brand Pirfenex
Ingredients Pirfenidone
Strength 200mg
Manufactured Cipla
Rating

DOSAGE AND ADMINISTRATION of Pirfenex

The recommended dose of tablet Pirfenex in adolescent is 200mg for three times a day (TID), 600mg/day. Depending upon the severity of the condition (IPF), dosage may adjust up to 1800mg/day. Dosage of the tablet Pirfenex depending up on symptom. Initially patient starts with 200mg TID, after 2 weeks, dose may gradually increase to 600mg at a time (1800mg/day).

Dose adjustment and other consideration for safe use

Gastro intestinal events:
Patient, during therapy with tablet Pirfenex may affected by gastrointestinal side effects, so patient advice by taking tablet Pirfenex with food. If a symptom endures means, dose may reduce to 1-2 tablets given for 2-3 times a day with food.

Photo sensitive reactions:
If rashes sustains for 7 days, tablet Pirfenex should be discontinued for 14 days. It is continued by the guidance of health care providers.

Most common side effects caused by Pirfenex include

Photosensitivity reactions like rashes, Loss of appetite, Stomach discomfort, Nausea, Increased AST and ALT levels, Fatigue, Diarrhea, Dyspepsia

ADVERSE REACTIONS

Upper respiratory tract infections, UTI, Agranulocytosis, Angioedema, Anorexia, weight decreased, loss of appetite, Insomnia, Headache, dizziness, somnolence, dysgeusia, lethargy, Hot flush, Dyspnea, cough, Gastro esophageal reflux, vomiting, constipation, gastritis. ALT, AST increased, serum albumin increased.

Pirfenex tablets should be taken with caution

In the conditions like:

  • Hepatic toxicity – intiate the liver function test before starting treatment with Pirfenex for first 6 months nd every 3 months
  • Photosensitivity – risk of rash and other reactions may occur, sunscreen and protective clothing, limit exposure to sunlight is important.and rash and photosensitivity reaction should be reported immediately.
  • Gastrointestinal disorders: clinical studies shown nausea, vomiting, abdominal pain, dyspepsia, diarrhea GERD wre frequently observed while on treatment with Pirfenex then in those taking placebo. Inform your doctor, dosage modification is important in case of GI adverse reaction.

Drug- drug interaction

PirfenexTablet has some of drug interactions, which is propitiating by cytochrome enzymes:

  • Tablet Pirfenex is metabolized through the CYP1A2 enzyme pathway.
  • The various drug which inhibits this cytochrome enzyme leads to accumulation of toxicity of Pirfenidone.
  • Some of the CYP1A2 inhibitors medicines like Fluoxamine, ciprofloxacin, amiodarone etc.
  • These are strong inhibitors like paroxetine, fluconazole, and chloramphenicol
  • Omeprazole is used cautiously with tablet Pirfenex , might have chance to reduce the plasma level of the drug Pirfenidone.
  • Smoking during the treatment with tablet Pirfenex causes increased clearance of Pirfenidone.

contraindications

Pirfenex tablets are contraindicated to the patient having hypersensitivity to active ingredient Pirfenidone. Other conditions; Angioedema with Pirfenidone Adjuvant use of Fluoxamine Severe hepatic and renal impairment



Category C :Animal studies have revealed an adverse reaction and there are no sufficient studies in pregnant women but probably use the drug with caution in pregnant women possibly show against risks.

Pirfenex 200mg is excreted into breast milk taking account on this, discussion should done on whether to discontinue the breast feeding or the drug. Use of drug is contraindicated during breastfeeding. It is unclear the effect of new born babies.

Tablet Pirfenex should be stored at the temperature below 25°C. The container should be kept in cool and dry place.

If a dose is missed, then have the dose as soon as possible before the next dose timing or skip the missed dose and continue daily schedule. Do have extra dose for any cost Please consult with the doctor for further details.

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