Posid 100mg Injection

Posid 100mg Injection is a cancer medicine which prevents the growth and spread of cancer cells in the body.
Posid 100mg Injection is necessary to treat small cell lung cancer. It is normally administrated in combination with other cancer medicines.
Posid 100mg can be given into the vein or as injection.
Posid 100mg is a prescription drug provided under guidance of medical practioners.

Etoposide

Posid

100mg

Cadila Pharmaceuticals Ltd




INDICATION

The drug Posid 100mg Injection indicated in concomitant with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer.

MECHANISM

Etoposide prevents DNA topoisomerase II, thereby blocking DNA re-ligation. This causes detracting errors in DNA synthesis at the premycotic level of cell division and causes apoptosis of the tumor cell. The drug is cell cycle dependent and phase specific, affecting primarily the S and G2 phases of cell division. prohibition of the topoisomerase II alpha isoform occurs in the anti-tumour activity of etoposide. The drug is also capable of preventing the beta isoform, but inhibition of this target is not analogue with the anticancer activity. It is instead along with the carcinogenic effect.



Pharmacokinetic

Peak plasma time is 1 hr
Bioavailability are 25-75%
Peak plasma concentration is 4.7 mcg/mL
Clearance: 13.4 mL/min

Protein bound: 94-98%
Vd: 7-17 L/m²

Metabolized in Liver

Half-Life: 4-11 hr
Excretion: Urine (35%)




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drug
Brand Posid
Ingredients Etoposide
Strength 100mg
Manufactured Cadila Pharmaceuticals Ltd
Rating

DOSAGE AND ADMINISTRATION

For testicular cancer :
The recommended dose is 50-100mg/m2/day Iv on days 1-5 or 100mg mg/ m2/day IV on days 1,3,5
Repeat the course for q3-4week
For small-cell lung cancer :
The recommended dose is 35 mg/ m2/day IV for 4 days or 50 mg/ m2/day IV for 5 days
Repeat the course for q3-4week
Monitor the patients CBC, Hgb, LFTs, Renal function

SIDE EFFECTS

Common side effects :
• Low WBC count
• Low platelet count
• Loss of hair
• Menopause
• Fertility loss
• Vomiting and nausea
• Low blood pressure.
Less common side effects :
• Mouth ulcers
• Diarrhae
• Decreased appetite
• Radiation Recall
Other side effects :
• Metallic taste during drug infusion
• Inflammation at Capsules site

PRECAUTIONS

If platelet <50,000/mm³ or ANC <500/mm³, withhold further treatment
If patient have hepatic impairment use with caution
The drug Posid 100mgshould not inject rapidly it may cause hypotension to patient; infuse over at least 30-60 min
During administration Injection site reactions may occur; check closely
Avoid pregnancy

DRUG – DRUG INTERACTION

  • When combination of Posid 100mg with Apalutamide will reduces the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

  • When combination of Posid 100mg with idelalisib will increase the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

  • Posid 100mg will decrease the effects of influenza virus vaccine trivalent adjuvanted by pharmacodynamic antagonism

  • When combination of Posid 100mg with Nefazodone will increase the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Contraindications


The drug Posid 100mg contraindicated to hypersensitivity to etoposide or any component of the formulation



Posid 100mg has pregnancy category D
While administrating to a pregnant woman will cause fetal harm. Hence the drug during pregnancy

Advice breastfeed mother about possible risk to the fetus. Avoid breastfeeding during treatment

Posid 100mg should be stored under refrigeration at 2°C - 8°C. Dispense the drug in tight container

If the patient vomits after taking a dose of drug or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.

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