Renodapt- S 360mg

Renodapt-s 360mg (inactive form) is a prodrug of Mycophenolic acid (MPA) and it is an immunosuppressive drug. Following oral administration, mycophenolate mofetil is fastly absorbed and hydrolysed (converted) to Mycophenolic acid.
Mycophenolic acid (MPA) is the active metabolite which has pharmacological activity.
Renodapt-s 360mg is a prescription drug provided under the supervision of doctors.

Mycophenolate Mofetil

Renodapt- S


Biocon Pharmaceuticals


Renodapt-s 360mg is indicated for the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants.
Renodapt-s 360mg should be used concomitantly with cyclosporine and corticosteroids.

Mechanism of action

Renodapt- S is the 2-morpholinoethyl ester of MPA. MPA (Mycophenolic acid) is a potent, selective, uncompetitive and reversible prohibitor of inosine monophosphate dehydrogenase, and thereby prevents the de novo pathway of guanosine nucleotide development without fusion into DNA.
Because T- and B-lymphocytes are mortally weak for their replication on de novo synthesis of purines although another cell types can utilise salvage pathways, Mycophenolic acid has more potent cytostatic effects on lymphocytes than on other cells.


In oral administration, rapidly absorbed and bioavailability are 94% for oral Mycophenolate mofetil relative Mycophenolate mofetil intravenous.

The active metabolite MPA bounded to plasma protein is 98%.

Mainly metabolised by glucuronic transferase to form inactive phenolic glucuronide of MPA.

Renodapt-s 360mg is completely recovered with 93% dose in urine and 6% via feces and 87% administrated dose excreted via urine as MPAG
Half-life of Renodapt- S is 13-17 hours

Brand Renodapt- S
Ingredients Mycophenolate Mofetil
Strength 360mg
Manufactured Biocon Pharmaceuticals

Renodapt- S is mainly required for preventions of organ transplant of kidney, heart and liver, the dosage as follows
Kidney transplantation :
For Adult the prescribed dose is 1 g given orally or intravenously (over no less than 2 hours) twice a day.
For paediatric (3 months to 18 years of age) the prescribed dose of the oral suspension is 600 mg/m2 given twice daily (maximum daily dose of 2 g/10 ml).
Dosage also calculated according to body surface area :
Patients with a body surface area of 1.25 m2 to 1.5 m2 may be taken capsules at a dose of 750 mg twice daily.
Patients with a body surface area >1.5 m2 may be administrated with capsules or tablets at a 1 g dose twice daily.
Heart transplantation :
For Adults the usual dose is 1.5 g given twice daily intravenously over no less than 2 hours or 1.5 g administrated orally twice daily.
Liver Transplantation :
For Adults the prescribed dose is 1 g twice daily given via intravenously over no less than 2 hours or 1.5 g orally twice daily.
For Geriatrics (elderly patients) the prescribed orally is 1 g dose twice daily for renal transplant patients, 1.5 g dose given twice daily for heart transplant patients, and 1 g dose twice in a day administered intravenously or 1.5 g dose twice in a day administered orally in liver transplant patients.

Side effects

Abdominal pain
Swelling of the ankles or feet, lower legs.
Serious side effects :
Infection in blood
Low RBC, and WBC


Embryofoetal Toxicity :
Renodapt-s 360mg can leads risk to foetal when administered to a pregnant female. While Use of Renodapt during pregnancy is along with an increased risk of first trimester pregnancy loss and have high risk of congenital malformations
Lymphoma and Malignancy :
Patients administrating immunosuppressive drug containing combinations of drugs, involves Renodapt-s 360mg, as part of an immunosuppressive regimen have high risk of developing lymphomas and other malignancies, specifically effect the skin
Pregnancy Exposure Prevention and Planning :
Females of reproductive probably should be made aware of the high risk of first trimester pregnancy loss and congenital malformations and must be advise about pregnancy prevention and planning
Combination with Other Immunosuppressive Agents :
Renodapt-s 360mg has been given in co administration with the following agents in clinical trials: antithymocyte globulin(ATGAM®), OKT3 (Orthoclone OKT® 3), cyclosporine (Sandimmune®, Neoral®) and corticosteroids should be avoided.


  • When Renodapt-s 360mg combination with acyclovir or ganciclovir may causes increases blood levels Renodapt- S and interacting drugs elimination through kidneys the drugs complete with each other

  • Renodapt-s 360mg Interaction with antacid may decrease MPA blood levels

  • Interaction with proton pump may decrease blood levels by binding in the intestine.

  • Renodapt-s 360mg combining with birth control pills may reduce the effectiveness of some oral contraceptives

  • Probenecid may cause an high in MPA blood levels by prohibiting its excretion through renal tubular secretion


Renodapt-s 360mg is contraindicated to the patients having with;
Hypersensitivity to mycophenolate mofetil
Allergic to polysorbate 80 (tween)
Pregnant women
Breastfeeding women

Pregnancy category D
Using of Renodapt-s 360mg during pregnancy will have increased risk of 1st trimester loss and risk of congenital malformations

Avoid using Renodapt-s 360mg during breast feeding to infants

Renodapt-s 360mg Stored at 25°C
Dispense in a tight, light resistant container

If dose is missed, have it soon before next dose reaches or skip the dose and follow normal
Please Consult with the doctor

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