Rolimus 10mg

Rolimus 10mg belongs to anti-neoplastic agent; it comes under mTOR kinase inhibitor (single transduction inhibitor). Rolimus 10mg is an immunosuppressive macrolide.




Cipla Ltd

Used for

Breast cancer
patient who fail to respond the tablet letrozole or anastrozole therapy, would be treated with Rapact. Rolimus 10mg is used in advanced stage of breast cancer.

Neuroendocrine tumors
Rolimus 5mg involved in the treatment of some neuroendocrine tumors like pancreatic, gastrointestinal or lung cancer.

Renal cell cancer
patient treating with Rolimus 10mg after the failure of treatment with Sunitinib or Sorafenib.
Rolimus 10mg also used in the condition of;
Heart, liver, kidney transplantation
Waldenström macroglobulinemia
Other carcinoid tumors.

Mechanism of action

Rolimusis prohibitor of mammalian target of rapamycin (mTOR), a serine threonine kinase.
Rolimusbind with intercellular protein (FKBP-12), leads to inhibitory complex formation with mTOR complex 1 (mTORC1) this leads to inhibition of mTOR kinase activity.
Rolimusdecreased the effect of S6 ribosomal protein kinase (S6K1) and eukaryotic elongation factor 4E binding protein (4E-BP1) which are essential for protein synthesis.
mTOR inhibited by Rolimuslead to reduce cell multiplication and angiogenesis.


The peak plasma concentration of Rolimusreached within 1 to 2 hours after administration.

The blood plasma ratio of Rolimus occurs over the range of 5 to 5000ng/ml.

On oral administration, Rolimusis metabolized into six main metabolites;
Three monohydroxylated
Two hydrolytic ring opened product
Phosphatidylcholine conjugate of Rapact.
Rolimusis a substrate of CYP3A4 and PgP.
Rolimusis mixed inhibitor of CYP2D6 substrate dextromethorphan
Rolimusinhibits the metabolism of CYP3A4.

The 80% of the drug eliminated through feces. The half-life time of drug Rolimusis approximately 30 hours.

Brand Rolimus
Ingredients Everolimus
Strength 10mg
Manufactured Cipla Ltd

Dosage and administration

The recommended dose of the Tablet Rolimusis 10mg should be taken as a single dose in all carcinogenic condition, except organ transplantation.
Organ transplant: 0.75mg orally twice daily.
Brain/intracranial tumor: 4.5mg/m2 orally once a day (for both pediatric and adult dose)
Hepatic impairment: dose reduced to 7.5mg once daily followed by 5mg as a single dose.
Rolimusis in tablet form. It should be administered orally at same time every day.
Rolimusshould be taken with or without food.
Rolimustablets should not crush or broken.

Over dosage

The over dosage of Rolimus 10mg is rarely occur, in case of over dosage patient must be provide with supportive measures. The acute toxicity of Everolimus over dosage should be monitored.


The side effects of Rolimus 10mg tablets are predicted by the terms of their onset, duration, and severity
Side effects of Rolimus 10mg is preventable and it is minimized :
Mouth sores, Mucositis, Stomatitis or esophagitis, Infection, Rash, itching or dry skin, Fatigue, Diarrhea, Edema, Stomach pain, Nausea, vomiting, Fever, Weakness or asthenia, Headache.

Blood test abnormalities

Hypercholesterolemia, High triglycerides, High blood sugar level, Low calcium, Low phosphate, Low blood counts, Liver problems, Kidney problems.

Less common

Cough, Loss appetite, Shortness of breath, Hypertension, Bleeding problems, Joint pain, Muscle pain, Loss of fertility.


Before going to start the Rolimus 10mg therapy, doctor should consult with patient whether they are taking any medicines like; Aspirin
Any kind of immunization or vaccine
Care should be taken in pregnancy co

Drug interaction

Some list of medications should not be taken with Tablet Rapact, they will interact with Rolimus 10mg to produce serious ill;
Angiotensin converting enzyme inhibitors: Rolimus 10mg increases the adverse effect of ACE inhibitors.
Anti-diabetic agents
Anti-hepaciviral increase the serum concentration of Rolimus 10mg
Vitamin D
Fish oil

Rolimus 10mg is contraindicated to sirolimus and other rapamycin derivatives, to produce anaphylactic reactions.

Rolimus 10mg should not use in pregnancy conditions and for breastfeeding mothers. Pregnancy category: C
Rolimus 10mg causes harm or any malformation in unborn babies.

Rolimus 10mg should be stored in room temperature
Keep away from moisture, heat and light

In case of missed dose, patients must consult with medical practitioner and follow the instructions given by them.
On the other hand, the missed dose should be avoiding and follow the regular dosing schedule.

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