Jakavi 15mg is indicated for the treatment in patients with intermediate and high-risk myelofibrosis.



14 tablets


Jakavi 15mg is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor.
Jakavi 15mg works by blocking certain enzymes in the body that affect blood cell production.
Jakavi 15mg is prescription drug provided under supervision.


Ruxolitinib belongs to kinase inhibitor which is selective for the Janus analogue Kinases (JAK) 1 and 2. These kinases are necessary for the mediation of cytokine and growth factor signalling which in turn effect immune function and hematopoiesis. The signalling process contains signal transducers and transcription activators (STAT) which modulate gene expression. Patients having myelofibrosis contain abnormal JAK1 and JAK2 activity,henceRuxolitinibfunction to regulate this.


Rapid absorption and not affected by food maximum plasma level is 1.5 hours.

Volume of distribution is 76.6 L plasma protein

Metabolized by CYP3A4

Excreted through urine 74% and unchanged drug is <1% and through urine 22% ,<1 % as unchanged drug


Ingredients Ruxolitinib
Strength 15mg
Pack 14 tablets


Myelofibrosis :
Kinase inhibitor uses for treatment of patients with intermediate or high-risk myelofibrosis, involving mainly myelofibrosis, post-polycythemiavera myelofibrosis and post-essential thrombocythemia myelofibrosis
Starting recommended doses for myelofibrosis :
If Platelet count >200 x10^9/L the dose given is 20 mg PO BID
If Platelet count 100-200 x10^9/L the dose given is 15 mg PO BID
If Platelet count 50 to <100 x10^9/L the dose given is 5 mg PO BID
Titrate dose based on response; not to exceed 25 mg PO BID
Polycythemia Vera :
The recommended dose is 10mg PO BID
Undergo CBC and platelet count prior starting and q2-4wk until doses are stabilized, and then as clinically used.


Common side effects :
• Anemia
• Thrombocytopenia
Serious side effects :
• Increased liver enzymes
• Diarrhea
• Bruising
• Swelling
• Neutropenia
• Dizziness
• Increased cholesterol
• Shortness of breath
• Nasopharyngitis
• Headache
• Constipation
• Nausea & Vomiting
• Insomnia.


Treatment with Jakavi 15mg can resulted in thrombocytopenia, anemia and neutropenia. Control thrombocytopenia by decreasing the dose or temporarily interfere with Jakavi 15mg. Platelet transfusions may be necessary.
Risk of infection occurs by delay initiate treatment with Jakavi 15mg until active severe infection have resolved.
Tuberculosis infection has been reported in patients receiving Jakavi 15mg. Observe patients receiving Jakavi 5mg for signs and symptoms of active tuberculosis and manage promptly.
Progressive multifocal leukoencephalopathy (PML) has occurred with Jakavi 15mg treatment. If PML is suspected, stop Jakavi 5mgand evaluate
Non-melanoma skin cancers including basal cell, squamous cell, and Merkel cell carcinoma have occurred in patients treated with Jakavi 15mg. Perform periodic skin examinations.


  • Interaction with fluconazole doses greater than 200mg daily may increase Ruxolitinib exposure leads to increase the risks of exposure related adverse reaction.
  • Combination of Jakavi 15mg with strong CYP3A4 inhibitors will increases Ruxolitinib exposure.
  • Combination of Jakavi 15mg with strong CYP3A4 inducers will decreases Ruxolitinib exposure.



There are no studies with the use of Jakavi 15mg in pregnant women to inform drug-associated risks. Hence avoid becoming pregnancy during Jakavi 15mg treatment

Avoid breast feeding during treatment with Jakavi 15mg. Excretion into human milk is unknown.

Jakavi 15mg stored at 20°C to 25°C.
Protect away from light and moisture
Dispense in its original container

If dose is missed the have the dose immediately before next dose timing reaches or skip the missed dose and continue the regular schedule.
Consult doctors regarding missed dose.

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