Sprycel 70mg

Sprycel 70mg is a potent, which contains ATP-competitive tyrosine kinase inhibitor. It is also belonging to second-generation inhibitor of the oncogenic tyrosine kinase BCR-ABL with 325-fold more potency than imatinib and is also able to inhibit imatinib-resistant BCR-ABL mutants.
Sprycel 70mg is a prescription drug which used under the supervision of doctor.

Dasatinib

Sprycel

70mg

BMS India Pvt ltd




INDICATION

Sprycel 70mg the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukaemia with resistance or intolerance to prior therapy.
Philadelphia chromosome-positive acute lymphoblastic leukaemia with resistance or intolerance to prior therapy.

Mechanism of action

Dasatinib is a group of drugs called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that works as chemical messengers to stimulate cancer cells to develop. Dasatinib inhibits the tyrosine kinases from sending chemical signals which tell the cells to grow.



Pharmacokinetic

Volume of distribution 2505 L and plasma protein binding is 96%

Extensively metabolized in humans, mainly by the cytochrome P450 enzyme 3A4.

Dasatinib excreted through the feces.Half-life is 3-5 hours



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drug
Brand Sprycel
Ingredients Dasatinib
Strength 70mg
Manufactured BMS India Pvt ltd
Rating

Sprycel indicated for Chronic Myeloid Leukaemia:

Newly diagnosed
The recommended dose: starting 100 mg PO qDay (morning or evening).
May raised to 140 mg qDay if insufficient response.
Advanced CML
The recommended dose: starting 140 mg PO qDay
May increase to 180 mg qDay if insufficient reactions
Sprycel indicated for Acute Lymphoblastic Leukaemia:
The recommended dose: starting 140 mg PO qDay
May increase to 180 mg PO qDay if insufficient reactions

Side effects

• Anemia
• Skin rash
• Infection
• Nausea
• Dyspnea
• Anorexia
• Arthralgia
• Asthenia
• Constipation
• Dizziness
• Musculoskeletal pain
• Febrile neutropenia
• Thrombocytopenia
• Mucosal inflammation
• Diarrhea
• Headache
• Haemorrhage
• Fatigue
• Pyrexia

Precautions

• Myelosuppression contains severe thrombocytopenia, neutropenia and Anemia may develop; may manage by dose interruption, dose reduction, or stopping of treatment; hematopoietic growth factor has been used with resistant myelosuppression
• some patients with chronic phase CML and paediatric Ph+ ALL, show complete blood cell counts (CBCs) q2Weeks for 12 weeks, then q3Months thereafter, or as clinically indicated; show CBCs for the first 2 months weekly after that monthly, or as clinically indicated in patients with advanced phase CML or Ph+ ALL
• Sprycel will occur Hypokalaemia, hypomagnesemia, congenital QT interval prolongation, hepatic impairment
• Sprycel should Use with caution in patients who have or may develop prolongation of QT interval

DRUG – DRUG INTERACTION

  • Sprycel 70mg combination with CYP3A4 inhibitors will increase Dasatinib plasma concentration.
  • Sprycel 70mg combination with CYP3A4 inducers will decrease Dasatinib plasma concentration.
  • Sprycel 70mg combination with antacids will decrease Dasatinib plasma concentration.
  • Sprycel 70mg combination with H2 antagonists/proton pump inhibitors will decrease Dasatinib plasma concentration.
  • Sprycel 70mg combination with CYP3A4 substrates will have their plasma concentration altered by Dasatinib.



Sprycel 70mg will cause fetal harm while using during pregnancy. Advise a pregnant woman of the possible risk to a foetus

Avoid breast feeding during Sprycel treatment

Stored at 20°C to 25°C .

In case of missed dose, patients must consult with medical oncologist and follow the regular dosing schedule.


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