In our body the immune system helps to fight against infection and reject a transplanted organ entering the body (such as liver, kidney, heart). Therefore, Tacromus 0.5mg is an immunosuppressive drug (also known as Fujimycin) which reduce the action of immune system in our body (immune system treats the new organ as invader), thereby Tacromus 0.5mg combined with other, it will inhibit the immune system rejection of heart, liver or kidney transplant of our body.
INDICATIONS OF Tacromus 0.5MG
Tacromus 0.5mg is an immuno suppressive which is used with other medication to inhibit rejection of a Kidney, heart or liver transplant.
Tacromus 0.5mg is indicated for reduce the inflammation associated with ulcerative colitis Tacromus 0.5mg is also used in treatment of eczema.
HOW Tacromus 0.5MG ACTION WORKS
Tacrolimus prevents the T-lymphocyte activation.
The drug binds to a protein (FKBP- 12) inside the cell and forms complex of Tacrolimus - FKBP-12, calcium, calmodulin, and calcineurin.
The alteration of nuclear factor of activated T- cells(NF-AT), an nuclear component which initiate gene transcription for the formation of lymphokines (as interleukin-2, gamma interferon). Finally, results prevention of T-lymphocyte activation.
Oral Slowly absorbed in the GI tract, total bioavailability 20 to 25%, highest blood plasma concentration reached after 1-3hrs. With food: Slows down resorption and reduces bioavailability
In the blood Tacrolimus is mainly bound to erythrocytes, plasma 5%, plasma protein binding 98.8%.
Tacrolimus is metabolized in liver, mainly via CYP3A and in the intestinal wall.
Tacrolimus exerted through feces in form of its metabolites. Biological half-life 43 hrs. (healthy), liver transplation person 12hrs, for kidney transplation 16 hrs.
HOW Tacromus 0.5MG ADMINISTRATED AND DOSING
Organ Transplant in adult dose – Rejection prophylaxis
Initial dose: 0.03 to 0.05 mg/kg/day (IV infusion continuous) for 6 hours after transplantation. High dose: 0.1mg/kg/day continuous IV infusion. Tacromus combination with azathioprine: initial dose 0.1mg/kg orally every 12hours. Initiate within 24 hours surgery. In combination with mycophenolate: Initial dose 0.05mg/kg orally every 12hours started with 24hrs of surgery
Initial dose: 0.05 to 0.075mg/kg orally every 12hrs. Initiate not more than 6 hrs. after surgery For IV: initial dose 0.03 to 0.05 mg/kg/day as a continuous IV infusion.
Initial dose: 0.0375mg/kg/orally every 12 hrs. Initiate 6 hrs after surgery. For IV initial dose: 0.1mg/kg/day continuous IV infusion.
Graft versus host disease in adult
Initial dose: 0.03mg/kg/day, initiate at least 24hrs before to stem cell infusion.
IV: initial dose 0.03mg/kg/day (continuous infusion) To convert IV to oral then multiply total daily IV dose 4 times and administer in 2 divided oral dose /day, every 12hrs.
Pediatric dose for organ transplant – Rejection Reversal
Initial dose: 0.075 to 0.1 mg/kg orally every 12 hrs. IV, Initial dose: 0.03 to 0.05 mg/kg/day as continuous infusion
Graft versus host disease
IV, initial dose 0.03 mg/kg/day (continuous IV), started at least 24 hrs. before to stem cell infusion, it used only if oral medication can be tolerated.
IF OVERDOSE OCCURS
Tacromus overdose may leads to passing out or breathing trouble. Call emergency medical or poison control for rapid action.
Severe side effects
Liver and kidney problem,
Increase in potassium, glucose level,
herpes zoster or polyoma
Carcinogenesis and mutagenesis:
Non- Hodgkin’s lymphoma
Topical use common:
burning or itching sensation; less common flu like symptoms, head pain.
BEFORE USE OF Tacromus 0.5MG CARE TO BE TAKEN
Avoid Tacromus 0.5mg , if you allergic to its own or hydrogenated castor oil, cyclosporine with the past 24 hrs.
Discuss with doctor, if Tacromus 0.5mg used for longer periods of time, it wil develop skin cancer, that weaken immune system and the possible risk.
Inform early to doctor about Have kidney or liver disease; Have cardiac disease, hypertension, hyperlipidemia or triglycerides (a type of fat in the blood); a cardiac rate disorder or history of long QT syndrome; taking heart rhythm medication; or usage of other medications that can weaken your immune system pregnancy, not known whether harm unborn baby while Tacromus 0.5mg therapy, avoid breast feed.
Tacromus 0.5mg interact with
Aluminum/magnesiumantacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, causes increase the level of potassium in the blood and with other drugs ( natalizumab, rituximab) will weaken the immune system and increase the risk of infection.
Cimetidine, danazol, nefazodone, ethinyl estradiol, methylprednisolone , antifungal drugs, rifamycin, anti-seizure will remove tacrolimus from the body and affect its work.