Tacromus 1mg

In our body the immune system helps to fight against infection and reject a transplanted organ entering the body (such as liver, kidney, heart). Therefore, Tacromus 1mg is an immunosuppressive drug (also known as Fujimycin) which reduce the action of immune system in our body (immune system treats the new organ as invader), thereby Tacromus 1mg combined with other, it will inhibit the immune system rejection of heart, liver or kidney transplant of our body.

Tacrolimus

Tacromus

1mg

Zydus




INDICATIONS OF Tacromus 1mg

Tacromus 1mg is an immuno suppressive which is used with other medication to inhibit rejection of a Kidney, heart or liver transplant.

Tacromus 1mg is indicated for reduce the inflammation associated with ulcerative colitis Tacromus 1mg is also used in treatment of eczema.

HOW Tacromus 1mg ACTION WORKS

Tacrolimus prevents the T-lymphocyte activation. The drug binds to a protein (FKBP- 12) inside the cell and forms complex of Tacrolimus - FKBP-12, calcium, calmodulin, and calcineurin.

The alteration of nuclear factor of activated T- cells(NF-AT), an nuclear component which initiate gene transcription for the formation of lymphokines (as interleukin-2, gamma interferon). Finally, results prevention of T-lymphocyte activation.



Pharmacokinetic

Oral Slowly absorbed in the GI tract, total bioavailability 20 to 25%, highest blood plasma concentration reached after 1-3hrs. With food: Slows down resorption and reduces bioavailability

In the blood Tacrolimus is mainly bound to erythrocytes, plasma 5%, plasma protein binding 98.8%.

Tacrolimus is metabolized in liver, mainly via CYP3A and in the intestinal wall.

Tacrolimus exerted through feces in form of its metabolites. Biological half-life 43 hrs. (healthy), liver transplation person 12hrs, for kidney transplation 16 hrs.




Blueberrypharma.com-img1

Tacromus 1mg
Brand Tacromus
Ingredients Tacrolimus
Strength 1mg
Manufactured Zydus
Rating

HOW Tacromus 1mg ADMINISTRATED AND DOSING

Organ Transplant in adult dose – Rejection prophylaxis

Kidney transplant
Initial dose: 0.03 to 0.05 mg/kg/day (IV infusion continuous) for 6 hours after transplantation. High dose: 0.1mg/kg/day continuous IV infusion. Tacromus combination with azathioprine: initial dose 0.1mg/kg orally every 12hours. Initiate within 24 hours surgery. In combination with mycophenolate: Initial dose 0.05mg/kg orally every 12hours started with 24hrs of surgery

Liver transplant
Initial dose: 0.05 to 0.075mg/kg orally every 12hrs. Initiate not more than 6 hrs. after surgery For IV: initial dose 0.03 to 0.05 mg/kg/day as a continuous IV infusion.

Heart transplant
Initial dose: 0.0375mg/kg/orally every 12 hrs. Initiate 6 hrs after surgery. For IV initial dose: 0.1mg/kg/day continuous IV infusion.

Graft versus host disease in adult

Prevention
Initial dose: 0.03mg/kg/day, initiate at least 24hrs before to stem cell infusion.

Treatment
IV: initial dose 0.03mg/kg/day (continuous infusion) To convert IV to oral then multiply total daily IV dose 4 times and administer in 2 divided oral dose /day, every 12hrs.

Pediatric dose for organ transplant – Rejection Reversal

Liver transplant
Initial dose: 0.075 to 0.1 mg/kg orally every 12 hrs. IV, Initial dose: 0.03 to 0.05 mg/kg/day as continuous infusion

Graft versus host disease

Prevention
IV, initial dose 0.03 mg/kg/day (continuous IV), started at least 24 hrs. before to stem cell infusion, it used only if oral medication can be tolerated.

IF OVERDOSE OCCURS

Tacromus overdose may leads to passing out or breathing trouble. Call emergency medical or poison control for rapid action.

Severe side effects

Cardiac damage, Liver and kidney problem, Increase in potassium, glucose level, Diabetes mellitus, Hypomagnesemia, Lung damage

Fungal infection:
herpes zoster or polyoma

Carcinogenesis and mutagenesis:
Non- Hodgkin’s lymphoma

Topical use common:
burning or itching sensation; less common flu like symptoms, head pain.

BEFORE USE OF Tacromus 1mg CARE TO BE TAKEN

Avoid Tacromus 1mg , if you allergic to its own or hydrogenated castor oil, cyclosporine with the past 24 hrs. Discuss with doctor, if Tacromus 1mg used for longer periods of time, it wil develop skin cancer, that weaken immune system and the possible risk.

Inform early to doctor about Have kidney or liver disease; Have cardiac disease, hypertension, hyperlipidemia or triglycerides (a type of fat in the blood); a cardiac rate disorder or history of long QT syndrome; taking heart rhythm medication; or usage of other medications that can weaken your immune system pregnancy, not known whether harm unborn baby while Tacromus 1mg therapy, avoid breast feed.

Tacromus 1mg interact with

Aluminum/magnesiumantacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, causes increase the level of potassium in the blood and with other drugs ( natalizumab, rituximab) will weaken the immune system and increase the risk of infection.

Cimetidine, danazol, nefazodone, ethinyl estradiol, methylprednisolone , antifungal drugs, rifamycin, anti-seizure will remove tacrolimus from the body and affect its work.



Hypersensitivity reaction by Tacromus 1mg , the symptoms reported dyspnea, rash, pruritis and acute respiratory distress syndrome.

Category C: In animal studies described that in reproduction there is an adverse reaction on fetus and there are no sufficient and well described studies in human but the drug usage in pregnant women distribute potential risk for fetus.

Tacromus 1mg capsule store at 25°C Do not keep the drug away from children accessible. Keep the container at cool and dry place and protect from light Dispense the capsule only in original container Keep away from spouse or other family members avoid accidently change of medicine.

If dose is missed then as soon as possible take the dose you remember before next dose otherwise skip the missed, if next dose time reached. Do not take extra dose at a time. Take advice of the doctor about missed dose.

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.