Tafero EM

Tafero EM is a fixed dose combination drug, which contains two excellent components like tenofovir Alafenamide fumarate and Emtricitabine Tafero EM is a prescription medicine, used by the patients only under the knowledge of medical practitioner

TAF and Emtricitabine

Tafero EM

25mg & 200mg


Tenofovir Alafenamide Fumarate & Emtricitabine

TAF and Emtricitabine are nucleotide reverse transcriptase inhibitor that involved in suppression of growth of HIV virus associated with AIDS

Tafero EM Indication

Tafero EM , a combination tablet contains tenofovir Alafenamide fumarate and Emtricitabine is mainly indicated for the treatment of HIV-1 infection in adult’s patients.

Tafero EM Pharmacology

TAF (Tenofovir Alafenamide Fumarate)

TAF is a novel ester prodrug of anti-retroviral tenofovir, and it is a nucleotide reverse transcriptase inhibitor After an oral administration, TAF is transformed into tenofovir Tenofovir (acyclic nucleoside phosphonate analog of adenosine 5 monophosphate)

Tenofovir depletes DNA binding, there is a lack of 3 OH molecules (water molecules are responsible for phosphodiester bond linkage) By opposing the regular nucleotide for insertion into proviral DNA and blockade of formation of 5 to 3 phosphodiester linkage which is needed for DNA elongation Tenofovir leads to chain termination and block proviral DNA transcription


Emtricitabine is one of the components of Tafero EM it exhibits its anti-retroviral activity by inhibiting reverse transcriptase, the enzyme which is responsible for transcript HIV RNA into new viral DNA. Emtricitabine is phosphorylated to Emtricitabine 5 phosphate with the help of cellular enzymes

Emtricitabine 5 phosphates is HIV-1 reverse transcriptase inhibitor Emtricitabine 5 phosphates fight with deoxycytidine 5 triphosphate (natural substrate) and inserted into viral DNA causes chain termination


Tafero EM the absorption of tenofovir is occur fastly and its Tmax is observed at 1 hour after administration; whereas Emtricitabine is absorbed rapidly and its mean bioavailability is 93%

The human plasma protein bound of Emtricitabine is very low less than 4% Tenofovir is highly bound to human plasma protein with the range of 80%

TAF, is hydrolyzed into tenofovir within the cells, it is the major metabolite again phosphorylated into tenofovir diphosphate active metabolite Emtricitabine is metabolized minimally and it is found in urine as unchanged form

The route of elimination mostly through urine The terminal half life of Emtricitabine is 10 hours The terminal half life period of tenofovir is 0.51 hour


tafero em
Brand Tafero EM
Ingredients Tenofovir Alafenamide Fumarate and Emtricitabine
Strength 25mg & 200mg
Manufactured Hetero

Tafero EM Dosage and administration

The usual dose of Tafero EM in the condition of HIV-1 infection in adults is, one tablet should be taken once daily with or without food. Uninfected adults should take one tablet orally as a single dose in Pre-exposure Prophylaxis.


Diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, abnormal drms


Increased fasting cholesterol, decreased phosphorus, increased fasting triglycerides, altered serum glucose, weight loss, hyperglycemia, increased alkaline phosphatase, lactic acidosis severe hepatomegaly


Increased AST and ALT, hepatic steatosis, lactic acidosis, increased bilirubin, severe acute exacerbation of hepatitis B


Decreased neutrophils and hemoglobulin


Pharyngitis, sinusitis, upper respiratory tract infection, Nasopharyngitis, increased cough, pneumonia, rhinitis


Increased serum amylase, abdominal pain, pancreatitis, increased serum lipase


Depression, insomnia, anxiety

Nerve system

Headache, somnolence, peripheral neuropathy


Fatigue, syphilis, pain, fever, asthenia, high vitamin D levels


Rashes, skin discoloration, lipodystrophy, angioedema, sweating


Protein in urea, blood in urine ,urethritis, urinary tract infection, genital ulceration, anogenital warts Polyuria, glycosuria


Immune reconstitution/reactivation syndrome, autoimmune disorders


Allergic reaction


High serum parathyroid hormones


Tafero EM should be used cautiously, during the therapy some of adverse effects occur; Immune reconstitution syndrome Lactic acidosis Hepatomegaly with steatosis Renal toxicity Acute or severe exacerbations of HBV occurs during discontinuation of anti-retroviral therapy Renal impairment

Tafero EM Drug interaction

  • Acyclovir-valaciclovir: increase the serum concentration of tenofovir
  • Adefovir: decrease the therapeutic effect of tenofovir
  • Amino glycosides: increase the serum concentration of tenofovir
  • Carbamazepine: decrease the serum concentration of tenofovir
  • Cidofovir: increase the serum concentration of tenofovir
  • Cobicistat: may increase the toxic effects of tenofovir
  • Diclofenac: may enhance the nephrotoxicity effect of tenofovir
  • Fosphenytoin/phenytoin: decrease the serum concentration of tenofovir
  • Lamivudine: increase toxic effects of Emtricitabine
  • NSAIDS: increase the nephrotoxicity effect of tenofovir
  • Orlistat: decrease the serum concentration of anti-retroviral drugs Oxcarbazepine, Phenobarbital, primidone, rifabutin, rifampin, rifapentine, st.Johns wort, tipranavir these are the drugs which involved in depletion of serum concentration of tenofovir

Tafero EM Contraindication

Tafero EM should not be used in persons with unknown or positive 1 status.

Tafero EM not used as monotherapy, it is used with other retroviral medicine. Hypersensitivity in lactation

Pregnancy category: B Tafero EM should be used cautiously, it is recommended for limited number for pregnancy In case of any deformity, Tafero EM should not suggested for pregnancy condition or women who become pregnant

Breast feeding is not recommended

Tafero EM tablet container should be stored below 30°C (86°F) Protect the drug container away from moisture, heat and light

If patient fail to take the dose of Tafero EM tablet, must consult with medical practitioner To avoid overdose toxicity problems, skipped the missed dose and follow the regular dosing schedule Do not take double dose


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