Tafero

Tafero tablets are required to prevent for HIV-1 infections, now it is also indicated in the condition like hepatitis B viral infection Tenofovir Alafenamide is an active most predominant component which is present in Tafero tablet. An ideal activity of Tafero tablet is; Anti-HIV or Anti-retroviral activity Anti-hepaciviral activity Tafero is not a curable medicine; it may prevent transmission of virus to others and reduce the exposure

Tenofovir Alafenamide

Tafero

25mg

Hetero




Tafero tablets are used for

Tafero tablet are majorly indicated in the conditions like; Now-a-days Tafero is used to treat chronic hepatitis B viral infection in adolescent patients with compensated (child Pugh A) liver disease.

Tafero strength availability

Tafero is available in the form of tablet containing 25mg of tenofovir Alafenamide as an active ingredient



Tafero tablet consist as tenofovir Alafenamide, which is prodrug converted in in-vivo as an active form. Tenofovir Alafenamide is lipophilic in nature has cell penetrable effect, which permeates into liver cells by passive diffusion method. After that, TAF is altered into tenofovir by undergoing hydrolysis with the help of carboxylesterase-1 which is present in liver cells.

Tenofovir is phosphorylated into tenofovir diphosphate intracellularly using cellular kinase enzyme. The pharmacologically active metabolite tenofovir diphosphate is expels anti-hepaciviral activity by obstructing hepatitis B viral multiplication through infusion of this metabolite by reverse transcriptase enzyme into viral DNA

The absorption of Tafero tablet is occurs rapidly, the peak plasma time occurs in 0.48 hours The effect of Tafero with food (high fat meal) is occurs as 1.65 (0.51, 1.81) compared to fasted state.

The human plasma protein bound to Tafero tablet is occurs nearly at 80% The blood to plasma ration of Tafero tablet is attains at 1.0

Tafero tablet is metabolized into active form by carboxylesterase-1, cathepsin A (PBMC’s) The major route of elimination of tenofovir Alafenamide metabolites occurs through urine <1%; feces 31.7% The terminal half life period of Tafero tablet is reaches in 0.51 hours



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Tafero
Brand Tafero
Ingredients Tenofovir Alafenamide
Strength 25mg
Manufactured Hetero
Rating

Before starting the therapy

Tafero has some serious life-threatening conditions, to control this problems patient should be counsel about the exposure of risk associated with Tafero therapy

Some precautions

Before initiating the therapy with Tafero tablets, patient must be investigating by measuring the count of HBV antigen & HBV core anti-body Examine the patients for HIV-1 infection, if test is positive Tafero should not be used alone, combined with other anti-retroviral medicines The recommended dosage of Tafero tablet is 25mg of tablet should be taken as a single dose with food Tafero is used as single dose therapy In renal and hepatic impairment patients, dosage adjustment is not suggested In decompensated cirrhosis condition, Tafero is not recommended

Over dosage

If over dosage occurred in the patients who are receiving Tafero , should be observed for affirmation of toxicity and monitor the symptoms occur. The other route to control the over dose of tenofovir is hemodialysis, used to eradicate the tenofovir content from the body by separating at the range of 54%

Serious adverse effects

Risk of severe acute worsening of hepatitis B viral infection Aggression of renal impairment Lactic acidosis or hepatomegaly with steatosis

Common side effects

Headache, Fatigue, Abdominal pain, Nausea, Back pain, Cough, Glycosuria, Pancreatitis, Amylase and lipase elevation

Tafero tablet should be used carefully in the conditions like

Kidney related problems, HIV infected patients (used in combination with anti-retroviral drugs), Hepatic problems, Bone problems, Pancreatitis In severe acute aggravation of HBV infection, to avoid this problem patients should be monitored frequently with their clinical rating and symptoms before going to start the treatment

Exposure of development of HIV resistance in patients who are having HIV-1/HBV co infection

To prevent this condition patients should be investigate by measuring antibody counting New outbreak or aggravation of renal problems, to control these problems avoid concomitant of drugs depleting the renal functions with Tafero tablets or monitored the laboratory levels periodically Lactic acidosis or hepatomegaly with steatosis, treatment should be discontinued

Limitations involved in Tafero tablet

The major drawback of Tafero tablets are followed as; After discontinuation of treatment, serious conditions like hepatomegaly with steatosis or lactic acidosis occurs Severe aggravation of acute hepatitis B infection

Tafero interacted with some drugs like

  • Tenofovir Alafenamide is a P-gp& BCRP transporter substrate, while concurrent usage of Tafero with P-gp or BCRP strong inhibitors causes alteration in absorption of tenofovir Alafenamide
  • P-gp or BCRP inducers decreases the effect of concentration of tenofovir Alafenamide which leads to reduce the healing effect of tenofovir Alafenamide
  • Moderate inhibitor of P-gp or BCRP with Tafero tablet causes increasing the concentration of tenofovir Alafenamide
  • Tafero combined with drugs which reduce the renal functions causes increasing the concentration of tenofovir Alafenamide. This is because tenofovir is highly eliminated through kidney
  • Tafero with anti-convulsants like phenytoin, Phenobarbital, or carbamazepine causes decreasing the tenofovir Alafenamide concentration
  • Tenofovir Alafenamide interacts with anti mycobacterials agents causes decreasing the effect of concentration of TAF
  • Tafero with st Johns wort causes decreasing the therapeutic effect of tenofovir Alafenamide


Tafero contraindicated


No contraindication occurs in Tafero usage.

Some hypersensitivity reactions may causes due to contraindicated to component of Tafero tablet



Tafero uses in specific population

Tafero is used in safe manner In some patients, tenofovir Alafenamide metabolite under gone placental transformation in such conditions Tafero tablet should not be recommended Tafero is used only under the guidance of medical practitioner during pregnancy

In HIV infected condition, breast feeding is not suggested to prevent the adverse effects, consult with physician

The safety and efficacy of Tafero tablets in pediatric patients with the age less than 18 years has not been established

Tafero tablet container should be kept at room temperature below 30°C Protect the container away from moisture, heat & light

If patient missed to have the dose of Tafero tablet, should consult with physician and take the dose as soon as possible. Or the missed dose should be skipped and follow the regular dosing schedule





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