Tamtero 10mg

Tamtero 10mg is a type of hormone (endocrine) therapy used to treat breast cancer in both pre-menopausal women (women who have not yet gone through the menopause) and post-menopausal women.
It can also be taken by men who have breast cancer.

Tamoxifen

Tamtero

10mg

Hetero




Indication

Tamtero 10mg is indicated for the treatment of early breast cancer in women whose been already treated with surgery, radiation, and chemotherapy.
Tamtero 10mg may also be used to treat local recurrence or locally advanced breast cancer (known as regional recurrence). It may also be used if you’ve been diagnosed with secondary breast cancer
Tamtero 10mg will prevent the risk of developing a more severe type of breast cancer in women who had breast cancer that will not spread outer part of the milk duct where it form (ductal carcinoma).

Mechanism of action

Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow.
Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor.
This slows or stops the growth of the tumour by preventing the cancer cells from getting the hormones they need to grow.



Pharmacokinetics

The time to high plasma concentration is 40mg/ml and Tmax is 5 hours after dosing.

Not available

In hepatic Tamtero 10mg is metabolized.

Route of excretion is 30% via fecal and 65% was excreted from the body
Half-life is 5 to 7 days


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drug
Brand Tamtero
Ingredients Tamoxifen
Strength 10mg
Manufactured Hetero
Rating

Regular adult dose is 20 to 40mg for 5 years daily administer orally for breast cancer doses is > 20mg given by dividing dose (morning and evening) 20mg 5 years daily given orally for DCIS followed by surgery and radiation on breast For 5 years administer 20mg daily taken orally to decrease the action of breast cancer in women at increased risk for breast cancer 20mg OD orally or 10mg twice daily orally given for adult dose for adjuvant breast cancer and Duration: 5 years Pediatric dose for girls 2 to 10 years is 20mg once daily via oral route; duration up to 12 months administrated for McCune- Albright syndrome
20mg once daily via oral route; duration up to 12 months given for Precocious Puberty
OVERDOSAGE: Acute overdose is not considered in humans, in animals If administer heavy dose then leads in respiratory difficulties and convulsions and in human unsteady gait, acute neurotoxicity manifested by tremor, hyperreflexia, and vertigo was reported. There is no specific treatment for overdose. Hence provide the patients by symptomatic supportive measures

Common Side Effect:
• Increased Tumor Or Bone Pain
• Hot Flashes
• Nausea
• Fatigue
• Mood Swings
• Depression
• Headache
• Hair Thinning
• Constipation
• Dry Skin
• Loss of Libido. Serious side effects may be as follows, immediately inform the doctor:
• Abscess on the, throat, face, lips, eyes, tongue, ankles or lower legs
• Thirst
• muscle weakness
• restlessness
• loss of appetite
• Vision difficulty
• Fever
• Blisters.

Precaution

Consult with the doctor or pharmacist as if you have allergic condition against Tamtero 10mg or any of the compound in Tamoxifen tablets.
Consult with the doctor that you have or have ever had renal, hepatic, or cardiac problem
Consult with the doctor that are you pregnant or plan to become pregnant. Do not have plan for children while on treatment with Tamtero 10mg. You must use a specific method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Tamtero 10mg the drug will harm the fetus.
Avoid breast feeding while on treatment with Tamtero 10mg
Use drug with caution due to early breast cancer signs hence during treatment with tamoxifen aware about development of breast cancer.
Some important precautions should take care;
Some breast cancer patients may have reported from hypercalcemia by starting few weeks treatment, if the condition occur and became severe then tamoxifen should discontinue.
An incidence may increase with uterine malignancies and endometrial carcinoma is resulted with tamoxifen treatment.
Due to estrogen properties of tamoxifen, an increased incidence of endometrial changes occurs involves like hyperplasia and polyps has been resulted. Hence the drug causes menstrual irregularity or amenorrhea.

DRUG INTERACTION

  • Interaction with selective serotonin reuptake inhibitors (SSRIs) antidepressant, paroxetine will decrease the effectiveness of tamoxifen

  • While interaction of Tamtero 10mg with coumarin type anticoagulants combination will leads to increase in anticoagulant effects may occur.
  • Concomitant use of Bromocriptine with Tamtero 10mg will increase the serum level of Tamtero 10mg and N-desmethyl tamoxifen.

Missed Dose

If the dose is missed, then take the dose immediately before next dose duration
Next dose time arrived then left off the missed dose and follows regular schedule.
Avoid taking extra dose at same time.
Please consult the doctor for further details



Category D: If Tamtero 10mg administrated to pregnant women will cause harm to fetal. Women are advised to stop the drug within 2 months and not become pregnant while taking Tamtero 10mg. And If sexually active then should use non-hormonal contraceptive measures.

The drug stored at 15°C-30°C
Keep the drug in dry cool place
Dispense the only in original container

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