Sirotem 25mg is a Kinase Inhibitor. The mechanism of action of Sirotem is as a Protein Kinase Inhibitor.
Sirotem 25mg contains intravenous drug for the therapy of Kidney cancer developed by Wyeth Pharmaceuticals and approved by the FDA in late May 2007
Sirotem 25mg is a prescription drugs which is used under the supervision of medical oncologist.
1 injection in a vial
Sirotem 25mg is indicated for the treatment of advanced renal cell carcinomas.
Mechanism of action
Temsirolimus belongs to ester associated of rapamycin. Temsirolimus connect to and prohibits the mammalian aim of rapamycin (mTOR), will cause in reduced expression of mRNAs required for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threoninekinase which plays a role in the PI3K/AKT pathway which is upregulated in some tumors.
Time to peak plasma time is 0.5-2 hr after infusion (sirolimus)
volume of distribution is 172 L
Metabolized in liver; through CYP3A4 to active metabolite sirolimus and several other metabolites
excretion through feces 78% and urine <5%
Half-Life: 17hr (Temsirolimus); 55hr (sirolimus)
Advanced Renal cell carcinoma :
Pre-treat with antihistamines (e.g. diphenhydramine 25-50 mg IV 30 minutes preinfusion
The recommended dose is 25mg IV infusion qweek until disease progression or unacceptable
More common side effects :
Nausea, Swelling , Poor appetite , Hyperglycaemia, High in blood cholesterol levels, Hypophosphatemia, Weakness, Low blood counts , Rash, Mouth sores , Increased liver enzymes, Increased blood creatine levels.
Less common side effects for patients receiving Temsirolimus :
Weight loss, Low white blood cell count, Generalized aches and pains, Chest pain , Headache , nail disorder/thinning , Insomnia , Nose bleed , Sore throat, Dry skin, Shortness of breath , Pain, Swelling in legs and feet , Diarrhea , Cough , Fever , Low potassium , Abdominal pain, Infection, Constipation, Taste disturbance , Back pain , Itching, Vomiting .
Infections may report from immunosuppression
Bowel perforation may result; monitor fever, abdominal pain, bloody stools, and/or acute abdomen immediately
Renal failure, sometimes fatal, has resulted; monitor renal function at baseline and while on therapy
Due to atypical wound healing, use caution in perioperative period
Elderly patients may be more likely to experience certain adverse reactions, containing diarrhea, edema and pneumonia